Incidence of Colorectal Cancer in Urban
Population Exposed to Cadmium

Rogala, D; Marchwińska-Wyrwał, Ewa; Spychała, Anna; Hajok, Ilona

doi:10.15244/pjoes/92707

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…Also, the pediatric and AYA cancers with positive associations between PM 2.5 and mortality in this study had prior evidence, to varying degrees, of an association with PM 2.5 and incidence of those same cancers. PM 2.5 is associated with incident pediatric leukemia, lymphomas, brain astrocytomas, and adult breast and colorectal cancers (60)(61)(62)(63)(64)(65). Further research is needed to confirm our findings and elucidate the underlying mechanisms of these associations.…”

Section: Discussionmentioning

confidence: 57%

Fine Particulate Matter Air Pollution and Mortality among Pediatric, Adolescent, and Young Adult Cancer Patients

Hanson

Ramsay

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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◥Background: Air pollution is a carcinogen and causes pulmonary and cardiac complications. We examined the association of fine particulate matter pollution (PM 2.5 ) and mortality from cancer and all causes among pediatric, adolescent, and young adult (AYA) patients with cancer in Utah, a state with considerable variation in PM 2.5 .Methods: We followed 2,444 pediatric (diagnosed ages 0-14) and 13,459 AYA (diagnosed ages 15-39) patients diagnosed in 1986-2015 from diagnosis to 5 and 10 years postdiagnosis, death, or emigration. We measured average monthly PM 2.5 by ZIP code during follow-up. Separate pediatric and AYA multivariable Cox models estimated the association of PM 2.5 and mortality. Among AYAs, we examined effect modification of PM 2.5 and mortality by stage while controlling for cancer type.Results: Increases in PM 2.5 per 5 mg/m 3 were associated with cancer mortality in pediatric lymphomas and central nervous system (CNS) tumors at both time points, and all cause mortality in lymphoid leukemias [HR 5-year ¼ 1.32 (1.02-1.71)]. Among AYAs, PM 2.5 per 5 mg/m 3 was associated with cancer mortality in CNS tumors and carcinomas at both time points, and all cause mortality for all AYA cancer types [HR 5-year ¼ 1.06 (1.01-1.13)]. PM 2.5 ≥12 mg/m 3 was associated with cancer mortality among breast [HR 5-year ¼ 1.50 (1.29-1.74); HR 10-year ¼ 1.30 (1.13-1.50)] and colorectal cancers [HR 5-year ¼ 1.74 (1.29-2.35); HR 10-year ¼ 1.67 (1.20-2.31)] at both time points. Effect modification by stage was significant, with local tumors at highest risk.Conclusions: PM 2.5 was associated with mortality in pediatric and AYA patients with specific cancers.Impact: Limiting PM 2.5 exposure may be important for young cancer patients with certain cancers.See all articles in this CEBP Focus section, "Environmental Carcinogenesis: Pathways to Prevention."

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Section: Discussionmentioning

confidence: 57%

Fine Particulate Matter Air Pollution and Mortality among Pediatric, Adolescent, and Young Adult Cancer Patients

Hanson

Ramsay

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…We assessed occupational agents which were contained in MatEmEsp, and for which there were sufficient participants exposed to heat and the other agents including any metal (lead, cadmium, chromium, nickel, iron), solvent (aliphatic and alicyclic hydrocarbons, aromatic hydrocarbons, chlorinated hydrocarbons, and other organic solvents), pesticide (2,4-D, atrazine, captan, chlorpyrifos, dicuat, diuron, endosulfan, methomyl, pyrethrin, tiram), polycyclic aromatic hydrocarbons (PAHs), and detergents. Some studies have previously linked some agents with CRC risk (42)(43)(44)(45), although the evidence is uncertain.…”

Section: Discussionmentioning

confidence: 99%