Incidence, risk factors, and prognosis of meningiomas with distant metastases at presentation

Abstract

Background Distant metastases (DM) at presentation in meningiomas is a very rare event, and the incidence and factors predicting this are uncertain. This population-based study also aimed to investigate the prognostic implication of DM at presentation and clinical parameters to prognosticate the overall survival (OS) of meningiomas presenting with DM (M1). Methods We accessed the Surveillance, Epidemiology, and End Results program to search for patients who were diagnosed with meningioma between 2004-2016. The log-rank test was used to compare Kaplan-Meier survival curves and multivariate Cox regression model was utilized to evaluate the prognostic parameters of meningiomas with DM at presentation. Results The incidence of DM at presentation among all meningiomas was 0.18%. Clinical variables associated with this event were male gender, large tumor size, and WHO grade III. The presence of DM at diagnosis conferred a shorter survival in comparison to those without DM (HR = 2.015; 95% CI = 1.600-2.536). Older patient age, male gender, malignant histology, and the lesser extent of resection were independent prognostic factors that could negatively impact OS of M1 meningiomas. Radiotherapy and chemotherapy were not associated with an improved outcome for these patients. Conclusion Our study highlighted the clinical and prognostic factors of M1 meningiomas. These data suggest that a greater extent of resection is associated with increased OS across a nationwide analysis and emphasize the need to establish the standards of care in these patients.

Metastasis of Malignant Intracranial Meningioma to the Lung: Report of a Case and Review of the Relevant Literature

“…Higher grade, more frequent metastasis has been found in the literature review. The incidence of extracranial metastatic meningioma grade I ranged from 3.6-29.3%, grade II ranged from 6.8-57.1%, and grade III ranged from 39.3-63.9% according to prior studies [1,2]. The present case was initially diagnosed with meningothelial meningioma, WHO grade I with malignant transformation to atypical meningioma.…”

“…Extracranial metastasis of meningioma is an uncommon presentation. The incidence of meningioma metastasis was reported to be 0.18-0.67% [1,2]. Common metastatic sites include the lungs and intra-abdominal organs.…”

“…xtracranial metastasis of meningioma has a low incidence rate [1,2]. A few cases have been reported in the literature.…”

“…Because distant metastasis of this tumor is rare, there is no standard treatment for metastatic meningioma; chemotherapy is the only alternative treatment. The prognosis for patients with metastasis is poor; a previous study reported that patients with metastatic meningioma were significantly associated with a poor prognosis compared to patients without metastasis [2]. Moreover, the median survival time for patients with metastasis was 35 months (Interquartile Range [IQR] 8-69), while patients without metastasis had a median survival time of 50 months (IQR, 25-84) [2].…”

Epidemiology and survival of non-malignant and malignant meningiomas in middle-aged females, 2004-2018

“…Although most meningiomas are benign, approximately 20% of patients have aggressive meningiomas with poor a prognosis ( 1 ). Many studies have confirmed that the incidence of meningioma is disparate by sex, and the female-to-male ratio of IR is over than three in the 35–54-year group ( 1 , 2 , 13 , 14 ). However, the underlying mechanism remains unclear.…”