Incidence Trend of The Leukemia Reported Cases in The Kingdom of Saudi Arabia, Observational Descriptive Statistic From Saudi Cancer Registry

sCD14 is an acute phase reactant; few studies reported its prognostic value in B-CLL patients. This gave us the impetus to conduct this study. This study enrolled 40 newly diagnosed B-CLL Egyptian patients, presented to the Hematology Department of the Medical Research Institute in Alexandria University. The ZAP-70 was determined by flow cytometry whereas serum sCD14 concentration by human sCD14 sandwich ELISA method. The mean serum level of sCD14 was significantly higher among patients with positive ZAP-70, Binet stage C, Rai stage III-IV and high risk CLL prognostic index. It showed a significant positive correlation to the percentage of ZAP-70 expression and significant negative correlation to the hemoglobin concentration. Serum sCD14 concentration could be used to assess B-CLL patients initially as an additional prognostic marker, especially in low resources areas where flow cytometry is not available.

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Evaluation of Prognostic Impact of Soluble CD14 in B-Chronic Lymphocytic Leukemia

Al-Kahiry

Sharshira

Ghanem

et al. 2016

Indian J Hematol Blood Transfus

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Bcl-2 Family Overexpression and Chemoresistance in Acute Myeloid Leukemia

Silva

2018

Serbian Journal of Experimental and Clinical Research

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The family of Bcl-2 proteins is one of the most responsible for apoptosis pathway, that is a critical process to the maintenance of tissue homeostasis. Bcl-2 is an essential apoptotic regulator belonging to a family of functionally and structurally related proteins known as the Bcl-2 family. Some members of this family act as anti-apoptotic regulators, whereas others act in pro-apoptotic function. The relationship between the pro and anti-apoptotic proteins can regulate whether cells begin the apoptosis or remain its life cycle. Increasing of Bcl-2 expression has been found in some hematologic diseases, such as Acute Myeloid Leukemia (AML) and their effects on responsiveness to anticancer therapy have been recently described. Thus, this review aims to discuss apoptosis and the role of the Bcl-2 family of proteins in chemoresistance when overexpressed in patients committed with Acute Myeloid Leukemia submitted to chemotherapy treatment.

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Incidence Trend of The Leukemia Reported Cases in The Kingdom of Saudi Arabia, Observational Descriptive Statistic From Saudi Cancer Registry

Cited by 2 publications

References 8 publications

Evaluation of Prognostic Impact of Soluble CD14 in B-Chronic Lymphocytic Leukemia

Evaluation of Prognostic Impact of Soluble CD14 in B-Chronic Lymphocytic Leukemia

Bcl-2 Family Overexpression and Chemoresistance in Acute Myeloid Leukemia

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