Incidental diagnosis of a PSA-negative prostate cancer by 18FDG PET/CT in a patient with hypopharyngeal cancer

Bucerius, Jan; Ahmadzadehfar, Hojjat; Hortling, N; Ay, Joe; Palmedo, Holger; Hj, Biersack

doi:10.1038/sj.pcan.4500959

Cited by 11 publications

(8 citation statements)

References 28 publications

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“…No increase in PSA has been detected in a substantial number of prostate cancer patients. Thus, it appears that new biomarkers are needed for the diagnosis and prognosis of patients with prostate cancer …”

Section: Introductionmentioning

confidence: 99%

Elevated levels of mitochondrion‐associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer

Jiang

Huang

et al. 2014

Cancer

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BACKGROUND Autophagy has recently been found to play important roles in tumorigenesis and LRPPRC has been identified as an inhibitor that suppresses autophagy and mitophagy and maintains mitochondrial activity. We hypothesized that LRPPRC levels can be used as a biomarker for diagnosis and prognosis of prostate cancer. METHODS We performed immunochemistry analysis to evaluate the levels of LRPPRC in 112 samples collected from patients with prostate adenocarcinomas (PCa) and 38 samples from patients with benign prostate hyperplasia (BPH) enrolled in hospitals in Guangzhou city of China that have been followed up for 10 years. RESULTS We found that there were significant higher levels of LRPPRC in PCa than in BPH. More than three quarters of PCa patients showed high levels of LRPPRC while only 10% of BPH patients had similar levels of LRPPRC. The levels of LRPPRC protein were positively correlated with tumor grade, metastasis and serum PSA, but negatively correlated with hormone therapy sensitivity after 2 years of surgery and overall survival. The association of high levels of LRPPRC with late stage of PCa or hormone therapy insensitivity was confirmed in tissue samples collected from prostate-specific PTEN−/− mice or hormone-dependent and independent prostate cancer cell lines. CONCLUSION The levels of LRPPRC may be used as an independent biomarker for PCa patients at late-stage with poor prognosis.

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Section: Introductionmentioning

confidence: 99%

Elevated levels of mitochondrion‐associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer

Jiang

Huang

et al. 2014

Cancer

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“…This biological heterogeneity is reflected in the current perceived mixed experience with FDG-PET in prostate cancer. Animal and preliminary clinical studies have demonstrated that FDG-PET may be useful in the evaluation of patients with high Gleason score primary tumors and serum prostate specific antigen (PSA) levels, in the assessment of the extent of advanced androgen-independent disease, in the detection of metabolically active osseous and soft tissue metastases, and in the assessment of response after androgen ablation and treatment with the novel chemotherapies [7–22]. Studies have shown that FDG accumulation in both the primary tumor and the metastatic sites decreases in as early as 1–5 months after androgen ablation, which is concordant with the decline in serum PSA level and lesion size on CT [9, 23].…”

Section: Introductionmentioning

confidence: 99%

[F-18]-fluorodeoxyglucose PET-CT of the normal prostate gland

et al. 2008

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Objective-We determined the glucose metabolism and computed tomographic (CT) density of the normal prostate gland in relation to age and prostate size on [F-18] fluorodeoxyglucose positron emission tomography (PET)-CT.Methods-We determined the CT density (Hounsfield Units, HU) and glucose metabolism (standardized uptake value, SUV) of the normal prostate in 145 men (age range 22-97 years) on PET-CT scans which were performed for indications unrelated to prostate pathology. Correlations among SUV, HU, prostate size, and age were calculated using Pearson's correlation coefficients, scatter plots, and linear regression trend lines. The SUV and HU values were also compared among different primary cancer types using the Kruskal-Wallis test.Results-The population average and range of the normal prostate size were 4.3 ± 0.5 cm (mean ± SD) and 2.9-5.5 cm, respectively. The population average of mean and maximum CT densities was 36.0 ± 5.1 HU (range 23-57) and 91.7 ± 20.1 HU (range 62-211), respectively. The population average of mean and maximum SUV was 1.3 ± 0.4 (range 0.1-2.7) and 1.6 ± 0.4 (range 1.1-3.7), respectively. Mean SUV tended to decrease as the prostate size increased (r = −0.16, P = 0.058). Higher mean HU was correlated with higher mean SUV (r = 0.18, P = 0.033). The strongest association was observed between age and prostate size. The prostate gets larger as age increases (r = 0.32, P < 0.001). Prostate mean SUV, max SUV, mean HU, and max HU were not significantly different among different types of primary cancers.Conclusions-Although the normal prostate size increases with age, it does not significantly affect the gland's metabolism and CT density, and therefore age-correction of these parameters may be unnecessary.

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“…FDG-PET has limited use in diagnosis and staging of clinically organ-confined disease,11 apart from case reports 12 13. FDG-PET might be useful for detecting locally recurrent and/or metastatic disease 14.…”

Section: Discussionmentioning

confidence: 99%

Sciatic neuropathy as first sign of metastasising prostate cancer

Hansen¹,

Rasti

Smith

et al. 2010

Case Reports

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SummaryPeripheral neuropathies are among the most common neurological diseases and have numerous causes, including diabetes, alcohol, hereditary, toxic, metabolic, infectious, inflammatory, ischaemic and paraneoplastic. Often, however, no definitive cause is identified and the condition is termed idiopathic neuropathy. Here we describe a patient who was initially diagnosed with idiopathic sciatic neuropathy but who was eventually diagnosed with prostate cancer. This is an uncommon manifestation of prostate cancer, and the diagnostic was difficult because prostatespecific antigen (PSA) was normal and the positron emission tomography scan negative. Changes in PSA should always raise the suspicion of prostate cancer, just as idiopathic progressive neuropathy should always raise the suspicion of an underlying malignancy, even when standard diagnostics fail to explain the patient's symptoms. BACKGROUND

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Incidental diagnosis of a PSA-negative prostate cancer by 18FDG PET/CT in a patient with hypopharyngeal cancer

Cited by 11 publications

References 28 publications

Elevated levels of mitochondrion‐associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer

Elevated levels of mitochondrion‐associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer

[F-18]-fluorodeoxyglucose PET-CT of the normal prostate gland

Sciatic neuropathy as first sign of metastasising prostate cancer

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