Incidental Finding of Hibernoma in Prostate-Specific Membrane Antigen PET/CT

Abstract

We reported the case of a 76-year-old man followed up since 2008 for a prostatic adenocarcinoma with pelvic and retroperitoneal nodes. He was initially treated by hormonotherapy with a good biological response. Twelve years after, he demonstrated an increased PSA level up to 10.2 ng/mL. He underwent a 68Ga-PSMA PET/CT, which shown an intense uptake by a left iliac extern mass, suspected of recurrence. The histology concluded in a hibernoma.

Discriminating Inflammatory Radiation-Related Changes From Early Recurrence in Patients With Glioblastomas

“…We previously reported a case of hibernoma and a case of interstitial pneumopathy due to polyangiitis granulomata, both of which demonstrated a very intense uptake, suggesting that even nonneoplastic vasculature and inflammatory vasculature can show strong 68 Ga-PSMA-11 uptake. 51,52 For this study, we determined that it was judicious to perform 68 Ga-PSMA-11 PET/CT examinations 3 months after the end of the radiotherapy and 6 months after treatment with bevacizumab FIGURE 3. Patient P09 display concordant images, suggestive of postradiation-related remodeling.…”

Retroperitoneal hibernoma resected via laparoscopic surgery

“…Using the PubMed database, we searched for "hibernoma retroperitoneal" and found nine cases of this tumor in the abdominal cavity. [2][3][4][5][6][7][8][9][10] To our knowledge, this is the second case report of laparoscopic surgery for hibernoma removal. The patient's short-term results demonstrated that laparoscopic surgery is a viable option for hibernomas (Table 1).…”

“…Using the PubMed database, we searched for “hibernoma retroperitoneal” and found nine cases of this tumor in the abdominal cavity 2–10 . To our knowledge, this is the second case report of laparoscopic surgery for hibernoma removal.…”

The Usefulness of Short-Interval Sequential FDG PET/CT Studies in Defining the Benignity of Hypermetabolic Lipomatous Tumor

“…Scarce reports have demonstrated increased FDG uptake within hibernoma due to the metabolic activity in brown fat cells 5–12 . Incidental 68 Ga-PSMA uptake was also reported 13 . Differentiation of benign and malignant entities based on a single SUV measurement at baseline PET/CT was not possible.…”