Inclusion of lycorine with natural cyclodextrins (α-, β- and γ-CD): Experimental and in vitro evaluation

Liu, Dandan; Guo, Yafei; Zhang, Jianqiang; Yang, Zhikuan; Li, Xiang; Yang, Bo; Yang, Rui

doi:10.1016/j.molstruc.2016.11.018

Cited by 19 publications

(8 citation statements)

References 30 publications

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“…2 a). These results indicated that β-CD had a typical cage structure, which was consistent with the findings of another study ( Liu and Guo, 2017 ). Some new diffraction peaks were detected for luteolin-β-CD, which indicated that the molecular structure of β-CD was transitioned between the cage and layer ( Guo et al, 2011 ).…”

Section: Resultssupporting

confidence: 92%

β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin

Yang,

Zhao,

Huang

et al. 2024

International Journal of Pharmaceutics: X

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Section: Resultssupporting

confidence: 92%

β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin

Yang,

Zhao,

Huang

et al. 2024

International Journal of Pharmaceutics: X

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“…Previous literature data showed that β-cyclodextrin inclusion complex improved in vivo anti-cancer activity of curcumin (Zhang et al, 2016). Similarly, better in vitro cytotoxic activities were observed in cases of encapsulated norathyriol and lycorine (Han et al, 2014, Liu et al, 2017). Also, it should be noted that US Food and Drug Administration include β-cyclodextrin into GRAS (generally recognized as safe) carriers and protectants (USFDA, 2001).…”

Section: Introductionmentioning

confidence: 81%

Effect of β-cyclodextrin encapsulation on cytotoxic activity of acetylshikonin against HCT-116 and MDA-MB-231 cancer cell lines

Vukić

Vuković

Popović

et al. 2020

Saudi Pharmaceutical Journal

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Acetylshikonin (AcSh), as a red colored pigment found in roots of the plants from family Boraginaceae, showed excellent cytotoxic activity. Due to its hydrophobic nature, and thus poor bioavailability, the aim of this study was to prepare acetylshikonin/β-cyclodextrin (AcSh/β-CD) inclusion complex by using coprecipitation method, characterize obtained system by using UV/VIS, IR and 1H NMR spectroscopy, and determine cytotoxic activity. Phase solubility test indicated formation of AL-type binary system (substrate/ligand ratio was 1:1 M/M), with stability constant Ks of 306.01 M−1. Formation of noncovalent bonds between inner layer of the hole of β-CD and AcSh was observed using spectroscopic methods. Notable changes in chemical shifts of two protons (−0.020 ppm) from naphthoquinone moiety (C6-H and C7-H), as well as protons from hydroxyl groups (−0.013 and −0.009, respectively) attached to C5 and C8 carbons from naphthoquinone part indicate that the molecule of AcSh enters the β-CD cavity from the aromatic side. Cytotoxic activity against HCT-116 and MDA-MB-231 cell lines was measured by MTT test and clonogenic assay. Mechanisms of action of free AcSh and inclusion complex were assessed by flow cytometry. In comparison to free AcSh, AcSh/β-CD showed stronger short-term effect on HCT-116 cells and superior long-term effect on both cell lines. Inclusion complex induced more pronounced cell cycle arrest and autophagy inhibition, and induced increase in accumulation of intracellular ROS more effectively than free AcSh. In conclusion, AcSh/β-CD binary system showed better performances regarding cytotoxic activity against tested tumor cell lines.

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“…Adapted with permission. [143,144] Copyright 2016, Published by Elsevier B.V and Copyright 2013, Licensee IntechOpen. highly viscoelastic nature, which have potential applications in tissue engineering.…”

Section: Crosslinking By Host-guest Inclusion Complexesmentioning

confidence: 99%

“…Figure 8. a) Morphological and b) skeletal chemical structures of cyclodextrin α-, βand γ, having 6, 7 and 8 glucose repeating units respectively. Adapted with permission [143,144]. Copyright 2016, Published by Elsevier B.V and Copyright 2013, Licensee IntechOpen.…”

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confidence: 99%

Supramolecular Hydrogels: Design Strategies and Contemporary Biomedical Applications

Omar

Ponsford

Dreiss

et al. 2022

Chemistry An Asian Journal

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Self‐assembly of supramolecular hydrogels is driven by dynamic, non‐covalent interactions between molecules. Considerable research effort has been exerted to fabricate and optimise supramolecular hydrogels that display shear‐thinning, self‐healing, and reversibility, in order to develop materials for biomedical applications. This review provides a detailed overview of the chemistry behind the dynamic physicochemical interactions that sustain hydrogel formation (hydrogen bonding, hydrophobic interactions, ionic interactions, metal‐ligand coordination, and host‐guest interactions). Novel design strategies and methodologies to create supramolecular hydrogels are highlighted, which offer promise for a wide range of applications, specifically drug delivery, wound healing, tissue engineering and 3D bioprinting. To conclude, future prospects are briefly discussed, and consideration given to the steps required to ultimately bring these biomaterials into clinical settings.

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Inclusion of lycorine with natural cyclodextrins (α-, β- and γ-CD): Experimental and in vitro evaluation

Cited by 19 publications

References 30 publications

β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin

β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin

Effect of β-cyclodextrin encapsulation on cytotoxic activity of acetylshikonin against HCT-116 and MDA-MB-231 cancer cell lines

Supramolecular Hydrogels: Design Strategies and Contemporary Biomedical Applications

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