Incorporation of indomethacin into a mesoporous silica nanoparticle enhances the anti-inflammatory effect Indomethacin into a mesoporous silica

Junior, Almeida; Pereira, Poliana Marques; Tótoli, Vanessa de Souza; Neves, Edna Sousa; Monochio, Mayara; Alvarenga, Alef Winter Oliveira; Hori, Juliana Issa; Braz, Wilson Rodrigues; Rocha, Lucas A.; Nassar, Eduardo J.; Aldrovani, Marcela; Furtado, Ricardo Andrade

doi:10.1016/j.ejps.2020.105601

Cited by 8 publications

(3 citation statements)

References 40 publications

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“… 57 In some studies, elevated levels of ALT have been observed already several hours after administration of a single dose of NSAID. 58 , 59 Physiologically, urea and creatinine are filtered out of the blood by the kidneys. In renal disorders, when the kidneys are unable to excrete urea and creatinine properly, they are retained in the blood, and their levels become elevated.…”

Section: Discussionmentioning

confidence: 99%

Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]Pyridazinone Exert Anti-Inflammatory Activity without Acute Gastrotoxicity in the Carrageenan-Induced Rat Paw Edema Test

Szandruk-Bender¹,

Merwid-Ląd²,

Wiatrak³

et al. 2021

JIR

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Section: Discussionmentioning

confidence: 99%

Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]Pyridazinone Exert Anti-Inflammatory Activity without Acute Gastrotoxicity in the Carrageenan-Induced Rat Paw Edema Test

Szandruk-Bender¹,

Merwid-Ląd²,

Wiatrak³

et al. 2021

JIR

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“…It has been demonstrated that such a system may exert simultaneous and synergistic action on critical metabolic pathways which result in increasing of apoptotic effect via the co-delivery of several drugs [ 160 ]. The conjugation of anti-cancer drugs and anti-inflammatory agents has shown promising results [ 168 ]. Benova et al studied the co-delivery approach of 5-fluorouracil anticancer drug in combination with naproxen anti-inflammatory agent using β-cyclodextrin-modified SBA-15 mesoporous silica as a carrier [ 160 ].…”

Section: Mesoporous Material-based Drug Delivery Systems For Anti-inf...mentioning

confidence: 99%

Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Moritz

Geszke-Moritz

2022

Pharmaceutics

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Interest in the use of mesoporous materials as carriers of medicinal substances has been steadily increasing in the last two decades. Mesoporous carriers have application in the preparation of delivery systems for drugs from various therapeutic groups; however, their use as the carriers of anti-inflammatory agents is particularly marked. This review article, with about 170 references, summarizes the achievements in the application of mesoporous materials as the carriers of anti-inflammatory agents in recent years. This article will discuss a variety of mesoporous carriers as well as the characteristics of their porous structure that determine further use of these materials in the field of medical applications. Special attention will be paid to the progress observed in the construction of stimuli-responsive drug carriers and systems providing site-specific drug delivery. Subsequently, a review of the literature devoted to the use of mesoporous matrices as the carriers of anti-inflammatory drugs was carried out.

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“…Thus, IND has been widely used as an analgesic, anti-pyretic and antiinflammatory. However, the use of IND was limited, because it is one of BCS Class II drugs [2,3]. Many approaches have been described to increase the solubility and dissolution rate of IND by different formulation strategies in order to reduce adverse reactions, administration frequency, and/or the daily dose [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Cubosomes Dispersions as Enhanced Indomethacin Oral Delivery Systems: In vitro and Stability Evaluation

Alfagih

AlQuadeib

Aldosari

et al. 2021

JPRI

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Aims: To improve the dissolution of indomethacin through developing liquid indomethacin loaded cubosomes dispersion for oral delivery. Methodology: Glyceryl monooleate based indomethacin loaded cubosomes dispersion were prepared using Taguchi design to study the effect of indomethacin to the disperse phase ratio and poloxamer 407 (PLX%) concentrations on the particle size and entrapment efficiency (%EE). Furthermore, in vitro release in phosphate buffer (pH 6.8), and morphology were investigated. Also, the stability of indomethacin loaded cubosomes dispersions was examined after 6 months storage at 25°C in the dark. Results: The prepared indomethacin cubosomes dispersions were in the nanoscale (184.53±0.7 to 261.33±0.8 nm) with reasonable %EE (49.30±2.6 to 95.55±3.4 %). Moreover, a biphasic release profile was predominant for all formulations, up to 50% of payload released after 2h followed by a second continuous sustained release phase over 24h. The kinetics of indomethacin release was best explained by Higuchi model and the mechanism of drug release from these cubosomes dispersions was by fickian diffusion mechanism. In general, the indomethacin loaded cubosomes dispersions were stable after 6 months storage at 25°C in the dark. Conclusion: Indomethacin loaded cubosomes dispersions proved to be a successful platform to encapsulate and enhance the release of indomethacin with a good stability profile over 6 months.

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Incorporation of indomethacin into a mesoporous silica nanoparticle enhances the anti-inflammatory effect Indomethacin into a mesoporous silica

Cited by 8 publications

References 40 publications

Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]Pyridazinone Exert Anti-Inflammatory Activity without Acute Gastrotoxicity in the Carrageenan-Induced Rat Paw Edema Test

Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]Pyridazinone Exert Anti-Inflammatory Activity without Acute Gastrotoxicity in the Carrageenan-Induced Rat Paw Edema Test

Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Cubosomes Dispersions as Enhanced Indomethacin Oral Delivery Systems: In vitro and Stability Evaluation

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