Incorporation of metal-organic frameworks into electrospun chitosan/poly (vinyl alcohol) nanofibrous membrane with enhanced antibacterial activity for wound dressing application

Wang, Siyu; Yan, Fei; Ren, Ping; Li, Yi; Wu, Qiong; Fang, Xuedong; Chen, Fangfang; Wang, Ce

doi:10.1016/j.ijbiomac.2020.04.116

Cited by 109 publications

(39 citation statements)

References 37 publications

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“…The wound healing experiments in vivo using full-thickness skin wounds in mice demonstrated wound closures of 89.3% and 90.7% for commercial chitosan wound dressing and pristine chitosan–PVA nanofibers on the 12th day, respectively. The wound closure for chitosan–PVA nanofibrous material incorporated with Cu metal-organic frameworks was 99.1% without red and uneven scars [ 68 ].…”

Section: Fabrication Of Biopolymer-based Hybrid Nanofibersmentioning

confidence: 99%

Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Alven

Aderibigbe

2021

Polymers

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The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

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Section: Fabrication Of Biopolymer-based Hybrid Nanofibersmentioning

confidence: 99%

Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Alven

Aderibigbe

2021

Polymers

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“…Many conductive/semi-conductive materials have been reported to have antimicrobial activity through various mechanisms, including chemical release, electrostatic interactions and redox reactions, 257–261 and there are also a number of studies on in vivo wound healing using a dressing containing GO, 262–264 silver nanomaterials, 265–268 zinc oxide nanomaterials, 269 and metal organic frameworks. 270–272 With respect to rather older related studies, other schemes, such as electrets of hydroxyapatite, 273,274 were also reported to be effective as wound dressings. Such functional materials could be attractive options for electrical devices for wound healing, allowing a more effective approach, especially for refractory or infected wounds.…”

Section: Skin Devices Based On the Electrical Features Of The Skinmentioning

confidence: 99%

Electrical aspects of skin as a pathway to engineering skin devices

Abe

Nishizawa

2021

APL Bioengineering

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Skin is one of the indispensable organs for life. The epidermis at the outermost surface provides a permeability barrier to infectious agents, chemicals, and excessive loss of water, while the dermis and subcutaneous tissue mechanically support the structure of the skin and appendages, including hairs and secretory glands. The integrity of the integumentary system is a key for general health, and many techniques have been developed to measure and control this protective function. In contrast, the effective skin barrier is the major obstacle for transdermal delivery and detection. Changes in the electrical properties of skin, such as impedance and ionic activity, is a practical indicator that reflects the structures and functions of the skin. For example, the impedance that reflects the hydration of the skin is measured for quantitative assessment in skincare, and the current generated across a wound is used for the evaluation and control of wound healing. Furthermore, the electrically charged structure of the skin enables transdermal drug delivery and chemical extraction. This paper provides an overview of the electrical aspects of the skin and summarizes current advances in the development of devices based on these features.

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“…The MOFs based novel dressing materials showed increased antibacterial against S. aureus and E. coli, the most common bacterial species in wound infections. In animal studies, contrasted with commercial dressings of chitosan and chitosan/PVA fibers, these MOFs surface modified with fibers were more potent to heal the wound with minimum inflammation (Wang et al, 2020). In another recent study, Yang et al synthesized surface engineered MOF derived photo-responsive nanocarbon for safe, rapid, and synergistic chemophotothermal bacterial disinfection of wounds.…”

Section: Surface Engineered Mofs In Multi-functional Dressings For Efmentioning

confidence: 99%

Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

Chen

Cai

et al. 2020

Front. Bioeng. Biotechnol.

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Wounds present serious medical complications and their healing requires strategies that promote angiogenesis, deposition of collagen as well as re-epithelialization of wounds. Currently used conventional wound healing strategies have become less effective due to various issues associated with them. Thus, novel strategies are needed to be developed for early and effective healing of wounds. Metal-organic frameworks (MOFs), formed by linking of metal ions through organic bridging ligands, are highly tunable hybrid materials and have attracted more considerable scientific attention due to their charming and prominent properties, such as abundant pore structures and multiple functionalities. Surface engineering of MOFs with unique ligands can overcome issues associated with conventional wound healing methods, thus resulting in early and effective wound healing. This review has been undertaken to elaborate wound healing, and the use of surface engineered MOFs for effective and rapid wound healing. The process of wound healing will be discussed followed by a detailed review of recent literature for summarizing applications of surface engineered MOFs for wound healing. MOFs wound healing will be discussed in terms of their use as antibacterial agents, therapeutic delivery vehicles, and dressing systems in wound healing.

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Incorporation of metal-organic frameworks into electrospun chitosan/poly (vinyl alcohol) nanofibrous membrane with enhanced antibacterial activity for wound dressing application

Cited by 109 publications

References 37 publications

Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Electrical aspects of skin as a pathway to engineering skin devices

Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

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