1997
DOI: 10.1164/ajrccm.156.2.9606016
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Increase in Pulmonary Ventilation–Perfusion Inequality with Age in Healthy Individuals

Abstract: Arterial oxygen tension (PaO2) is known to decrease with age, and this is accompanied by a number of changes in mechanical properties of the lungs, including loss of elastic recoil and increase in closing volume. The changes in respiratory mechanics with age could induce greater ventilation/perfusion (VA/Q) mismatch and thus explain the decrease in PaO2. In 64 normal subjects aged 18 to 71 yr (lifetime nonsmokers with normal spirometry), we measured VA/Q inequality and arterial respiratory blood gases (PaO2 an… Show more

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Cited by 144 publications
(96 citation statements)
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“…18 The dispersion of the two distributions (pulmonary perfusion and alveolar ventilation) on a log scale (Log SDQ and Log SDV, respectively) were used as indices of V A /Q mismatch (upper limits of normal, 0.60 and 0.65, respectively) (dimensionless). 19 The difference among measured retentions and excretions of the inert gases corrected for the elimination of acetone, an overall descriptor of the combined dispersion of both blood flow and ventilation distributions, was calculated (normal values Ͻ3.0, dimensionless).…”
Section: Methodsmentioning
confidence: 99%
“…18 The dispersion of the two distributions (pulmonary perfusion and alveolar ventilation) on a log scale (Log SDQ and Log SDV, respectively) were used as indices of V A /Q mismatch (upper limits of normal, 0.60 and 0.65, respectively) (dimensionless). 19 The difference among measured retentions and excretions of the inert gases corrected for the elimination of acetone, an overall descriptor of the combined dispersion of both blood flow and ventilation distributions, was calculated (normal values Ͻ3.0, dimensionless).…”
Section: Methodsmentioning
confidence: 99%
“…The pulmonary gas exchange abnormality is characterised by arterial deoxygenation that may be mild, moderate or severe [3,5,[13][14][15][16]. There is an increased alveolar-arterial oxygen tension difference (PA-a,O 2 ).…”
Section: Definitionmentioning
confidence: 99%
“…Calculation of PA-a,O 2 is one of the most sensitive approaches for the detection of early arterial deoxygenation [3,5], since PA-a,O 2 can increase before arterial oxygen tension (Pa,O 2 ) itself becomes abnormally low. At sea level and while breathing room air, a resting PA-a,O 2 of o2.0 kPa (o15 mmHg) can be considered abnormal [15,16], but, for patients aged w64 yrs, a PA-a,O 2 of o2.7 kPa (o20 mmHg) can be recommended (table 1) [14]. However, an increased PA-a,O 2 alone is not sufficient to confirm the existence of HPS [13].…”
Section: Definitionmentioning
confidence: 99%
“…Increasing age has been associated with decreased arterial PO 2 , due to small airway closure [30], decreased alveolar surface [25] and decreased diffusing capacity of the lungs [31]. In our cohort, oxygenation derangements, as they were assessed by PaO 2 /FiO 2 ratio and A-aDO 2 , were not found to be different between age-groups.…”
Section: Discussionmentioning
confidence: 50%