Increase in Serum Levels of Autoantibodies after Attack of Seasonal Allergic Rhinitis in Patients with Graves’ Disease

Abstract

Background: The prevalence of allergic disease is increasing worldwide, but its influence on the clinical course of autoimmune diseases is unknown. Objective: The purpose of this study was to assess the effect of seasonal allergic rhinitis on the clinical course of Graves’ disease, which has been considered a Th2-dominant autoimmune disease. Methods: Ten patients with Graves’ disease, who were considered to be in a state of remission or near remission, were serially examined for 18 months starting from August. Five of them had seasonal allergic rhinitis due to Japanese cedar pollen, and the remaining patients had no such allergic disorders. Peripheral eosinophil counts, serum concentrations of cedar-pollen-specific IgE, anti-TSH-receptor antibody, anti-thyroid-peroxidase antibody and antithyroglobulin antibody were assessed at 2- to 4-month intervals. Serum thyroid hormones and TSH levels were also measured to evaluate disease activity. Results: All patients with pollinosis had attacks of allergic rhinitis caused by cedar pollen in early March. Subsequently, peripheral eosinophil counts, pollen-specific IgE activity and serum levels of anti-thyroid-peroxidase and antithyroglobulin autoantibodies markedly increased. Serum levels of anti-TSH-receptor antibody increased in 3 patients in association with an increase in serum thyroid hormones but were always negative in 2 patients. The control patients without pollinosis showed no consistent change of these parameters. Conclusions: Seasonal allergic rhinitis aggravated the clinical course of Graves’ disease and induced an increase in serum antithyroid autoantibody concentrations as well as an increase in pollen-specific IgE concentration. These data suggest that environmental antigens induce not only local allergic reactions, but also stimulate thyroid immune reactions toward Th2 proliferation, and finally aggravate Th2-dependent autoimmune thyroid disease.

Evaluating of Thyroid Function Tests and Thyroid Autoantibodies in Patients with Allergic Rhinitis

“…There was more association with Graves' disease in pollen allergies (22). In our study, among the patients in the rhinitis group, 48.7% has seasonal allergic rhinitis; 16.1% were allergic to perennial house dust mite; and the remaining 35.1% were allergic to house dust mite and/or fungi and/or pollen.…”

“…Among the patients with severe bronchial asthma, anti-TPO and anti-Tg levels are found to be high. These results suggest that environmental antigens do not only stimulate local allergic reactions; at the same time, they also stimulate Th2 cell proliferation in Graves' disease and exacerbate autoimmune thyroid reactions and Th2-related autoimmune thyroid diseases (13).…”

“…However, its effects on the clinical course of autoimmune diseases are not known (13). Allergic disorders are the inappropriate reactions of the immune system to the external antigens.…”

“…Takeoka et al (13) have indicated that seasonal allergic rhinitis has exacerbated the clinical course of Graves' disease. They have presented that allergic rhinitis has increased the serum antithyroid autoantibody and pollen-specific immunoglobulin E (IgE) concentrations.…”

The Prevalence and Characteristics of Allergy in Autoimmune Thyroid Diseases

“…The immune processes lead to thyroid tissue destruction due to the productions of proinflammatory IL-1, IL-6, IL-17 and TNFα cytokines and the increased apoptosis demonstrating Th1 dominance [3]. Elevated IgE levels in Graves' disease, can be regarded as inducing factors for hyperthyroidism and connect to higher TSH receptor antibody levels [4]. IgE deposits were demonstrated in eye muscle tissue derived from patients with ophthalmopathy [5].…”