Increase in the frequency of K‐ras codon 12 point mutation in colorectal carcinoma in elderly males in Japan: The 1990s compared with the 1960s

Kinoshita, Haruyuki; Yanagisawa, Akio; Watanabe, Toshiaki; Nagawa, Hirokazu; Oya, Mototsugu; Kato, Yukio; Muto, Tetsuichiro

doi:10.1111/j.1349-7006.2005.00037.x

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…The TRACC registry data provides an opportunity to examine this further. As reported by others, 18,19 we find an increased rate of RASmt in patients aged 75 or older, where 56% of patients were positive versus only 46% in the 60-74 year age group. We also report an impact of tumor side, with more RASmt found in patients with a right-sided primary.…”

Section: Kras Mutation Only 470 (90%) E366 Discussionsupporting

confidence: 89%

Impact of the evolution in RAS mutation analysis in Australian patients with metastatic colorectal cancer

Chong

Jalali

Wong

et al. 2022

Asia-Pac J Clncl Oncology

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Background RAS mutation testing now routinely informs the optimal management of metastatic colorectal cancer (mCRC), specifically the finding of a RAS mutation defines patients who will not benefit from treatment with an epidermal growth factor receptor inhibitor. Over time more RAS genes have been tested and more sensitive techniques used. Aims To review routine care RAS testing and results over time. Methods A retrospective analysis of the molecular data collected prospectively in the multi‐site Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) registry from 2009 to 2018 was undertaken. Patients with RAS data were further analyzed. In parallel, the RAS mutation status of patients enrolled in the Test Tailor Treat (TTT) program was examined for 2011–2018. Results Of 2908 patients in the TRACC registry, 1892 (65%) were tested, with 898 (47%) of tested patients found to be RAS mutant (RASmt). RAS data were available for 5935 TTT patients. Of the tested TRACC patients diagnosed in 2009 and 2010, 38% were RASmt. For each 2‐year period from 2011/2012 through to 2017/2018, the prevalence of RASmt in TRACC and TTT was 42% and 40% (2011/2012), 52% and 40% (2013/2014), 47% and 49% (2015/2016), and 47% and 49% (2017/2018). Conclusions Based on both TRACC and TTT data, the proportion of patients reported to have a RAS mutation increased from 2009 to 2015 but has remained relatively stable in recent years. The increased proportion of RASmt patients observed over time is likely largely driven by the uptake of extended RAS testing.

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Section: Kras Mutation Only 470 (90%) E366 Discussionsupporting

confidence: 89%

Impact of the evolution in RAS mutation analysis in Australian patients with metastatic colorectal cancer

Chong

Jalali

Wong

et al. 2022

Asia-Pac J Clncl Oncology

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“…Patients with Lynch Syndrome experience early-onset CRC as well as an increased risk of developing certain extracolonic cancers [7–17] In sporadic cancers, there are often point mutations in tumor suppressor genes and protooncogenes including K-ras, p53 and APC [18–23]. These mutations are seldom observed in Lynch Syndrome cancers [24–26].…”

Section: Introductionmentioning

confidence: 99%

Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients

Drescher

Sharma

Lynch

2010

Journal of Immunology Research

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High levels of microsatellite instability (MSI-high) are a cardinal feature of colorectal tumors from patients with Lynch Syndrome. Other key characteristics of Lynch Syndrome are that these patients experience fewer metastases and have enhanced survival when compared to patients diagnosed with microsatellite stable (MSS) colorectal cancer. Many of the characteristics associated with Lynch Syndrome including enhanced survival are also observed in patients with sporadic MSI-high colorectal cancer. In this review we will present the current state of knowledge regarding the mechanisms that are utilized by the host to control colorectal cancer in Lynch Syndrome and why these same mechanisms fail in MSS colorectal cancers.

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“…Differences in diagnosis might exist between the relatively small sampling period of 2 years in the Vietnamese and 12 years in the Japanese. In addition, an increase in the frequency of K- ras mutations in CRCs in the 1990s compared with that in the 1960s has been reported [ 26 ]. This implies that the frequency of genetic alterations may differ during different time periods.…”

Section: Discussionmentioning

confidence: 99%

Differences in K-rasand mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients

et al. 2014

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BackgroundThe incidence of early-onset (under 50 years of age) colorectal cancer (CRC) in the Vietnamese has been reported to be quite higher than that in the Japanese. To clarify the differences in genetic alterations between Vietnamese and Japanese CRCs, we investigated mutations in K-ras and mitochondrial DNA (mtDNA) and high-frequency microsatellite instability (MSI-H) in the CRCs of Vietnamese and Japanese patients.MethodsWe enrolled 60 Vietnamese and 233 Japanese patients with invasive CRCs. DNA was extracted from formalin-fixed, paraffin-embedded tissue sections. K-ras mutations were examined with PCR-single-strand conformation polymorphism analysis. mtDNA mutations and MSI-H were examined with microsatellite analysis using D310 and BAT-26, respectively.ResultsK-ras mutations were examined in 60 Vietnamese and 45 Japanese CRCs. The frequency of the mutations in the Vietnamese CRCs was significantly higher than that in the Japanese CRCs (8 of 24 [33%] vs 5 of 45 [11%], p =0.048). MSI-H was examined in 60 Vietnamese and 130 Japanese CRCs. The frequency of MSI-H in the Vietnamese CRCs was also significantly higher than that in the Japanese CRCs (6 of 27 [22%] vs 10 of 130 [8%], p =0.030). mtDNA mutations were examined in 60 Vietnamese and 138 Japanese CRCs. The frequency of mtDNA mutations in the Vietnamese CRCs was significantly higher than that in the Japanese CRCs (19 of 44 [43%] vs 11 of 133 [9%], p <0.001). There were no significant differences in clinicopathologic characteristics, such as age, sex, tumour location, and depth, in terms of tumours with/without each genetic alteration in the CRCs of the Vietnamese and Japanese patients.ConclusionsThese results indicate that the developmental pathways of CRCs in the Vietnamese may differ from those of CRCs in the Japanese.

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Increase in the frequency of K‐ras codon 12 point mutation in colorectal carcinoma in elderly males in Japan: The 1990s compared with the 1960s

Cited by 8 publications

References 20 publications

Impact of the evolution in RAS mutation analysis in Australian patients with metastatic colorectal cancer

Impact of the evolution in RAS mutation analysis in Australian patients with metastatic colorectal cancer

Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients

Differences in K-rasand mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients

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