Increase of collagen in diabetes-related traumatic ulcers after the application of liquid smoke coconut shell

Surboyo, Meircurius Dwi Condro; Arundina, Ira; Rahayu, Retno Pudji

doi:10.20473/j.djmkg.v50.i2.p71-75

Cited by 15 publications

(32 citation statements)

References 27 publications

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“…LS-CE in the previous researches showed to increase the fibroblasts, caused faster wound closure 36 and oral ulcer healing, 16 and increased the synthesis of collagen. 15 This study is a corroborating evidence that LS-CE can affect the healing of diabetic oral ulcer by affecting the inflammatory cell responses. The result of this study also confirmed the two previous studies that LS-CE also affects the macrophages by directly inhibiting the inflammatory process 28 and increasing the collagen density, 15 thus increasing the ulcer healing.…”

Section: Ls-ce Role In Fibroblasts Ernawati Et Alsupporting

confidence: 75%

Role of Inflammatory Cell Responses in Stimulating Fibroblasts in Diabetic Oral Ulcer after Treatment with Liquid Smoke of Coconut Endocarp: A Histological Assessment

et al. 2020

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Objective The liquid smoke of coconut endocarp (LS-CE) contains high antioxidants that promote oral ulcer healing in diabetics. This study reveals the profile of inflammatory cell responses to oral ulcer healing in diabetics under treatment with LS-CE. Materials and Methods A diabetic model was induced with alloxan. Treatment with LS-CE was performed on oral ulcer at a dose of 1 μL/g weight for 3, 5, and 7 days. The anti-inflammatory effect was tested on animal’s oral ulcer model by measuring the inflammatory cell responses of the neutrophils, macrophages, lymphocytes, and fibroblasts through histological assessment. Results The LS-CE stimulated the healing by simultaneously increasing the inflammatory cell responses. The numbers of neutrophils, macrophages, and fibroblasts after treatment for 7 days are higher than that after 3 days and 5 days (p < 0.01), but not for neutrophils. The LS-CE shows increase in the fibroblasts by hastening responses of macrophage recruitment by five times, but not neutrophil and lymphocyte recruitment. The higher phenolic compounds in LS-CE are responsible for increase in the proliferation of fibroblasts, as it hastens cellular responses of macrophages. Conclusions The application of LS-CE enables hastening of the healing of diabetic oral ulcer by stimulating the macrophages.

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Section: Ls-ce Role In Fibroblasts Ernawati Et Alsupporting

confidence: 75%

Role of Inflammatory Cell Responses in Stimulating Fibroblasts in Diabetic Oral Ulcer after Treatment with Liquid Smoke of Coconut Endocarp: A Histological Assessment

et al. 2020

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“… 19 Previous research has shown that topical treatment of LC-SS promotes oral ulcer healing, 15 by increasing the production of collagens. 14 Phenolic compounds in LC-SS demonstrate the ability to decrease TNF-α expression in diabetic oral ulcers by increasing macrophages responses and decreasing NF-κB expression. The hydroxyl group (-OH) is able to bind superoxide (O 2 - ) during signaling to produce proinflammatory cytokines such as TNF-α.…”

Section: Discussionmentioning

confidence: 99%

“…Topical treatment with BHCl 0.12% (Tantum Verde; Soho, Jakarta, Indonesia) and LC-SS was applied at a dose of 1μL/1 gr of body weight once a day for 5 days. 14…”

Section: Subject Treatment and Experimental Designmentioning

confidence: 99%

“…9 The effectiveness of topical drugs, such as mouthwash, gel even paste, for oral ulcer therapy is determined by its ability to adhesion and its absorption in the lesion, 11 and is able to provide analgesic effects rather than just anti-inflammatory drug. 9 Several studies have demonstrated that LC-SS possesses analgesic properties 12 in addition to the ability to stimulate fibroblast formation, 13 increase collagen, 14 and improve clinical oral ulcer healing. 15 In empirical studies, LC-SS is able to reduce pain during burn wound healing and can be used as a natural preservative in meat.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have demonstrated that LC-SS possesses analgesic properties 12 in addition to the ability to stimulate fibroblast formation, 13 increase collagen, 14 and improve clinical oral ulcer healing. 15 In empirical studies, LC-SS is able to reduce pain during burn wound healing and can be used as a natural preservative in meat.…”

Section: Introductionmentioning

confidence: 99%

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The Macrophage Responses during Diabetic Oral Ulcer Healing by Liquid Coconut Shell Smoke: An Immunohistochemical Analysis

et al. 2020

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Objectives Liquid coconut shell smoke (LC-SS) is used in natural food preservation for a long history. The purpose of this study was to analyze the role of LC-SS in macrophage responses during diabetic oral ulcer healing as medication. Materials and Methods Oral ulcers were induced in the labial lower mucosa of the research subjects using a round steel blade following diabetic induction by means of alloxan. Twenty-four diabetic Wistar rats presenting oral ulcers were divided into two groups, a test group, which was given topical treatment of LC-SS and a control group, which was given benzydamine hydrochloride (BHCl). The role of LC-SS in macrophages was assessed by means of immunohistochemistry for nuclear factor kappa B (NF-κB) and tumor necrosis factor-α (TNF-α) expression. Result LC-SS increased macrophages compared with BHCl (p = 0.000). The LC-SS affected only TNF-α expression by stimulating NF-κB expression (p = 0.046) but did not macrophage numbers (p = 0.861). Conclusion LC-SS has a stronger effect compared with BHCl on diabetic oral ulcer healing by increasing macrophage response to produce TNF-α while decreasing NF-κB expression.

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The hydroxypropyl methylcellulose-sorbitol thin film containing a coconut shell of liquid smoke for treating oral ulcer

Surboyo,

Mansur,

Kuntari

et al. 2024

JCIS Open

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Increase of collagen in diabetes-related traumatic ulcers after the application of liquid smoke coconut shell

Cited by 15 publications

References 27 publications

Role of Inflammatory Cell Responses in Stimulating Fibroblasts in Diabetic Oral Ulcer after Treatment with Liquid Smoke of Coconut Endocarp: A Histological Assessment

Role of Inflammatory Cell Responses in Stimulating Fibroblasts in Diabetic Oral Ulcer after Treatment with Liquid Smoke of Coconut Endocarp: A Histological Assessment

The Macrophage Responses during Diabetic Oral Ulcer Healing by Liquid Coconut Shell Smoke: An Immunohistochemical Analysis

The hydroxypropyl methylcellulose-sorbitol thin film containing a coconut shell of liquid smoke for treating oral ulcer

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