Increase of Resting Levels of Superoxide Anion in the Whole Blood of Patients With Decompensated Liver Cirrhosis

Monitoring oxidative stress across worsening child pugh class of cirrhosis

“…[14] A role of oxidative stress in the pathogenesis of chronic liver disease has been proposed by several authors using animal and human studies. [15][16][17] The aim of our study was to assess the changes, if any, in the levels of markers reflecting oxidative stress across worsening Child scores.…”

Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy

“…During the setting of liver disease, liver protein synthesis is decreased, thus diminishing the antioxidant capacity. Albumin, which constitutes close to 50 % of serum protein, is synthesized in the liver and significantly decreases during chronic liver disease (CLD) (Chen et al 1997). Albumin, an important transporter for several molecules and a regulator of plasma osmotic pressure, is also a powerful antioxidant, due to its cysteine and methionine residues (Roche et al 2008).…”

“…As circulating levels of superoxide are significantly increased in decompensated versus compensated cirrhotic patients (Chen et al 1997), in cirrhosis oxidative stress represents a systemic phenomenon associated with the severity of the liver disease.…”

Increase in Resting Levels of Superoxide Anion in the Whole Blood of Uremic Patients on Chronic Hemodialysis

“…Therefore, it is doubtful whether the results under this condition can reflect the physiological status. Recently, we developed a simple, sensitive method to detect superoxide anion in whole blood using an ultrasensitive CL analyzer and lucigenin amplification [23,24]. The assay can be performed in the absence of leukocyte isolation and stimulant administration.…”