Increase of the mitotic index of colonic mucosa after cholecystectomy

Abstract

This study was undertaken to assess possible modifications of the proliferative activity of colonic mucosa, which could be related to a suggested cancer-promoting role of cholecystectomy. The mitotic index (number of mitoses per 1000 gland cells) was evaluated in the colonic mucosa of 14 healthy subjects, 11 patients with cholelithiasis, before and 6 months after surgery, and 10 patients who had undergone cholecystectomy 2 or more years previously. The mitotic index of cholecystectomized patients was significantly higher than controls. It rose significantly within 6 months of cholecystectomy. The mitotic index of patients with cholelithiasis before surgery was similar to controls. These data suggest that cholecystectomy is followed by an enhancement in the proliferative activity of the colonic mucosa, which could play a cancer-promoting role.

Increased Colorectal Epithelial Cell Proliferation and Crypt Fission Associated with Obesity and Roux-en-Y Gastric Bypass

“…It has been shown that the mitotic index (measured by mitotic figure counting in mucosal sections) of colonic mucosa is increased following cholecystectomy (27). However, in our study, we did not detect any significant difference in crypt epithelial mitosis between RYGB patients who did or did not have a concurrent cholecystectomy (data not shown).…”

Tissue-specific DNA methylation loss during ageing and carcinogenesis is linked to chromosome structure, replication timing and cell division rates

“…As the enrichment analysis was performed using a fifth of the probes, we set the fraction of hypomethylated probes to 20% in the model. We assumed a mitotic index of 40%, which is considered an upper bound for cell division rate in several cancers ( 84 , 85 ). The maximum expected log 2 (odds ratio) that could be obtained with these parameters was ∼1.17.…”

The relationship between cholecystectomy and colon cancer: An Iowa study

“…This type of cellular damage enchances mitotic activity and marked hyperplasia, which may be a prelude to neoplasm. This hypothesis has gained support from a recent study of mitotic index Lee et al of colonic mucosa after cholecystectomy [40] and the cell kinetic study in explant cultures of the human colon mucosa under deoxycholic acid stimulation [41]. Alternatively, cholelithiasis may share risk factors with colon cancer [42].…”