2008
DOI: 10.1016/j.yexcr.2008.05.003
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Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription

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Cited by 42 publications
(35 citation statements)
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“…These changes were not related to altered ␣-or ␥-secretase activities, nor were there any obvious indications that a direct ␦OR-APP interaction in a variant-specific manner plays a role in the altered APP processing. Interestingly enough, the APP pro- cessing phenotype in the ␦OR-Cys27 variant-expressing cells is intriguingly similar to that observed previously with APP under pH-neutralized conditions (45), suggesting that these two conditions may share common mechanistic features. ␦OR-Cys27 variant-induced changes in APP processing can be suppressed by a long-term treatment with ␦OR-specific ligands via a mechanism involving altered trafficking of the receptor.…”
Section: Resultssupporting
confidence: 83%
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“…These changes were not related to altered ␣-or ␥-secretase activities, nor were there any obvious indications that a direct ␦OR-APP interaction in a variant-specific manner plays a role in the altered APP processing. Interestingly enough, the APP pro- cessing phenotype in the ␦OR-Cys27 variant-expressing cells is intriguingly similar to that observed previously with APP under pH-neutralized conditions (45), suggesting that these two conditions may share common mechanistic features. ␦OR-Cys27 variant-induced changes in APP processing can be suppressed by a long-term treatment with ␦OR-specific ligands via a mechanism involving altered trafficking of the receptor.…”
Section: Resultssupporting
confidence: 83%
“…Under those conditions in ammonium chloride-treated CHO cells, the accumulation specifically of APP C83, but not APP C99, was detected in conjunction with decreased A␤ and unaltered sAPP␣ levels. APP C99 was also partially converted to APP C83 through an ␣-secretase-mediated cleavage in CHO cells stably overexpressing APP C99 under pH-neutralizing conditions, explaining the decreased APP C99/C83 ratio (45). Consistent with this finding, it was recently shown that C99 and C89 are processed by ␣-secretase (ADAM10) to C83 (16).…”
Section: Vol 31 2011supporting
confidence: 55%
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“…Although not formally defined as direct targets, the glycogen synthase kinase3␤ (GSK3␤) (59,69,70), APP (59) itself, and BACE1 (59) are considered AICD-regulated genes. However, it has to be noted that other studies did not observe a nuclear transcriptional role of AICD at least with respect to the expression of some of the potential target genes (71)(72)(73).…”
Section: Aicd A␤42 and Tau Interactions With Dnamentioning
confidence: 79%