Increased albumin plasma efflux contributes to hypoalbuminemia only during early phase of sepsis in rats

Ruot, Benoît; Papet, Isabelle; Béchereau, Fabienne; Denis, Philippe; Buffière, Caroline; Gimonet, Johan; Glomot, Francoise; Elyousfi, Mimoun; Breuillé, Denis; Obled, Christiane

doi:10.1152/ajpregu.00483.2002

Cited by 39 publications

(24 citation statements)

References 27 publications

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“…The bacterial infection model set up in old rats is a typical inflammatory stress. In agreement with the literature (Aderka 1996;Breuillé et al 1998;Fenton and Golenbock 1998;Ruot et al 2002Ruot et al , 2003, sTNFR-1, positive acute phase proteins a 2 -macroglobulin, fibrinogen, and LBP increased after the bacterial injection, whereas the negative acute phase protein albumin decreased. These results confirm that the acute phase protein responses observed under combined endotoxic and dietary stress in our previous investigation were not inflammatory responses (Mayot et al 2007b).…”

Section: Discussionsupporting

confidence: 92%

Presence of age-associated low-grade inflammation does not worsen the body response to bacterial infection in old male rats

et al. 2010

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In the field of frailty, there is an underlying hypothesis that chronic low-grade inflammation contributes to bad outcomes in response to a stressor. The host response to an Escherichia coli infection was assessed in 24 month old male rats exhibiting a chronic low-grade inflammation and in non-inflamed control rats. Mortality, weight loss and sarcopenia were the main outcomes measured. The presence of chronic low-grade inflammation did not affect post-infection mortality, body weight loss and tissue mass decreases. Infection-induced modifications of plasma acute phase proteins concentrations were not higher in low-grade inflamed than non-inflamed rats. Absolute synthesis rates of tissue proteins were independent of the initial inflammatory status, except for liver 10 days after infection. Altogether, age-associated chronic low-grade inflammation in male rats did not worsen the body response to bacterial infection. These results suggest that chronic low-grade inflammation is not an aggravating factor of the spiraling process leading to frailty.

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Section: Discussionsupporting

confidence: 92%

Presence of age-associated low-grade inflammation does not worsen the body response to bacterial infection in old male rats

et al. 2010

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“…Whereas there is little information on albumin degradation at present, previous studies have indicated that the decrease in plasma albumin concentration observed during catabolic states is strongly related to an increase in albumin efflux, i.e. redistribution of albumin to the extravascular space, as well as to changes in the size of the intravascular fluid space [22][23][24]. Also, based primarily on studies in small animals, the common assumption regarding albumin synthesis has been a decrease in these situations, thus contributing to hypoalbuminaemia [1,3,5,6].…”

Section: Discussionmentioning

confidence: 99%

Synthesis rates of total liver protein and albumin are both increased in patients with an acute inflammatory response

et al. 2005

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The general perception that catabolism and inflammation are associated with a high synthesis rate of total liver protein and a low albumin synthesis rate has been challenged in recent years by several studies in man, indicating that the synthesis rate of albumin in response to a catabolic insult is increased rather than decreased. Thus changes in liver protein synthesis rates in conjunction with catabolism and acute inflammation in man need to be characterized better. The aim of the present study was to measure protein synthesis rates of total liver protein and albumin during a state of acute inflammation. Patients (n = 10) undergoing acute laparoscopic cholecystectomy due to acute cholecystitis were investigated. FSRs (fractional synthesis rates) of total liver protein (liver biopsy specimens) and albumin (plasma samples) were investigated as early as possible during the surgical procedure, using a flooding dose of L-[2H5]phenylalanine. The results were compared with a reference group of patients without cholecystitis undergoing elective laparoscopic cholecystectomy (n = 17). FSR of total liver protein was 60% higher (P < 0.001) and the FSR of albumin was 45% higher (P < 0.01) in the cholecystitis patients compared with the control group. In conclusion, the synthesis rates of total liver protein and albumin are both increased in patients with an acute general inflammatory reaction undergoing laparoscopic cholecystectomy.

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“…Therefore, unsaturated LPCs primarily associate with albumin instead of lipoproteins (32). Furthermore, a number of studies indicated that the rate of albumin degradation and albumin loss in tissue increased in patients with critical illnesses, such as sepsis (33)(34)(35). In addition, the concentration of albumin would return to normal values (32) as soon as the infection was controlled.…”

Section: Trend ------------------------------------------------------mentioning

confidence: 99%

Probiotic pre-administration reduces mortality in a mouse model of cecal ligation and puncture-induced sepsis

Chen

Gui

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. A number of clinical trials have demonstrated that the use of probiotics has the potential to prevent nosocomial infections. However, the mechanism underlying probiotic-induced anti-infection and sepsis remains to be investigated. In the present study, 200 µl/day of Lactobacillus rhamnosus GG (LGG) or normal saline (control) was orally administrated to 4-week-old C57BL6 mice 4 weeks prior to cecal ligation and puncture (CLP). A number of mice were sacrificed 24 h after CLP, and the remaining mice were used for survival studies. Ileum tissues were collected to evaluate the injury on the intestine. Blood samples were also obtained to investigate the changed metabolic pattern in mice that underwent different treatments using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). In the survival studies, the mortality of CLP-induced septic mice pretreated with LGG was significantly lower compared with untreated mice (P= 0.029). Ileum mucosal damage was evident in the control septic mice. Based on the data of UPLC-QTOF-MS, phosphatidylcholines were increased and lysophosphatidylcholines (LPCs) that contained polyunsaturated fatty acids were decreased in septic mice, whereas saturated fatty acid LPCs reveal no significant difference between septic and sham mice. In addition, the metabolic profile in the septic mice pretreated with LGG was much closer to that of sham mice compared with control septic mice. The results of the present study suggest that probiotic pre-administration reduces the mortality in septic mice by decreasing ileum mucosal damage, increasing the gut barrier integrity and altering global serum metabolic profiles.

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Increased albumin plasma efflux contributes to hypoalbuminemia only during early phase of sepsis in rats

Cited by 39 publications

References 27 publications

Presence of age-associated low-grade inflammation does not worsen the body response to bacterial infection in old male rats

Presence of age-associated low-grade inflammation does not worsen the body response to bacterial infection in old male rats

Synthesis rates of total liver protein and albumin are both increased in patients with an acute inflammatory response

Probiotic pre-administration reduces mortality in a mouse model of cecal ligation and puncture-induced sepsis

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