Increased brain tissue sodium concentration in Huntington's Disease — A sodium imaging study at 4T

Reetz, Kathrin; Romanzetti, Sandro; Dogan, Imis; Saß, Christian; Werner, Cornelius J.; Schiefer, Johannes; Schulz, Jörg B.; Shah, N. Jon

doi:10.1016/j.neuroimage.2012.07.009

Cited by 71 publications

(179 citation statements)

References 53 publications

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“…WM measurements from the hand‐drawn ROI analysis here are also in agreement with previous studies: for example, Qian et al showed 37.4 ± 2.9 vs. 38.6 ± 8.0 mM here. GM values also showed good agreement with the literature: 47.6 ± 7.1 for the caudate here vs. 52.0 ± 6.0 mM; and 40.9 ± 7.1 for the putamen here vs. 43.0 ± 3.0 mM . In general, differences between overall GM and the putamen are unsurprising due to cellular differences between deep GM and cortical GM: for example, the basal ganglia is permeated by a small amount of WM fiber bundles which would give a TSC that is a composite between WM and GM.…”

Section: Discussionsupporting

confidence: 85%

Measuring tissue sodium concentration: Cross‐vendor repeatability and reproducibility of ²³Na‐MRI across two sites

Riemer

McHugh

Zaccagna

et al. 2019

Magnetic Resonance Imaging

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Background Sodium MRI (23Na‐MRI)‐derived biomarkers such as total sodium concentration (TSC) have the potential to provide information on tumor cellularity and the changes in tumor microstructure that occur following therapy. Purpose To evaluate the repeatability and reproducibility of TSC measurements in the brains of healthy volunteers, providing evidence for the technical validation of 23Na‐MRI‐derived biomarkers. Study Type Prospective multicenter study. Subjects Eleven volunteers (32 ± 6 years; eight males, three females) were scanned twice at each of two sites. Field Strength/Sequence Comparable 3D‐cones 23Na‐MRI ultrashort echo time acquisitions at 3T. Assessment TSC values, quantified from calibration phantoms placed in the field of view, were obtained from white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF), based on automated segmentation of coregistered 1H T1‐weighted images and hand‐drawn regions of interest by two readers. Statistical Tests Coefficients of variation (CoVs) from mean TSC values were used to assess intrasite repeatability and intersite reproducibility. Results Mean GM TSC concentrations (52.1 ± 7.1 mM) were ∼20% higher than for WM (41.8 ± 6.7 mM). Measurements were highly repeatable at both sites with mean scan–rescan CoVs between volunteers and regions of 2% and 4%, respectively. Mean intersite reproducibility CoVs were 3%, 3%, and 6% for WM, GM, and CSF, respectively. Data Conclusion These results demonstrate technical validation of sodium MRI‐derived biomarkers in healthy volunteers. We also show that comparable 23Na imaging of the brain can be implemented across different sites and scanners with excellent repeatability and reproducibility. Level of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:1278–1284.

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Section: Discussionsupporting

confidence: 85%

Measuring tissue sodium concentration: Cross‐vendor repeatability and reproducibility of ²³Na‐MRI across two sites

Riemer

McHugh

Zaccagna

et al. 2019

Magnetic Resonance Imaging

View full text Add to dashboard Cite

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“…A very recent preliminary study showed that patients with Huntington's disease also present an increased TSC in the whole brain compared to healthy controls, in structurally affected regions of the brain, but also in some nonaffected regions.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Biomedical applications of sodium MRI in vivo

Madelin

Regatte

2013

Magnetic Resonance Imaging

222

310

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In this article, we present an up-to-date overview of the potential biomedical applications of sodium MRI in vivo. Sodium MRI is a subject of increasing interest in translational imaging research as it can give some direct and quantitative biochemical information on the tissue viability, cell integrity and function, and therefore not only help the diagnosis but also the prognosis of diseases and treatment outcomes. It has already been applied in vivo in most of human tissues, such as brain for stroke or tumor detection and therapeutic response, in breast cancer, in articular cartilage, in muscle and in kidney, and it was shown in some studies that it could provide very useful new information not available through standard proton MRI. However, this technique is still very challenging due to the low detectable sodium signal in biological tissue with MRI and hardware/software limitations of the clinical scanners. The article is divided in three parts: (1) the role of sodium in biological tissues, (2) a short review on sodium magnetic resonance, and (3) a review of some studies on sodium MRI on different organs/diseases to date.

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“…A very recent preliminary study [161] showed that patients with Huntington’s disease ( n = 13) also present increased TSC in the whole brain compared to healthy controls ( n = 13), in structurally affected regions of the brain, but also in some non-affected regions. Similar to the AD case, no satisfying explanation of these TSC increases could be proposed due to the limited data, low resolution and lack of differentiation between intra-cellular and extra-cellular sodium content.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Sodium MRI: Methods and applications

Madelin

Lee

Regatte

et al. 2014

Progress in Nuclear Magnetic Resonance Spectroscopy

190

209

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Sodium NMR spectroscopy and MRI have become popular in recent years through the increased availability of high-field MRI scanners, advanced scanner hardware and improved methodology. Sodium MRI is being evaluated for stroke and tumor detection, for breast cancer studies, and for the assessment of osteoarthritis and muscle and kidney functions, to name just a few. In this article, we aim to present an up-to-date review of the theoretical background, the methodology, the challenges and limitations, and current and potential new applications of sodium MRI.

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Increased brain tissue sodium concentration in Huntington's Disease — A sodium imaging study at 4T

Cited by 71 publications

References 53 publications

Measuring tissue sodium concentration: Cross‐vendor repeatability and reproducibility of ²³Na‐MRI across two sites

Measuring tissue sodium concentration: Cross‐vendor repeatability and reproducibility of ²³Na‐MRI across two sites

Biomedical applications of sodium MRI in vivo

Sodium MRI: Methods and applications

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Increased brain tissue sodium concentration in Huntington's Disease — A sodium imaging study at 4T

Cited by 71 publications

References 53 publications

Measuring tissue sodium concentration: Cross‐vendor repeatability and reproducibility of 23Na‐MRI across two sites

Measuring tissue sodium concentration: Cross‐vendor repeatability and reproducibility of 23Na‐MRI across two sites

Biomedical applications of sodium MRI in vivo

Sodium MRI: Methods and applications

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Product

Resources

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Measuring tissue sodium concentration: Cross‐vendor repeatability and reproducibility of ²³Na‐MRI across two sites

Measuring tissue sodium concentration: Cross‐vendor repeatability and reproducibility of ²³Na‐MRI across two sites