Increased epicardial adipose tissue volume is associated with PR interval prolongation

Hung, Wei‐Chin; Tang, Wei‐Hua; Wang, Chao-Ping; Liu, Lu; Chung, Fu‐Mei; Lu, Yung‐Chuan; Hsu, Chia‐Chang; Tsai, I‐Ting; Jhuo, Shih-Jie; Lai, Wen‐Ter; Lee, Yau-Jiunn; Ya, Teng-Hung

doi:10.25011/cim.v38i1.22575

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…Increased epicardial adipose tissue, general obesity, and central obesity result in prolonged PR interval . Abdominal obesity may be one of the risk factors for a prolonged QT interval in premenopausal women, and prolongation of QT interval is common in obesity .…”

Section: Discussionmentioning

confidence: 99%

Comprehensive identification of pleiotropic loci for body fat distribution using the NHGRI‐EBI Catalog of published genome‐wide association studies

et al. 2018

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We conducted a hypothesis-free cross-trait analysis for waist-to-hip ratio adjusted for body mass index (WHR adjBMI ) loci derived through genome-wide association studies (GWAS). Summary statistics from published GWAS were used to capture all WHR adjBMI single-nucleotide polymorphisms (SNPs), and their proxy SNPs were identified. These SNPs were used to extract cross-trait associations between WHR adjBMI SNPs and other traits through the NHGRI-EBI GWAS Catalog. Pathway analysis was conducted for pleiotropic WHR adjBMI SNPs. We found 160 WHR adjBMI SNPs and 3675 proxy SNPs. Cross-trait analysis identified 239 associations, of which 100 were for obesity traits. The remaining 139 associations were filtered down to 101 unique linkage disequilibrium block associations, which were grouped into 13 categories: lipids, red blood cell traits, white blood cell counts, inflammatory markers and autoimmune diseases, type 2 diabetes-related traits, adiponectin, cancers, blood pressure, height, neuropsychiatric disorders, electrocardiography changes, urea measurement, and others. The highest number of cross-trait associations were found for triglycerides (n = 10), high-density lipoprotein cholesterol (n = 9), and reticulocyte counts (n = 8). Pathway analysis for WHR adjBMI pleiotropic SNPs found immune function pathways as the top canonical pathways. Results from our original methodology indicate a novel genetic association between WHR adjBMI and reticulocyte counts and highlight the pleiotropy between abdominal obesity, immune pathways, and other traits.

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Section: Discussionmentioning

confidence: 99%

Comprehensive identification of pleiotropic loci for body fat distribution using the NHGRI‐EBI Catalog of published genome‐wide association studies

et al. 2018

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“…Of interest, the thickness of the EAT is a predictor of fatal and nonfatal coronary events in the general population, regardless of the traditional cardiovascular risk factors [18][19][20][21]. Increased EAT volume is associated with a lengthened electrocardiogram PR interval [22], suggesting that EAT can interfere with electrical conduction through the heart, modifying the heartbeat.…”

Section: Introductionmentioning

confidence: 99%

Early Appearance of Epicardial Adipose Tissue through Human Development

et al. 2021

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Background: Epicardial adipose tissue (EAT) is a visceral fat depot with unique anatomic, biomolecular and genetic features. Due to its proximity to the coronary arteries and myocardium, dysfunctional EAT may contribute to the development and progression of cardiovascular and metabolic-related adiposity-based chronic diseases. The aim of this work was to describe, by morphological techniques, the early origin of EAT. Methods: EAT adipogenesis was studied in 41 embryos from 32 gestational days (GD) to 8 gestational weeks (GW) and in 23 fetuses until full term (from 9 to 36 GW). Results: This process comprises five stages. Stage 1 appears as mesenchyme at 33–35 GD. Stage 2 is characterized by angiogenesis at 42–45 GD. Stage 3 covers up to 34 GW with the appearance of small fibers in the extracellular matrix. Stage 4 is visible around the coronary arteries, as multilocular adipocytes in primitive fat lobules, and Stage 5 is present with unilocular adipocytes in the definitive fat lobules. EAT precursor tissue appears as early as the end of the first gestational month in the atrioventricular grooves. Unilocular adipocytes appear at the eighth gestational month. Conclusions: Due to its early origin, plasticity and clinical implications, factors such as maternal health and nutrition might influence EAT early development in consequence.

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“…While vast amounts of data show strong evidence of a distinct positive association between EFT amount and both the incidence and the recurrence of atrial fibrillation [19][20][21], only a few studies have investigated the role of EFT in CCAs. Hung et al analyzed the association between EFT amount and PR prolongation in a cohort of 287 patients referred for coronary CT analysis for exclusion of CAD [22]. The authors found that higher EFT volume was independently associated with PR prolongation after adjustment for the cardiovascular risk factors, age, sex, and BMI.…”

Section: Discussionmentioning

confidence: 99%

Epicardial fat volume is associated with preexisting atrioventricular conduction abnormalities and increased pacemaker implantation rate in patients undergoing transcatheter aortic valve implantation

Weferling

Rolf

Fischer‐Rasokat

et al. 2021

Int J Cardiovasc Imaging

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Epicardial fat tissue (EFT) is a highly metabolically active fat depot surrounding the heart and coronary arteries that is related to early atherosclerosis and adverse cardiac events. We aimed to investigate the relationship between the amount of EFT and preexisting cardiac conduction abnormalities (CCAs) and the need for new postinterventional pacemaker in patients with severe aortic stenosis planned for transcatheter aortic valve implantation (TAVI). A total of 560 consecutive patients (54% female) scheduled for TAVI were included in this retrospective study. EFT volume was measured via a fully automated artificial intelligence software (QFAT) using computed tomography (CT) performed before TAVI. Baseline CCAs [first-degree atrioventricular (AV) block, right bundle branch block (RBBB), and left bundle branch block (LBBB)] were diagnosed according to 12-lead ECG before TAVI. Aortic valve calcification was determined by the Agatston score assessed in the pre-TAVI CT. The median EFT volume was 129.5 ml [IQR 94–170]. Baseline first-degree AV block was present in 17%, RBBB in 10.4%, and LBBB in 10.2% of the overall cohort. In adjusted logistic regression analysis, higher EFT volume was associated with first-degree AV block (OR 1.006 [95% CI 1.002–1.010]; p = 0.006) and the need for new pacemaker implantation after TAVI (OR 1.005 [95% CI 1.0–1.01]; p = 0.035) but not with the presence of RBBB or LBBB. EFT volume did not correlate with the Agatston score of the aortic valve. Greater EFT volume is associated independently with preexisting first-degree AV block and new pacemaker implantation in patients undergoing TAVI. It may play a causative role in degenerative processes and the susceptibility of the AV conduction system.

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Increased epicardial adipose tissue volume is associated with PR interval prolongation

Cited by 10 publications

References 34 publications

Comprehensive identification of pleiotropic loci for body fat distribution using the NHGRI‐EBI Catalog of published genome‐wide association studies

Comprehensive identification of pleiotropic loci for body fat distribution using the NHGRI‐EBI Catalog of published genome‐wide association studies

Early Appearance of Epicardial Adipose Tissue through Human Development

Epicardial fat volume is associated with preexisting atrioventricular conduction abnormalities and increased pacemaker implantation rate in patients undergoing transcatheter aortic valve implantation

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