2011
DOI: 10.1242/jcs.080762
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Increased ER–mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

Abstract: There were errors published in J. Cell Sci. 124, 2143Sci. 124, -2152 In the section given below, PtdIns(3,4,5)P 3 was on four occasions incorrectly printed instead of the correct Ins(1,4,5)P 3 .We apologise for this mistake. Increased mitochondrial Ca2+ drives the adaptive metabolic boost observed during early phases of ER stress Increases in mitochondrial respiration and ATP production are often consequences of increases in mitochondrial Ca 2+ (Green and Wang, 2010). In order to determine whether early phase… Show more

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Cited by 509 publications
(414 citation statements)
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“…Indeed, mitochondrial Ca 2+ levels control the activity of three deshydrogenases of Krebs cycle (Denton 2009), thus influencing ATP synthesis. In agreement, increased ER-mitochondrial coupling was shown to promote mitochondrial respiration and bioenergetics during early phases of ER stress (Bravo et al 2011). Conversely, genetic or pharmacological inhibition of IP3R altered mitochondrial function, lowering ATP production and triggering autophagy (Cardenas et al 2010).…”
Section: Role Of Mam In Energy Metabolism and Redox Statusmentioning
confidence: 75%
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“…Indeed, mitochondrial Ca 2+ levels control the activity of three deshydrogenases of Krebs cycle (Denton 2009), thus influencing ATP synthesis. In agreement, increased ER-mitochondrial coupling was shown to promote mitochondrial respiration and bioenergetics during early phases of ER stress (Bravo et al 2011). Conversely, genetic or pharmacological inhibition of IP3R altered mitochondrial function, lowering ATP production and triggering autophagy (Cardenas et al 2010).…”
Section: Role Of Mam In Energy Metabolism and Redox Statusmentioning
confidence: 75%
“…Thus, IP3R-mediated Ca 2+ release is important for cellular bioenergetics. Furthermore, this bioenergetic response seems important for cellular adaptation during early stage of ER stress as moderate ER stress increased ER-mitochondria interactions to increase Ca 2+ transfer and enhance mitochondrial respiration (Bravo et al 2011). However, sustained activation of ER stress impaired mitochondrial metabolism (Wang & Pantopoulos 2011), suggesting a strong link between metabolic insufficiency and ER stress-mediated apoptosis.…”
Section: Role Of Mam In Energy Metabolism and Redox Statusmentioning
confidence: 99%
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“…(ii) Mitochondria are isolated from their natural environment that includes close associations with the cytoskeleton and other organelles (e.g. the endoplasmic reticulum) that contribute to the determination of mitochondrial morphology and the rate of respiration [52], and therefore have a direct effect on ROS produced by ETC. (iii) Substrates and ADP are administered at saturating concentrations that would never be encountered in vivo.…”
Section: Problems Measuring Ros: In Vitro Vs In Vivo Measurementsmentioning
confidence: 99%
“…For this reason, mitochondria can be juxtaposed to ER by specific linkers and kept at a given distance (between 10 and 25 nm). It has been shown that decreasing the distance between ER and mitochondria enhances apoptotic susceptibility of the cell [287] or can help the cell in overcoming stress conditions by ensuring higher ATP supply [288]. The proteins mediating or influencing ER-mitochondria interactions are the subject of great interest, and their number is progressively increasing (Fig.…”
Section: Mitochondriamentioning
confidence: 99%