Increased Excretion of 5-Hydroxyindoleacetic Acid in Urine of Children with Untreated Coeliac Disease

Enterochromaffin cells in the duodenal mucosa of children with coeliac disease.

“…Increased urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), a metabolite of 5-hydroxytryptamine (5-HT), has been reported in both adults and children with untreated coeliac disease (Haverback and Davidson, 1958;Kowlessar et al, 1958;Haverback et al, 1960;Pimparker et al, 1961;Scriver, 1961;Sleisenger, 1961;Kowlessar et al, 1964;Benson et al, 1964;Challacombe et al, 1972;Challacombe et al, 1975). Clinical recovery after the introduction of a gluten-free diet is accompanied by a fall in urinary 5-HIAA (Sleisenger, 1961;Benson et al, 1964;Kowlessar et al, 1964;Challacombe et al, 1972).…”

Increased tissue concentrations of 5-hydroxytryptamine in the duodenal mucosa of patients with coeliac disease.

“…An association with villous flattening in other gastrointestinal disorders has not yet been excluded. However, previous studies of urinary 5-HIAA excretion in children suggest that raised excretion may be a specific manifestation of coeliac disease (Challacombe et al, 1972).…”

“…5-HT is metabolised by the enzyme monoamine oxidase in the tissues to 5-hydroxy-indolylacetaldehyde, which is further oxidised and excreted in the urine as 5-HIAA. Raised levels of 5-HT in the blood (Pimparker et al, 1961;Warner and Cohen, 1962) and 5-HIAA in the urine (Haverback and Davidson, 1958;Haverback et al, 1960;Pimparker et al, 1961;Scriver, 1961;Sleisenger, 1961;Benson et al, 1964;Kowlessar et al, 1964;Challacombe et al, 1972;Challacombe et al, 1975) have been reported in patients with untreated coeliac disease. Clinical recovery after the introduction of a gluten-free diet was accompanied by a fall in blood 5-HT (Pimparker et al, 1961) and urinary 5-HIAA (Sleisenger, 1961;Benson et al, 1964;Kowlessar et al, 1964;Challacombe et al, 1972).…”

“…Increased urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), a metabolite of 5-hydroxytryptamine (5-HT), has been reported in both adults and children with untreated coeliac disease (Haverback and Davidson, 1958;Haverback et al, 1960;Pimparker et al, 1961;Scriver, 1961;Sleisenger, 1961;Benson et al, 1964;Kowlessar et al, 1964;Challacombe et al, 1972). Clinical recovery after the introduction of a gluten-free diet was accompanied by a fall in urinary 5-HIAA (Sleisenger, 1961;Benson et al, 1964;Kowlessar et al, 1964;Challacombe et al, 1972).…”

“…Clinical recovery after the introduction of a gluten-free diet was accompanied by a fall in urinary 5-HIAA (Sleisenger, 1961;Benson et al, 1964;Kowlessar et al, 1964;Challacombe et al, 1972). Raised blood levels of 5-HT in coeliac disease (Pimparker et al, 1961;Warner and Cohen, 1962) also return to normal after gluten withdrawal from the diet.…”