Increased frequency of lymphocyte micronuclei in workers producing reinforced polyester resin with low exposure to styrene.

Högstedt, Benkt; Åkesson, Bengt; Axell, K; Gullberg, Bo; Mitelman, Felix; Pero, Ronald W.; Skerfving, Staffan; Welinder, Hans

doi:10.5271/sjweh.2414

Cited by 44 publications

(12 citation statements)

References 11 publications

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“…The in creased rates of micronuclei in this study suggest that the styrene exposure of the workers was too low to induce chromo somal breaks but high enough to cause dis turbances of the mitotic spindle appara tus. Our results confirm the findings by Hogstedtet al [7], who found an increased rate of micronuclei among workers with low exposure to styrene.…”

Section: ]supporting

confidence: 83%

“…Analysis of micronuclei was performed accord ing to the method described by Hogstedt et al [7). Pe ripheral lymphocytes were cultured in the same me dium as for chromosome analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Styrene and styrene oxide have been found to induce sister chromatid ex changes (SCE) in lymphocytes in vitro [12], but the effect on SCEs in vivo is more uncertain and in need of further investiga tion [1,10]. Increased rates of micronuclei in lymphocytes have been observed after styrene exposure in vivo [7,11] and in vit ro [9].…”

mentioning

confidence: 99%

“…Hogstedt et al [7], employing a new micronucleus method based on the analy sis of lymphocytes with preserved cyto plasm, found an increased rate of micro nuclei among workers with a low exposure to styrene. The mean styrene concentra tion in the work room air was 13 ppm.…”

mentioning

confidence: 99%

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Chromosomal Aberrations in Lymphocytes of Workers Exposed to Low Levels of Styrene

Nordenson

Beckman²

1984

Hum Hered

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Chromosomal aberrations were studied in lymphocytes of 15 workers exposed to styrene and 13 controls. The average styrene concentration in the work room air was 24 ppm, and the levels of urinary mandelic acid were below 2 mmol/l. No significant increase in the rates of gaps and breaks was found. However, the rate of micro-nuclei was significantly increased, which indicates that the mitotic spindle mechanism may be more sensitive to styrene and its metabolites than DNA.

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Section: ]supporting

confidence: 83%

“…Analysis of micronuclei was performed accord ing to the method described by Hogstedt et al [7). Pe ripheral lymphocytes were cultured in the same me dium as for chromosome analysis.…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Chromosomal Aberrations in Lymphocytes of Workers Exposed to Low Levels of Styrene

Nordenson

Beckman²

1984

Hum Hered

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“…Six out of 20 exposed workers were smokers, with a mean consumption o f eight (ran ge [3][4][5][6][7][8][9][10][11][12][13] cigarett es per day. Eleven out of 22 referents were smo kers, with a mean consumption of 12 (range [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] cigar ettes per da y. Of th e exposed subjects 13 had had radiographic examinations du ring the last year, and th ree regularly took drug s (theophyllin, terbutalin, pidolol , insulin).…”

Section: Subjects and Samplingmentioning

confidence: 99%

Cytogenetic and hematological effects in plastics workers exposed to styrene.

Hagmar¹,

Högstedt²,

Welinder³

et al. 1989

Scand J Work Environ Health

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Single‐strand breaks, chromosome aberrations, sister‐chromatid exchanges, and micronuclei in blood lymphocytes of workers exposed to styrene during the production of reinforced plastics

Mäki‐Paakkanen¹,

Norppa²,

Walles³

et al. 1991

Environ and Mol Mutagen

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Chromosome aberrations (CA), micronuclei (MN, cytokinesis-block [CB] method), and sister-chromatid exchanges (SCE) were analysed in blood lymphocytes of 17 workers and 17 control subjects. The mean urinary mandelic acid level (average 9.4 mmol/l) and styrene glycol in blood (average 2.5 mumol/l) implied exposure to about 300 mg/m3 of styrene in the plant. The number of CA was significantly higher in non-smoking workers compared with nonsmoking controls. A significant correlation was observed between duration of exposure and individual CA level of all workers. No significant effects were observed in MN or SCE. Single-strand breaks (SSB) in DNA of isolated lymphocytes were studied in nine of the workers and eight of the controls by the DNA-unwinding technique. The results showed an increase in SSB among the exposed workers. The present findings support earlier reports on the increase of structural CA in blood lymphocytes of workers in the reinforced plastic industry, and also show that SSBs are elevated in such workers.

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Increased frequency of lymphocyte micronuclei in workers producing reinforced polyester resin with low exposure to styrene.

Cited by 44 publications

References 11 publications

Chromosomal Aberrations in Lymphocytes of Workers Exposed to Low Levels of Styrene

Chromosomal Aberrations in Lymphocytes of Workers Exposed to Low Levels of Styrene

Cytogenetic and hematological effects in plastics workers exposed to styrene.

Single‐strand breaks, chromosome aberrations, sister‐chromatid exchanges, and micronuclei in blood lymphocytes of workers exposed to styrene during the production of reinforced plastics

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