1984
DOI: 10.1159/000153458
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Chromosomal Aberrations in Lymphocytes of Workers Exposed to Low Levels of Styrene

Abstract: Chromosomal aberrations were studied in lymphocytes of 15 workers exposed to styrene and 13 controls. The average styrene concentration in the work room air was 24 ppm, and the levels of urinary mandelic acid were below 2 mmol/l. No significant increase in the rates of gaps and breaks was found. However, the rate of micro-nuclei was significantly increased, which indicates that the mitotic spindle mechanism may be more sensitive to styrene and its metabolites than DNA.

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Cited by 31 publications
(2 citation statements)
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“…Moreover, increased rates of chromosom e aberrat ion s have been found in wo rkers exposed to styrene (3,8). On the other hand, animal tests of carcinogenicity have been inconclusive (5).…”
mentioning
confidence: 99%
“…Moreover, increased rates of chromosom e aberrat ion s have been found in wo rkers exposed to styrene (3,8). On the other hand, animal tests of carcinogenicity have been inconclusive (5).…”
mentioning
confidence: 99%
“…Six out of 20 exposed workers were smokers, with a mean consumption o f eight (ran ge [3][4][5][6][7][8][9][10][11][12][13] cigarett es per day. Eleven out of 22 referents were smo kers, with a mean consumption of 12 (range [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] cigar ettes per da y. Of th e exposed subjects 13 had had radiographic examinations du ring the last year, and th ree regularly took drug s (theophyllin, terbutalin, pidolol , insulin).…”
Section: Subjects and Samplingmentioning
confidence: 99%