Mortality of workers exposed to styrene in the manufacture of glass-reinforced plastics.

Coggon, David; Osmond, Clive; Pannett, Brian; Simmonds, Stephanie; Winter, P D; Acheson, E D

doi:10.5271/sjweh.2067

Cited by 41 publications

(21 citation statements)

References 8 publications

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“…There was no support for an increased risk for breast cancer, which was similar to the results of previous cohort studies among female workers [8,17,18,24,37]. An association has been proposed in a study using occupational titles on death certi®cates as the source of exposure information [6].…”

Section: Discussionsupporting

confidence: 79%

Cancer incidence among Finnish workers exposed to aromatic hydrocarbons

Anttila

Pukkala

Riala

et al. 1998

International Archives of Occupational and Environmental Health

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The data are not supportive of an overall increase in the cancer risk for these solvents, even though we cannot rule out site-specific associations with the rectum, pancreas, and nervous system. There is supporting evidence in the epidemiology literature for pancreatic cancer risk and heavy exposure to styrene. More studies are warranted on solvents, with detailed information on lifetime exposures and habits being collected whenever possible.

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Section: Discussionsupporting

confidence: 79%

Cancer incidence among Finnish workers exposed to aromatic hydrocarbons

Anttila

Pukkala

Riala

et al. 1998

International Archives of Occupational and Environmental Health

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“…158,159 Bond et al 165 examined cohorts from 4 US styrene plants and observed a significantly increased relative risk (RR 5 2.45, 95% CI: 1.07-5.65) of multiple myeloma in workers exposed to styrene at the Michigan manufacturing location only; however, other studies reported overall nonsignificant relative risk estimates at or below 1.0. 89,134,[166][167][168] Formaldehyde was not found to be linked with multiple myeloma in US or British factory workers, [169][170][171] or in Danish case-control studies. 89,90 Hauptmann et al 171 did not observe a significant exposure-response relationship with formaldehyde peak exposure, average exposure intensity, cumulative exposure or duration of exposure.…”

Section: Organic Solventsmentioning

confidence: 90%

Multiple myeloma: A review of the epidemiologic literature

et al. 2007

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Multiple myeloma, a neoplasm of plasma cells, accounts for 15% of lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Incidence rates increase with age, particularly after age 40, and are higher in men, particularly African American men. The etiology is unknown with no established lifestyle, occupational or environmental risk factors. Although several factors have been implicated as potentially etiologic, findings are inconsistent. We reviewed epidemiologic studies that evaluated lifestyle, dietary, occupational and environmental factors; immune function, family history and genetic factors; and the hypothesized precursor, monoclonal gammopathies of undetermined significance (MGUS). Because multiple myeloma is an uncommon disease, etiologic assessments can be difficult because of small numbers of cases in occupational cohort studies, and few subjects reporting exposure to specific agents in case-control studies. Elevated risks have been reported consistently among persons with a positive family history of LHC. A few studies have reported a relationship between obesity and multiple myeloma, and this may be a promising area of research. Factors underlying higher incidence rates of multiple myeloma in African Americans are not understood. The progression from MGUS to multiple myeloma has been reported in several studies; however, there are no established risk factors for MGUS. To improve our understanding of the causes of multiple myeloma, future research efforts should seek the causes of MGUS. More research is also needed on the genetic factors of multiple myeloma, given the strong familial clustering of the disease. ' 2007 Wiley-Liss, Inc.Key words: multiple myeloma; epidemiology Multiple myeloma is a malignancy of plasma cells that results in an overproduction of light and heavy chain monoclonal immunoglobulins. The specific immunoglobulin secreted by the malignant cell is the M-protein, named in reference to its monoclonal characteristics. It is found in the serum and/or urine of persons affected with multiple myeloma.

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“…Results of previous studies of lymphatic and hematopoietic cancer in styrene-exposed workers [reviewed in Cohen et al, 2002 andIARC, 2002] have varied widely, including a statistically significant deficit of deaths [Coggon et al, 1987] and an association of increased mortality with longer latency and higher average level of exposure [Kogevinas et al, 1994].…”

Section: Discussionmentioning

confidence: 99%