Increased Intraocular Pressure Induced by Repository Corticosteroids

Herschler, Jonathan

doi:10.1016/0002-9394(76)90669-3

Cited by 80 publications

(35 citation statements)

References 4 publications

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“…Herschler 28 investigated 12 patients who demonstrated a steroid response to injected corticosteroid and showed that the duration and severity of response was inversely related to preparation solubilityFthis was despite 10 of the patients having had extensive topical treatment prior to the injection without a pressure rise. Herschler's findings implied that topical corticosteroid treatment could not be used as a screening method to exclude any subsequent pressure response with depot steroid injections.…”

Section: Different Preparationsmentioning

confidence: 99%

“…29 In the case of repository corticosteroids, the steroid may have to be surgically removed. 28 If cessation of steroid therapy is not possible, then methods of reducing the effects of the corticosteroid need to be considered.…”

Section: Cessation Of Corticosteroid Treatmentmentioning

confidence: 99%

“…[70][71][72] With the increasing popularity of intravitreal triamcinolone injections, 23,24 vitrectomy may prove useful in preventing glaucoma in selected cases.…”

Section: Filtration Surgerymentioning

confidence: 99%

See 2 more Smart Citations

Corticosteroid-induced glaucoma: a review of the literature

Kersey

Broadway

2005

Eye

382

228

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The intraocular pressure rise that can complicate the use of topical or systemic corticosteroid has been recognised for 50 years. More recently, following isolation of the myocilin gene (previously known as the trabecular meshwork inducible glucocorticoid response or TIGR gene), there has been renewed interest in this steroid-responsive phenomenon. Furthermore, the currently fashionable use of injectable intraocular steroids in the management of clinically significant subretinal fluid and macular oedema has resulted in an increased incidence. Animal studies, cell biology, molecular biology, and an improved knowledge of genetics have provided a better understanding of the mechanisms behind the response. The purpose of this review is to describe the risk factors for developing corticosteroid-induced glaucoma, to discuss the underlying mechanisms and genetics of the condition and to present management options.

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Section: Different Preparationsmentioning

confidence: 99%

Section: Cessation Of Corticosteroid Treatmentmentioning

confidence: 99%

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Corticosteroid-induced glaucoma: a review of the literature

Kersey

Broadway

2005

Eye

382

228

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“…44,46 If it is not possible to excise them, filtering surgery is advised to control IOP. Glaucoma due to intravitreal triamcinolone injections is medically managed, although role of pars plana vitrectomy has also been documented.…”

mentioning

confidence: 99%

Steroid-induced Glaucoma: An Avoidable Irreversible Blindness

Pandav¹,

Kaur²,

Kaushik³

et al. 2017

Journal of Current Glaucoma Practice

198

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Steroids are a group of anti-inflammatory drugs, commonly used to treat ocular and systemic conditions. Unmonitored use of steroids especially in eye drop formulations is common in situations when it is easily available over-the-counter, resulting in undesirable side effects.Among the ocular side effects, cataract and glaucoma are common. Steroid-induced ocular hypertension was reported in 1950, when long-term use of systemic steroid was shown to increase the intraocular pressure (IOP). Chronic administration of steroids in any form with raised IOP can cause optic neuropathy resulting in steroid-induced glaucoma.This review describes the pathophysiology and epidemiology of steroid-induced glaucoma, recognition of side effects, and principles of management. The purpose is to familiarize all clinicians with the potential dangers of administering steroids without monitoring the eye and the dangers of irreversible blindness in some instances of habitual self-prescription by patients.

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“…Although both studies are not adequately powered to detect rare complications, these complications were not observed. An increase in intraocular pressure (IOP) after topical or systemic administration of corticosteroids is of particular concern (Herschler, 1976). Patients who receive subTenon's capsule injections of corticosteroids may not respond to maximal antiglaucomatous therapy and, therefore, may require surgical excision of the depot because of a persistently elevated IOP (Akduman et al, 1996).…”

Section: Introductionmentioning

confidence: 99%