Increased risk of kidney damage among Chinese adults with simple renal cyst

Kong, Xianglei; Ma, Xiaojing; Zhang, Chengyin; Hong, Soon-Kwang; Gong, Xiaojie; Xu, Dongmei

doi:10.1007/s11255-018-1880-3

Cited by 16 publications

(26 citation statements)

References 32 publications

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“…Furthermore, SRC was correlated with proteinuria (OR 1.59; 95% CI 1.30–1.95) and DeGFR (OR 1.97; 95% CI 1.56–2.47) after adjusted for potential confounders. Our results also demonstrated that maximum diameter (per 1 cm increase), bilateral location, and multiple cysts significantly correlated with DeGFR [18]. However, cross-sectional study cannot explore the causal relationship or provide an insight into the mechanisms responsible for the observed associations.…”

Section: Discussionmentioning

confidence: 75%

“…Rapid GFR decline has also been shown to be associated with CVD and all-cause mortality [17]. Previous cross-sectional observational studies demonstrated a correlation between SRC and renal injury (proteinuria or renal insufficiency) [7,18]. However, controversy remains regarding the role and possible mechanisms relating these factors to the development of renal cysts [9].…”

Section: Introductionmentioning

confidence: 99%

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Association between simple renal cyst and kidney damage in a Chinese cohort study

Chen

et al. 2019

Renal Failure

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Background: The presence of simple renal cyst (SRC) has been associated to renal dysfunction, but the results were inconsistent. Accordingly, we conducted a longitudinal cohort study to explore the association between SRC and kidney damage. Methods: A total of 4274 adults (aged 45.4 ± 13.6 years) without chronic kidney disease at baseline were enrolled in 2008. SRC was assessed by ultrasonography. Logistic regression analysis were applied to explore the relationships between SRC and indicators of kidney damage (proteinuria and renal insufficiency), and also with relatively rapid decline in renal function (defined as the lowest quartile of △eGFR). Results: During 5 years of follow-up, participants in the SRC group had higher incidence of proteinuria (5.2% versus 2.4%, p = 0.004) and renal insufficiency (3.8% versus 0.97%, p < 0.001) compared with control group. SRC was correlated with proteinuria (OR 2.24; 95% CI 1.34–3.75) and renal insufficiency (OR 4.0; 95% CI 2.11–7.58) in univariable analysis, despite that the correlation was not significant after adjusted for traditional kidney disease risk factors. Furthermore, after adjusted for potential confounders, maximum diameter of the cyst (≥2.2 cm) was significantly associated with rapid decline in renal function (OR 2.19; 95% CI 1.24–3.87). Conclusions: Participants with SRC may be associated with higher incidence of proteinuria and renal insufficiency. This relationship may be obscured by age and other traditional risk factors. Higher diameter of the cysts contributed to more rapid decline in renal function of SRC participants.

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Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Association between simple renal cyst and kidney damage in a Chinese cohort study

Chen

et al. 2019

Renal Failure

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“…Moreover, Kong et al [3] managed a large sample crosssectional study about renal cysts, whose results showed the prevalence of it among Chinese adults was 10.5% and renal cysts were significantly correlated with renal damage: the estimated glomerular filtration rate (eGFR) of 5.7% patients who with more than one renal cyst was decreased under 60 ml/min/1.73m 2 . Nowadays, according to the morphological description of renal cysts, cysts of Bosniak III, IV are symptomatic and even malignant to some extent [4].…”

Section: Introductionmentioning

confidence: 99%

Aspiration-sclerotherapy versus laparoscopic de-roofing in the treatment of renal cysts: which is better?

et al. 2020

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Background: To compare the clinical efficiency between aspiration-sclerotherapy (AS) and laparoscopic de-roofing (LD) in the management of renal cysts through meta-analysis of comparative studies. Method: A comprehensive literature search was performed by PubMed, MEDLINE, Ovid and Web of Science for relevant studies published up to January 2020. The statistical analyses were conducted with Review Manager 5.3.0 and Stata 15.1. The sensitivity analysis was also carried out to confirm the reliability of this Meta-analysis. Results: Our searches of literature generated 6 studies (1547 patients incorporated) comparing AS with LD in the impacts of renal cyst therapy. Of these, 6 studies contained 1106 and 441 patients who were treated with AS and LD, respectively. The outcome of this meta-analysis indicated that LD group was superior in symptomatic successful rate [Odds Ratio (OR): 0.28; 95%Confidence Interval (CI): 0.09 to 0.86; P = 0.03), radiological successful rate (OR: 0.06; 95%CI: 0.02 to 0.15; P < 0.01) and recurrence rate (OR: 6.08; 95%CI: 2.81 to 13.15; p < 0.01). Nevertheless, AS group had shorter treatment time [Mean Difference (MD):-51.10; 95% CI:-73.01 to − 29.20; p < 0.01]. No statistically significant difference was showed in the rate of complications (OR: 3.19; 95% CI: 0.39 to 25.88; P = 0.28). Conclusions: In our meta-analysis, LD had higher symptomatic successful rate, radiological successful rate as well as lower recurrence rate than AS, while the treatment time was longer.

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“…There is a paucity of evidence about how cysts impact renal function over time, and this is likely to persist due to ethical, practical, and cost challenges associated with screening healthy or low‐risk individuals for asymptomatic renal cysts in routine practice 21 . In the general population, some cross‐sectional studies have reported inferior kidney function in individuals with renal cysts compared to those without cysts, 22‐26 while others have reported no association between cysts and renal function 27‐29 . Evidence regarding postdonation renal function among donors with cysts is limited to a single German study, which found no difference in serum creatinine among 25 donors with renal cysts compared to those without cysts (N = 243) after a mean follow‐up time of 2.8 years (1.37 vs 1.33 mg/dL in donors with and without cysts, respectively) 30 .…”

Section: Introductionmentioning

confidence: 99%

Long‐term renal function in living kidney donors with simple renal cysts: A retrospective cohort study

Waldram

Thomas

et al. 2020

Clinical Transplantation

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Simple (Bosniak I) renal cysts are considered acceptable in living kidney donor selection in terms of cancer risk. However, they tend to increase in number and size over time and might compromise renal function in donors. To clarify their implications for long-term renal function, we characterized the prevalence of renal cysts in 454 individuals who donated at our center from 2000 to 2007. We estimated the association between the presence of cysts in the kidney remaining after nephrectomy (ie, retained cysts) and postdonation eGFR trajectory using mixed-effects linear regression. Donors with retained cysts (N = 86) were older (P < .001) and had slightly lower predonation eGFR (median 94 vs 98 mL/min/1.73 m 2 , P < .01) than those without cysts. Over a median 7.8 years, donors with retained cysts had lower baseline eGFR (−8.7 −5.6 −2.3 mL/min/1.73 m 2 , P < .01) but similar yearly change in eGFR (−0.4 0.02 0.4 mL/min/1.73 m 2 , P = .2) compared to those without retained cysts. Adjusting for predonation characteristics, there was no difference in baseline eGFR (P = .6) or yearly change in eGFR (P > .9). There continued to be no evidence of an association when we considered retained cyst(s) ≥10 mm or multiple retained cysts (all P > .05). These findings reaffirm current practices of accepting candidates with simple renal cysts for donor nephrectomy.

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Increased risk of kidney damage among Chinese adults with simple renal cyst

Abstract: The study revealed that SRC significantly correlated with kidney damage and special attention should be paid among Chinese adults with SRC.

Cited by 16 publications

References 32 publications

Association between simple renal cyst and kidney damage in a Chinese cohort study

Association between simple renal cyst and kidney damage in a Chinese cohort study

Aspiration-sclerotherapy versus laparoscopic de-roofing in the treatment of renal cysts: which is better?

Long‐term renal function in living kidney donors with simple renal cysts: A retrospective cohort study

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