Increased serum selenium levels are associated with reduced risk of advanced liver fibrosis and all-cause mortality in NAFLD patients: National Health and Nutrition Examination Survey (NHANES) III

Reja, Mishal; Makar, Michael; Visaria, Aayush; Rustgi, Vinod K.

doi:10.1016/j.aohep.2020.07.006

Cited by 36 publications

(26 citation statements)

References 25 publications

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“…Other studies have shown an inverse association of serum Se with metabolic co-morbidities. In an analysis of 33,944 patients recruited from the Third NHANES, NAFLD was diagnosed by sonography after the exclusion of other liver diseases [ 68 ]. The odds ratio of advanced liver fibrosis (fibrosis score of >0.676) was significantly reduced with increasing serum Se concentration; OR (95% CI) 0.55 (0.32, 0.94) in the highest vs the lowest Se quartile.…”

Section: What We Can Learn From Epidemiology On the Relationship Betw...mentioning

confidence: 99%

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The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities

2022

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Section: What We Can Learn From Epidemiology On the Relationship Betw...mentioning

confidence: 99%

“…The odds ratio of advanced liver fibrosis (fibrosis score of >0.676) was significantly reduced with increasing serum Se concentration; OR (95% CI) 0.55 (0.32, 0.94) in the highest vs the lowest Se quartile. The relationship was significant regardless of BMI [ 68 ].…”

Section: What We Can Learn From Epidemiology On the Relationship Betw...mentioning

confidence: 99%

The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities

2022

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“…The beginning of the “second hit” is based on steatosis. It further deepens the liver damage through the oxidative stress and inflammatory response induced by lipid peroxidation, causes mitochondrial dysfunction, and gradually develops NAFLD into NASH [ 4 , 35 ]. One of the most important characteristics of cell oxidative stress is the massive production of ROS in cells [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway

Wang

Liu

et al. 2022

Antioxidants

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Nonalcoholic fatty liver disease (NAFLD) occurs when excess fat is stored in the liver and it is strongly linked with metabolic syndrome and oxidative stress. Selenium (Se) is an essential micronutrient in animals, which has a variety of biological functions, including antioxidant and anti-inflammatory. However, the exact effect of dietary selenium on NAFLD and the underlying molecular mechanism are not yet clear. Herein, we fed a high-fat diet (HFD) to C57BL/6 mice to construct an in vivo NAFLD model, treated AML-12 cells with palmitic acid (PA) to construct an in vitro NAFLD model, and AML-12 cells were stimulated with H2O2 to induce hepatocyte oxidative stress and then treated with adequate selenium. We observed that adequate selenium significantly improved the hepatic injury and insulin resistance in HFD mice, and decreased the fat accumulation and the expression of lipogenic genes in PA-induced AML-12 cells. Meanwhile, selenium significantly inhibited the production of reactive oxygen species (ROS), inhibited apoptosis, and restored mitochondrial number and membrane potential in PA- induced AML-12 cells. In addition, selenium can promote selenoproteinP1 (SEPP1) synthesis to regulate the Kelch-like ECH-associated protein 1 (KEAP1)/NF-E2-related factor 2 (NRF2) pathway, so as to defend against hepatocyte oxidative stress. These findings suggest that dietary selenium supplementation can effectively resist hepatic injury and insulin resistance during NAFLD development, and regulate the KEAP1/NRF2 pathway to resist oxidative stress by promoting SEPP1 synthesis.

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“…With an insufficient intake of selenium in the body, the amount of selenoproteins decreases and can, therefore, affect the immune system by decreasing the development and functions of the thymus responsible for the production of macrophages and lymphocytes [ 1 , 2 ]. Extensive studies have indicated that selenium deficiency is an important contributing factor to the pathogenesis of numerous chronic diseases, such as cancer [ 3 , 4 ], cardiovascular diseases, diabetes, and liver diseases [ 5 , 6 ], as well as other disorders [ 3 , 7 ]. On the contrary, the excessive intake of selenium may cause oxidative damage, cytotoxicity, and increase DNA damage, often leading to nail fragility and hair loss [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, the results are not always consistent and its relationship with different severities of chronic liver diseases has been controversial. In the early stage of chronic liver diseases, some evidence linked lower blood selenium levels to fatty liver diseases compared to controls [ 5 , 16 ], while other studies found no or even a positive association of selenium levels and non-alcoholic fatty liver disease (NAFLD) [ 17 ]. In addition, some of the studies have investigated the association between selenium intake and the risk of chronic liver diseases but came out with inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

Selenium Status in Patients with Chronic Liver Disease: A Systematic Review and Meta-Analysis

Lin

Lian

et al. 2022

Nutrients

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Background: The potential role of selenium in preventing chronic liver diseases remains controversial. This meta-analysis aimed to summarize the available evidence from observational studies and intervention trials that had evaluated the associations between body selenium status and chronic liver diseases. Methods: We comprehensively searched MEDLINE, Embase, Web of Science, and Cochrane Library from inception to April 2021. The study protocol was registered at PROSPERO (CRD42020210144). Relative risks (RR) for the highest versus the lowest level of selenium and standard mean differences (SMD) with 95% confidence intervals (CI) were pooled using random-effects models. Heterogeneity and publication bias were evaluated using the I2 statistic and Egger’s regression test, respectively. Results: There were 50 studies with 9875 cases and 12975 population controls in the final analysis. Patients with hepatitis (SMD = −1.78, 95% CI: −2.22 to −1.34), liver cirrhosis (SMD = −2.06, 95% CI: −2.48 to −1.63), and liver cancer (SMD = −2.71, 95% CI: −3.31 to −2.11) had significantly lower selenium levels than controls, whereas there was no significant difference in patients with fatty liver diseases (SMD = 1.06, 95% CI: −1.78 to 3.89). Moreover, the meta-analysis showed that a higher selenium level was significantly associated with a 41% decrease in the incidence of significant advanced chronic liver diseases (RR = 0.59, 95% CI: 0.49 to 0.72). Conclusion: Our meta-analysis suggested that both body selenium status and selenium intake were negatively associated with hepatitis, cirrhosis, and liver cancer. However, the associations for fatty liver diseases were conflicting and need to be established in prospective trials.

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Increased serum selenium levels are associated with reduced risk of advanced liver fibrosis and all-cause mortality in NAFLD patients: National Health and Nutrition Examination Survey (NHANES) III

Cited by 36 publications

References 25 publications

The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities

The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities

Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway

Selenium Status in Patients with Chronic Liver Disease: A Systematic Review and Meta-Analysis

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