Increased strength of erythrocyte aggregates in blood of patients with inflammatory bowel disease

Maharshak, Nitsan; Arbel, Yaron; Shapira, Itzhak; Berliner, Shlomo; Ben‐Ami, Ronen; Yedgar, Saul; Barshtein, Gregory; Dotan, Iris

doi:10.1002/ibd.20838

Cited by 15 publications

(12 citation statements)

References 45 publications

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“…The association between the strength of large RBCs aggregates and the inflammatory status and the high plasma fibrinogen concentration was also observed in patients with inflammatory bowel disease where a detrimental microcirculatory blood flow is present in the intestinal microvasculature [41].…”

Section: Cross-sectional Clinical Studiesmentioning

confidence: 74%

“…From cross-sectional and longitudinal studies erythrocyte aggregation is (i) considered an independent risk factor for AMI, increasing over time in transmural myocardial survivors, (ii) evidenced as an independent predictor of recurrent cardiovascular events [67,68,78], and (iii) associated with inflammation response [41,52].…”

Section: Longitudinal Clinical Studiesmentioning

confidence: 99%

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Erythrocyte as a link between basic and clinical research

Saldanha

Almeida

2011

Clinical Hemorheology and Microcirculation

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We review the major hemorheological experimental studies that show the erythrocyte aggregation as a link between basic and clinical research. The results of the clinical cross-sectional and longitudinal studies presented here will highlight the possible association between erythrocyte aggregation and plasma fibrinogen. Basic studies conducted in vitro are also mentioned as for its relevance in answering questions raised in clinical settings, as well as and in understanding the underlying influent factors in the erythrocyte tendency to aggregate and disaggregate.

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Section: Cross-sectional Clinical Studiesmentioning

confidence: 74%

Section: Longitudinal Clinical Studiesmentioning

confidence: 99%

Erythrocyte as a link between basic and clinical research

Saldanha

Almeida

2011

Clinical Hemorheology and Microcirculation

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“…The association between the strength of large RBCs aggregates and the high plasma fibrinogen concentration was observed in patients with inflammatory bowel disease with detrimental microcirculatory blood flow in the intestinal microvasculature [94]. RBC aggregation was reported to be a biomarker of cardiovascular disease due to its association with other cardiovascular risk factors as observed in obesity, hypertension, dislipidemia and diabetes [95][96][97][98].…”

Section: Erythrocyte Membrane Properties and Functionsmentioning

confidence: 99%

Instrumental analysis applied to erythrocyte properties

Saldanha¹

2015

JCB

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The properties, structure and functions of the erythrocyte or red blood cell (RBC) have been known and evaluated by using simpler to more sophisticated technical devices. Microscopy, flow cytometry, spectrometry, spectroflurometry, aggregometer, ektacytometer zeta potential, amperometry, electrophoresis and centrifugation, are apparatus used to qualitatively and quantitatively characterize RBC, based on the principles of light transmission, light scattering spectroscopy, light absorption, fluorescence, light polarization, shear stress, shear rate, charge and molecular weight gradients. There is a symbiosis between the chemical, the physical and the mechanical principles of those instrumental analysis and the RBC properties to be measured. Here we briefly exemplify the relationship between the biochemical, biophysical and mechanical based techniques and the properties of the erythrocyte in healthy and disease.

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“…The increase in erythrocyte aggregation underlies disorders of rheological properties of blood that lead to degradation of tissue oxygenation [5,6] . There are few scientific data regarding the enhanced erythrocyte aggregation during IBD [7][8][9] . The similar data on children with IBD have not been found.…”

Section: Introductionmentioning

confidence: 99%

Aggregation in Children with Inflammatory Bowel Disease

Levin¹,

Поповичева²,

Соснина³

et al. 2018

IJHT

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Purpose: The aim of our research was to study the level of erythrocyte aggregation in blood of children with inflammatory bowel disease (IBD). Materials and methods: The study included 37 patients of both sexes ages 6 to 17 with IBD (17 with CD and 20 with UC). Blood was drawn after the hospitalization of patients and at the end of the treatment before their discharge. Erythrocyte aggregation was studied using a rheoscope constructed using the method of H. Schmid-Schönbein et al. at modification of G.Y. Levin et al. The process of aggregation was recorded during hydrodynamic mixing and upon its stop. The process of erythrocyte disaggregation was recorded when creating sheer stress set at the exact rate. The morphology of aggregates in autologous plasma was studied using a light microscope. The state of erythrocyte cytoskeleton was studied by the method of thermo induction. The state of erythrocyte membranes was determined by photometry on the laser aggregometer. Results: It was established that a significant increase in the degree and rate of aggregation of erythrocytes is observed at IBD. In the course of treatment aggregation of erythrocytes is normalized in children with UC, but remains elevated at CD. The aggregation character changes at IBD-pathological structures of aggregates appear along with the rouleaux. A correlation between ESR, fibrinogen concentration and the degree of erythrocyte aggregation was found. It was established that hyperaggregation of erythrocytes in IBD was caused by changes not only in plasma factors, but also in the cytoskeleton and in the erythrocyte membrane. Conclusion: Thus, disorders of the rheological properties of blood are an important factor in the pathogenesis of IBD in children causing ischemic damage to the intestine. This gives grounds for recommending the use of additional methods for combating hypoxia and microcirculatory disturbances during IBD.

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Increased strength of erythrocyte aggregates in blood of patients with inflammatory bowel disease

Abstract: The strength of RBC aggregates is increased in patients with IBD and correlates with the intensity of the acute phase response. This could contribute to bowel damage in these diseases.

Cited by 15 publications

References 45 publications

Erythrocyte as a link between basic and clinical research

Erythrocyte as a link between basic and clinical research

Instrumental analysis applied to erythrocyte properties

Aggregation in Children with Inflammatory Bowel Disease

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