Increased visfatin and leptin in pregnancies complicated by pre-eclampsia

Adalı, Ertan; Yıldızhan, Recep; Kolusarı, Ali; Kurdoğlu, Mertihan; Buğdaycı, Güler; Şahin, Hanım Güler; Kamacı, Mansur

doi:10.1080/14767050902994622

Cited by 48 publications

(45 citation statements)

References 29 publications

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“…Many studies have shown that visfatin may play an important role in placentation for normal pregnancy, although its role has not been clearly determined (42)(43)(44)(45). In this respect we can consider the possibility that administered visfatin during superovulation contributes to improved fertility potential by positively affecting normal placentation.…”

Section: Discussionmentioning

confidence: 94%

Administration of visfatin during superovulation improves developmental competency of oocytes and fertility potential in aged female mice

Choi

Joo

Sun

et al. 2012

Fertility and Sterility

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Section: Discussionmentioning

confidence: 94%

Administration of visfatin during superovulation improves developmental competency of oocytes and fertility potential in aged female mice

Choi

Joo

Sun

et al. 2012

Fertility and Sterility

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“…Thus visfatin has been reported to cause upregulation of pro-inflammatory and pro-contractile cytokines [26].The visfatin gene (in amnion epithelial cells) is also upregulated in response to inflammatory stimuli and stretch, suggesting a role in pre-tem labour [56]. Pregnancy and infection-associated preterm labour are associated with increased levels of visfatin, and visfatin or leptin changes have been reported in pregnancies complicated by preeclampsia, foetal growth restriction and gestational diabetes mellitus [24][25][26]28,29,31,[57][58][59][60]. However, direct extrapolation of the effects of circulating or local visfatin on labour onset and delivery need further data and in vivo studies.…”

Section: Discussionmentioning

confidence: 95%

Inhibitory effect of visfatin and leptin on human and rat myometrial contractility

et al. 2015

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“…14 Previous studies reviewed the contribution of visfatin/NAMPT in PE. 15 Most findings provide evidence for increased circulating visfatin levels [16][17][18][19][20] in patients with PE, although decreased serum visfatin levels 21 or visfatin expression have also been reported in PE. 22 Moreover, other studies found no differences in circulating visfatin levels when normal pregnant were compared with patients with PE.…”

Section: Introductionmentioning

confidence: 94%

Effects of NAMPT polymorphisms and haplotypes on circulating visfatin/NAMPT levels in hypertensive disorders of pregnancy

et al. 2015

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Dysregulation of adipocytokines may be associated with endothelial dysfunction in women with preeclampsia (PE), who are at increased risk of future cardiovascular disease. Visfatin, an adipocytokine with a potential cardiovascular role, is also known as nicotinamide phosphorybosil transferase (NAMPT). NAMPT gene polymorphisms affect circulating visfatin/NAMPT levels in obesity. Most findings provide evidence for increased visfatin/NAMPT circulating levels in PE. However, no previous study has tested the hypothesis that NAMPT polymorphisms affect visfatin/NAMPT levels in hypertensive disorders of pregnancy. We studied the effects of the NAMPT polymorphisms T>C (rs1319501) and A>G (rs3801266), and the haplotypes formed by them on visfatin/NAMPT levels and whether these genetic markers are associated with gestational hypertension (GH) and PE. We studied 212 healthy pregnant (HP), 181 patients with GH and 208 with PE. Genotypes were determined by Taqman allele discrimination assays. Plasma visfatin/NAMPT levels were measured by ELISA. No significant differences in visfatin/NAMPT levels were found among the groups. However, higher visfatin/NAMPT levels (P<0.05) were found in GH patients carrying the AG or the GG genotypes for the rs3801266 polymorphism or the 'T, G' haplotype. The TC and CC genotypes and the C allele for the rs1319501 polymorphism were more frequent in the HP than in the PE group (P<0.05). Moreover, the 'C, A' haplotype was also more frequent in the HP than in the PE group (P<0.01). Our findings suggest that although the rs3801266 polymorphism and the 'T, G' haplotype affect visfatin/NAMPT levels in GH, the rs1319501 polymorphism and the 'C, A' haplotype affect the susceptibility to PE.

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Increased visfatin and leptin in pregnancies complicated by pre-eclampsia

Abstract: These findings suggest that increased maternal levels of leptin and visfatin may be involved in the pathogenesis of pre-eclampsia, and measurement of these adipokines may be useful in assessment of the severity of disease.

Cited by 48 publications

References 29 publications

Administration of visfatin during superovulation improves developmental competency of oocytes and fertility potential in aged female mice

Administration of visfatin during superovulation improves developmental competency of oocytes and fertility potential in aged female mice

Inhibitory effect of visfatin and leptin on human and rat myometrial contractility

Effects of NAMPT polymorphisms and haplotypes on circulating visfatin/NAMPT levels in hypertensive disorders of pregnancy

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