Increases in pharyngeal
<i>Neisseria gonorrhoeae</i>
positivity in men who have sex with men, 2011–2015: observational study

Comninos, Nicholas B; Garton, Linda; Guy, Rebecca; Callander, Denton; Fairley, Christopher K; Grulich, Andrew E.; Donovan, Basil; Goddard, Sian Louise; Rutherford, Alison; Templeton, David J

doi:10.1136/sextrans-2019-054107

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…to limit the spread of infection as well as to detect gonococcal AMR. This 3-site testing should ideally use molecular diagnostics for the extragenital samples and be routine in MSM, considered in women particularly if sexual contacts of gonorrhoea patients, and be guided based on sexual history, risk, travel history and symptoms or signs in all other patients [8,12,[52][53][54].…”

Section: Discussionmentioning

confidence: 99%

Associations between antimicrobial susceptibility/resistance of Neisseria gonorrhoeae isolates in European Union/European Economic Area and patients’ gender, sexual orientation and anatomical site of infection, 2009–2016

et al. 2021

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Background The emergence and spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae, nationally and internationally, is a serious threat to the management and control of gonorrhoea. Limited and conflicting data regarding the epidemiological drivers of gonococcal AMR internationally have been published. We examined the antimicrobial susceptibility/resistance of gonococcal isolates (n = 15,803) collected across 27 European Union/European Economic Area (EU/EEA) countries in 2009–2016, in conjunction to epidemiological and clinical data of the corresponding patients, to elucidate associations between antimicrobial susceptibility/resistance and patients’ gender, sexual orientation and anatomical site of infection. Methods In total, 15,803 N. gonorrhoeae isolates from the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP), 2009–2016, were examined. Associations between gonococcal susceptibility/resistance and patients’ gender, sexual orientation and anatomical site of infection were investigated using univariate and multivariate logistic regression analysis. Statistical significance was determined by Pearson χ2-test or Fisher’s exact test with two-tailed p-values of < 0.05 indicating significance. Results The overall gonococcal resistance from 2009 to 2016 was 51.7% (range during the years: 46.5–63.5%), 7.1% (4.5–13.2%), 4.3% (1.8–8.7%), and 0.2% (0.0–0.5%) to ciprofloxacin, azithromycin, cefixime, and ceftriaxone, respectively. The level of resistance combined with decreased susceptibility to ceftriaxone was 10.2% (5.7–15.5%). Resistance to cefixime and ciprofloxacin, and resistance combined with decreased susceptibility to ceftriaxone were positively associated with urogenital infections and heterosexual males, males with sexual orientation not reported and females (except for ciprofloxacin), i.e. when compared to men-who-have-sex-with-men (MSM). Azithromycin resistance was positively associated with heterosexual males, but no association was significant regarding anatomical site of infection. Conclusions Overall, sexual orientation was the main variable associated with gonococcal AMR. Strongest positive associations were identified with heterosexual patients, particularly males, and not MSM. To provide evidence-based understanding and mitigate gonococcal AMR emergence and spread, associations between antimicrobial susceptibility/resistance and patients’ gender, sexual orientation and anatomical site of infection need to be further investigated in different geographic settings. In general, these insights will support identification of groups at increased risk and targeted public health actions such as intensified screening, 3-site testing using molecular diagnostics, sexual contact tracing, and surveillance of treatment failures.

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Section: Discussionmentioning

confidence: 99%

Associations between antimicrobial susceptibility/resistance of Neisseria gonorrhoeae isolates in European Union/European Economic Area and patients’ gender, sexual orientation and anatomical site of infection, 2009–2016

et al. 2021

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“…Despite a well‐described body of research on STI prevalence among MSM [11‐13], there are few published studies of incident STI infection among MSM and TGW that examine factors associated with STI acquisition. These data are needed to draw stronger inferences about risk factors for STI acquisition and potential intervention targets for STI prevention.…”

Section: Introductionmentioning

confidence: 99%

Sexually transmitted infection screening, prevalence and incidence among South African men and transgender women who have sex with men enrolled in a combination HIV prevention cohort study: the Sibanye Methods for Prevention Packages Programme (MP3) project

Jones

Sanchez

Dominguez

et al. 2020

J. Intern. AIDS Soc.

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Introduction: Men who have sex with men (MSM) and transgender women (TGW) experience high incidence and prevalence of sexually transmitted infections (STI), and data are needed to understand risk factors for STIs in these populations. The Sibanye Health Project was conducted in Cape Town and Port Elizabeth, South Africa from 2015 to 2016 to develop and test a package of HIV prevention interventions for MSM and TGW. We describe the incidence, prevalence and symptoms of Chlamydia trachomatis (CT), Neisseria gonorrhea (NG) and syphilis observed during the study. Methods: Participants completed HIV testing at baseline. All participants who were HIV negative were followed prospectively. Additionally, a sample of participants identified as living with HIV at baseline was selected to be followed prospectively so that the prospective cohort was approximately 20% HIV positive; the remaining participants identified as HIV positive at baseline were not followed prospectively. Prospective participants were followed for 12 months and returned for clinic-based STI/HIV testing and assessment of STI symptoms at months 6 and 12. Additional HIV/STI testing visits could be scheduled at participant request. Results: Following consent, a total of 292 participants attended a baseline visit (mean age = 26 years), and 201 were enrolled for the 12-month prospective study. Acceptance of screening for syphilis and urethral NG/CT was near universal, though acceptance of screening for rectal NG/CT was lower (194/292; 66%). Prevalence of urethral CT and NG at baseline was 10% (29/289) and 3% (8/288) respectively; incidence of urethral CT and NG was 12.8/100 person-years (PY) and 7.1/100 PY respectively. Prevalence of rectal CT and NG at baseline was 25% (47/189) and 16% (30/189) respectively; incidence of rectal CT and NG was 33.4/100 PY and 26.8/100 PY respectively. Prevalence of syphilis at baseline was 17% (45/258) and incidence was 8.2/100 PY. 91%, 95% and 97% of diagnosed rectal NG/CT, urethral NG/CT and syphilis infections, respectively, were clinically asymptomatic. Conclusions: Prevalence and incidence of urethral and rectal STIs were high among these South African MSM and TGW, and were similar to rates in other settings in the world. Clinical symptoms from these infections were rare, highlighting limitations of syndromic surveillance and suggesting the need for presumptive testing and/or treatment to address the STI epidemic among MSM/TGW in South Africa.

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“…Wspomniana strategia zapobiegania i kontroli zakażeń STI może zostać wykorzystana w szerszym zakresie, niż określony w samych celach strategii. W hrabstwie Kumbria w Wielkiej Brytanii z powodzeniem wykorzystano metodologię placówek ochrony zdrowia seksualnego, jak i epidemiologię chorób STI do śledzenia kontaktów COVID-19 [42].…”

Section: Epidemiologiaunclassified

Problems of infection with <i>Neisseria gonorrhoeae</i>

Walthoffen¹

2021

Med Og Nauk Zdr.

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Wprowadzenie i cel pracy. Zakażenia przenoszone drogą kontaktów seksualnych są poważnym problemem zdrowia publicznego na całym świecie, wpływają negatywnie na jakość życia oraz powodują poważne choroby, na które każdego dnia zapada ponad milion osób. Pomimo wysokiej zachorowalności na choroby przenoszone drogą kontaktów seksualnych wciąż zaniedbuje się obszary dotyczące programów profilaktycznych walki z tymi chorobami, badań diagnostycznych oraz odpowiedniego leczenia. Celem niniejszej pracy jest przedstawienie problemów związanych z zakażeniami Neisseria gonorrhoeae. Stan dotychczasowej wiedzy. Jedną z częstszych chorób przenoszonych drogą kontaktów seksualnych jest rzeżączka, wywoływana przez bakterię Neisseria gonorrhoeae. Niepowikłane zakażenie gonokokami często objawia się zapaleniem cewki moczowej u mężczyzn i może powodować śluzowo-ropne zapalenie szyjki macicy u kobiet. Zakażenie Neisseria gonorrhoeae ułatwia również przenoszenie ludzkiego wirusa niedoboru odporności (HIV). Rzeżączka jest chorobą uleczalną, jednak patogen, który ją wywołuje, wytwarza wiele mechanizmów oporności na antybiotyki, co może wiązać się z niepowodzeniem leczenia. Zapadalność na rzeżączkę w Polsce w 2018 roku wyniosła 0,5 na 100 tys. osób, przy czym wartość ta jest ponad 50-krotnie niższa dla odpowiednich danych z tego samego okresu dotyczących całej Europy. Podsumowanie. Dane epidemiologiczne mogą wskazywać na niedoszacowanie przypadków rzeżączki w Polsce. Z danych zebranych przez instytucje państwowe wynika, że profilaktyka i diagnostyka chorób przenoszonych przez kontakty seksualne są niedofinansowane.

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Increases in pharyngeal Neisseria gonorrhoeae positivity in men who have sex with men, 2011–2015: observational study

Cited by 5 publications

References 6 publications

Associations between antimicrobial susceptibility/resistance of Neisseria gonorrhoeae isolates in European Union/European Economic Area and patients’ gender, sexual orientation and anatomical site of infection, 2009–2016

Associations between antimicrobial susceptibility/resistance of Neisseria gonorrhoeae isolates in European Union/European Economic Area and patients’ gender, sexual orientation and anatomical site of infection, 2009–2016

Sexually transmitted infection screening, prevalence and incidence among South African men and transgender women who have sex with men enrolled in a combination HIV prevention cohort study: the Sibanye Methods for Prevention Packages Programme (MP3) project

Problems of infection with <i>Neisseria gonorrhoeae</i>

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