Increasing antibiotic resistance of Pseudomonas aeruginosa in urinary tract infection isolates currently recorded in Karachi, Pakistan.

Shah, Dania Aijaz; Wasim, Shehnaz; Abdullah, Farhan Essa

doi:10.12669/pjms.312.6839

Cited by 11 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also observed a high proportion (87%) of doxycycline resistant P. aeruginosa . This is comparable with the 91.07% and 99.6% resistance reported by Javiya et al ( 2008 ) and Shah, Wasim and Abdullah ( 2015 ), respectively. Similarly, a high proportion (100%) of doxycycline resistant P. aeruginosa isolates from dogs with otitis externa was reported by Petrov et al ( 2013 ).…”

Section: Discussionsupporting

confidence: 90%

Antimicrobial resistance patterns of Pseudomonas aeruginosa isolated from canine clinical cases at a veterinary academic hospital in South Africa

Eliasi

Sebola

Oguttu

et al. 2020

Journal of the South African Veterinary Association

View full text Add to dashboard Cite

Although Pseudomonas aeruginosa (P. aeruginosa) can infect both animals and humans, there is a paucity of veterinary studies on antimicrobial resistance of P. aeruginosa in South Africa. Secondary data of canine clinical cases presented at the hospital from January 2007 to December 2013 was used. The following information was recorded: type of sample, the date of sampling and the antimicrobial susceptibility results. Frequencies, proportions and their 95% confidence intervals were calculated for all the categorical variables. In total, 155 P. aeruginosa isolates were identified and included in this study. All the isolates were resistant to at least one antimicrobial (AMR), while 92% were multi-drug resistant (MDR). Most isolates were resistant to lincomycin (98%), penicillin-G (96%), orbifloxacin (90%), trimethoprim-sulfamethoxazole (90%) and doxycycline (87%). A low proportion of isolates was resistant to imipenem (6%), tobramycin (12%), amikacin (16%) and gentamicin (18%). A high proportion of MDR-P. aeruginosa isolates was resistant to amoxycillin-clavulanic acid (99%), tylosin (99%), chloramphenicol (97%) and doxycycline (96%). Few (6%) of MDR-P. aeruginosa isolates were resistant to imipenem. Pseudomonas aeruginosa was associated with infections of various organ systems in this study. All P. aeruginosa isolates of P. aeruginosa exhibited resistance to β-lactams, fluoroquinolones and lincosamides. Clinicians at the hospital in question should consider these findings when treating infections associated with P. aeruginosa.

show abstract

Section: Discussionsupporting

confidence: 90%

Antimicrobial resistance patterns of Pseudomonas aeruginosa isolated from canine clinical cases at a veterinary academic hospital in South Africa

Eliasi

Sebola

Oguttu

et al. 2020

Journal of the South African Veterinary Association

View full text Add to dashboard Cite

show abstract

“…In early 2015, a study from Pakistan has reported even higher rates of resistance for some of the tested antibiotics. Their numbers are higher than ours and on a larger cohort -ceftazidime R = 56.1% and fluoroquinolones R = 50%, except for amikacin R = 25.3% and imipenem R = 10.4% [51].…”

Section: Resultscontrasting

confidence: 76%

Urinary Tract Infections in a Romanian Population: Antimicrobial Resistance of Uropathogens – A Multiregional Study

RUSU¹

2023

FARMACIA

View full text Add to dashboard Cite

Urinary Tract Infections (UTIs) are a serious public health problem determined by a large variety of microorganisms; the leading uropathogen is represented by Escherichia coli, followed by Klebsiella spp., Proteus spp., and Pseudomonas spp. as major Gram-negative bacteria. Enterococcus spp. and Staphylococcus spp. are the most frequent Gram-positive pathogens involved. The presented study aimed to corroborate results from four tertiary hospitals in three different regions of Romania. Analysing 15,907 urine probes, of which 2,842 (17.86%) met the inclusion criteria, for discovering the uropathogen involved in the dynamics of UTIs, desiring to determine the resistance and sensitivity patterns for each pathogen presented, in a comparative approach. Escherichia coli was the leading pathogen 1629 (57.31%), presenting the highest resistance to levofloxacin R = 20.62% and amoxicillin -clavulanic acid R = 18.17%; the second most frequent bacteria were Klebsiella spp. 530 (18.64%), with major resistance to amoxicillin-clavulanic ac. R = 45.66% and ceftazidime R = 29.05%. Enterococcus spp. was the most common Gram-positive strain 340 (11.96%), presenting important resistance to levofloxacin R = 32.35% and penicillin R = 25.29%. Current guidelines recommend adjusting treatment to local data in the management of UTIs; thus, this study involving all three major regions of Romania represents a pivotal point in providing an appropriate recommendation for every health professional. RezumatInfecțiile tractului urinar (ITU) reprezintă o problemă gravă de sănătate publică determinată de o mare varietate de microorganisme; uropatogenul principal este reprezentat de Escherichia coli, urmat de Klebsiella spp., Proteus spp. și Pseudomonas spp. ca bacterii Gram-negative. Enterococcus spp. și Staphylococcus spp. sunt agenții patogeni Gram-pozitivi implicați cel mai frecvent. Studiul prezentat și-a propus să coroboreze rezultatele a patru spitale terțiare din trei regiuni diferite ale României, analizând 15.907 probe urinare dintre care 2.842 (17,86%) au îndeplinit criteriile de includere, pentru determinarea uropatogenului implicat în dinamica ITU și determinarea rezistenței și sensibilității fiecărui agent patogen prezentat, într-o abordare comparativă.

show abstract

“…Ijaz et al reported that among diabetics, 72% urinary samples were positive for Pseudomonas; Bashir et al reported that 1% cases of Pseudomonas were isolated, and Zahra et al 6% cases of Pseudomonas were isolated from non-diabetic urinary samples and none from the diabetic population [9-11]. In non-diabetic Pakistanis, 5% urinary samples were found to be positive for Pseudomonas [15]. In an Indian diabetic sample of 651 culture-positive UTI, the frequency of Pseudomonas was 2.7%; similar to our study, E. coli was also the most commonly isolated pathogen (69%) [16].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Microbiological Profile of Urinary Tract Infections in Diabetic versus Non-Diabetic Individuals

Kumar¹,

Kumar²,

Perswani³

et al. 2019

Cureus

View full text Add to dashboard Cite

Introduction Diabetic patients have a higher tendency of developing all infections, especially infections of the genitourinary tract. In most cases, urinary tract infections (UTI) in diabetic patients are asymptomatic. The aim of this study to was to compare the incidence and clinical and microbiological features of UTI between diabetic and non-diabetic patients. Methods In this prospective, comparative study, the incidence and clinical and microbiological features of UTI were compared between diabetic and non-diabetic patients via consecutive nonprobability sampling technique. For every diabetic patient, one non-diabetic control was included. All patients were screened for UTI through a midstream urinary sample. Their demographic characteristics, clinical profile, and urinary microscopy were compared. Data were entered and analyzed using SPSS version 22.0. Results In the diabetes group, 35/256 (13.67%) patients had culture-positive UTI as compared to 18/250 (7.2%) in the non-diabetic group. Diabetic group had twice the risk of UTI (p = 0.01; odds ratio [OR]: 2.04; confidence interval [CI]: 1.12, 3.71) and female gender in the diabetic group had a risk of almost five times (p = 0.01; OR: 4.93; CI: 1.12, 20.16) that of the non-diabetic group. In the diabetic group, 31.4% patients were asymptomatic as compared to 5.6% in the non-diabetic group (p = 0.03; OR: 7.79; CI: 0.92, 66.18). E. coli was the most commonly identified microorganism in both groups. Pseudomonas aeruginosa was identified in 14% of diabetic cases and none in the non-diabetic. Conclusions UTIs are more frequent among diabetics. Asymptomatic bacteriuria is a more common entity in diabetic patients and does not require any treatment.

show abstract

Increasing antibiotic resistance of Pseudomonas aeruginosa in urinary tract infection isolates currently recorded in Karachi, Pakistan.

Cited by 11 publications

References 12 publications

Antimicrobial resistance patterns of Pseudomonas aeruginosa isolated from canine clinical cases at a veterinary academic hospital in South Africa

Antimicrobial resistance patterns of Pseudomonas aeruginosa isolated from canine clinical cases at a veterinary academic hospital in South Africa

Urinary Tract Infections in a Romanian Population: Antimicrobial Resistance of Uropathogens – A Multiregional Study

Clinical and Microbiological Profile of Urinary Tract Infections in Diabetic versus Non-Diabetic Individuals

Contact Info

Product

Resources

About