Increasing Exogenous Progesterone during Synchronization of Estrus Decreases Endogenous 17β-Estradiol and Increases Conception in Cows1

Wehrman, M. E.; Roberson, Mark S.; Cupp, Andrea S.; Kojima, F. N.; Stumpf, T. T.; Werth, L. A.; Wolfe, Michael W.; Kittok, R. J.; Kinder, J. E.

doi:10.1095/biolreprod49.2.214

Cited by 91 publications

(44 citation statements)

References 25 publications

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“…However, in this study, very large ovulatory follicles were not associated to increased fertility in cows treated with low progesterone. Follicles that grew in a low progesterone environment tended to become persistent follicles and are highly associated with decrease on fertility (Anderson & Day, 1994;Fike et al, 1997;Sanchez et al, 1993;Wehrman et al, 1993). The progesterone concentrations detected on Day 4 (0.53 ± 0.27 ng/mL) confirm that cows were under low progesterone concentrations during the hormonal treatment.…”

Section: Resultsmentioning

confidence: 74%

Effect of the ovulatory follicle diameter and progesterone concentration on the pregnancy rate of fixed-time inseminated lactating beef cows

Pfeifer¹,

Leal

Schneider

et al. 2012

R. Bras. Zootec.

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-The objective of this study was to evaluate the influence of the ovulatory follicle diameter on the reproductive performance of lactating beef cows subjected to low progesterone fixed-time artificial insemination (FTAI) protocols. Ninety-three lactating beef cows (60-80 days postpartum) at random stages of estrous cycle were given a luteolytic dose of prostaglandin F2α (500 μg cloprostenol; PGF) twice, 11 d apart. Ten days after the second PGF treatment, cows were given 1.5 mg of estradiol benzoate im and a progesterone-releasing intravaginal device (Cue-Mate) with a single pod containing 0.78 g progesterone (Day 0). Cows received another luteolytic dose of PGF on Day 0. On Day 8, the Cue-Mate was removed.Fifty-four to 56 hours later, cows received 12.5 mg of porcine LH (pLH) i.m. and were concurrently artificially inseminated.Ultrasound examinations of the ovaries were performed on Days 10 and 17 to evaluate the diameter of ovulatory follicle and corpus luteum, respectively. Cows which presented ovulatory follicle > 19 mm resulted in larger corpus luteum than cows that had ovulatory follicle <15 mm in diameter. However, cows with ovulatory follicle between 13-15 mm had higher pregnancy rate than other categories of ovulatory follicle. Although larger ovulatory follicles result in larger corpus luteum and consequently higher progesterone production, the optimal size of ovulatory follicles (13-15 mm) may result in positive benefits on pregnancy rate for cows subjected to FTAI with low progesterone concentration protocols.

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Section: Resultsmentioning

confidence: 74%

Effect of the ovulatory follicle diameter and progesterone concentration on the pregnancy rate of fixed-time inseminated lactating beef cows

Pfeifer¹,

Leal

Schneider

et al. 2012

R. Bras. Zootec.

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“…Higher blood progesterone concentrations were observed at time of PGF 2α treatment in the Ovsynch+CIDR protocol in postpartum non-cycling beef cows than with the Ovsynch protocol in our previous study [5]. Higher blood progesterone concentrations in the luteal phase prior to estrus reduced uterine secretion of PGF 2α during the late luteal phase after estrus in dairy cows [7] and may then increase conception rates with AI [8,9]. However, no differences have been reported in PGF 2α secretion b e t w e e n t h e C I D R -b a s e d o v u l a t i o nsynchronization and Ovsynch protocols in the following luteal phase in early postpartum noncycling beef cows.…”

mentioning

confidence: 72%

“…All samples were assayed. Estradiol-17β was measured in blood samples collected on Days 7,8,9,13,16,20, 23 and 24.…”

Section: Hormone Assaysmentioning

confidence: 99%

Inhibitory Effects of CIDR-based Ovulation-synchronization Protocols on Uterine PGF2.ALPHA. Secretion at the Following Luteal Phase in Early Postpartum Non-cycling Beef Cows

Sakase

Kawate

Nakagawa

et al. 2006

Journal of Reproduction and Development

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Abstract. We investigated whether CIDR-based ovulation-synchronization protocols inhibit secretion of prostaglandin (PG) F2α from the uterus in the following luteal phase in non-cycling beef cows. Ten early (a month) postpartum non-cycling Japanese Black beef cows were treated with (1) Ovsynch (GnRH analogue on Day 0, PGF2α analogue on Day 7, and GnRH analogue on Day 9; n=3), (2) Ovsynch+CIDR (Ovsynch protocol plus a CIDR for 7 days from Day 0; n=4), or (3) estradiol benzoate (EB) Ovsynch+CIDR (EB on Day 0 in lieu of the first GnRH treatment followed by the Ovsynch+CIDR protocol; n=3). An oxytocin challenge was administered on Day 24 to examine uterine PGF2α secretion. Plasma concentrations of 13,14-dihydro-15-keto-PGF2α were lower at 30-120 min after oxytocin administration in the Ovsynch+CIDR group and 75 min after administration in the EB Ovsynch+CIDR group than in the Ovsynch group (P<0.05). Plasma progesterone concentrations were higher from Days 1 to 7 in the Ovsynch+CIDR group and from Days 1 to 5 in the EB Ovsynch+CIDR group than in the Ovsynch group (P<0.05). The progesterone concentrations were higher on Days 27 and 29 in both CIDR-treated groups than in the Ovsynch group (P<0.05). In conclusion, in noncycling beef cows, CIDR-based ovulation-synchronization protocols inhibit uterine PGF22α secretion in the following luteal phase and prevent premature luteolysis as is seen with the Ovsynch protocol. Key words: Beef cow, CIDR-based ovulation-synchronization protocol, Non-cycling, Ovsynch, Uterine PGF2α secretion (J. Reprod. Dev. 52: [497][498][499][500][501][502] 2006) vulation synchronization, such as Ovsynch or its modified protocols, has been used for timed artificial insemination (timed-AI) in postpartum beef cows [1][2][3][4][5]. In previous studies, we reported that a protocol using an intravaginal controlled internal drug release (CIDR) device in addition to Ovsynch (Ovsynch+CIDR) and another protocol using estradiol benzoate (EB) in lieu of the first g o n a d o t r o p i n -r e l e a s i n g h o r m o n e ( G n R H ) t r e a t m e n t o f t h e O v s y nc h +C I DR p ro t o co l improved the rate of conception following timed-AI in suckled early postpartum beef cows [4,5]. An improved conception rate by the CIDR-based

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“…Several reports have noted that the use of progestin treatment for estrus synchronization for more than 7 d results in reduced fertility Odde et al 1990;Savio et al 1993a;Wehrman et al 1993) due to development and ovulation of a large, persistent dominant follicle (Sirois and Fortune 1990;Savio et al 1993a). The CL arising from these follicles produce normal concentrations of progesterone; therefore, the low fertility is not due to luteal insufficiency (Stock and Fortune 1993).…”

Section: Size Of the Ovulatory Folliclementioning

confidence: 99%

Factors affecting embryo survival and strategies to reduce embryonic mortality in cattle

Bilodeau‐Goeseels¹,

Kastelic²

2003

Can. J. Anim. Sci.

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Bilodeau-Goeseels, S. and Kastelic, J. P. 2003. Factors affecting embryo survival and strategies to reduce embryonic mortality in cattle. Can. J. Anim. Sci. 83: 659-671. Embryonic mortality in cattle is the death of the conceptus before Day 42 of pregnancy. Estimates of embryonic mortality varied greatly, ranging from 10 to 40% in first-service cattle to 65% in repeat-breeder cows. This paper reviews endogenous causes of embryonic mortality, including chromosomal abnormalities, inadequate corpus luteum function and the influence of follicular development on fertility. External causes of embryonic mortality, including heat stress and nutrition, are also reviewed; these factors act by modifying the follicular environment (thereby affecting oocyte quality) or by creating a hostile uterine environment. Strategies to reduce embryonic mortality, including good management practices and supplementation with progesterone or interferon-tau, are discussed. From a practical perspective, improved knowledge of the causes of embryonic mortality and regulation of follicular growth and corpus luteum function should result in the development of improved, cost-effective hormonal regimes that effectively synchronize estrus and ovulation and reduce embryonic mortality, thereby benefiting the cattle industry.Key words: Cattle, reproduction, fertility, embryo development, embryo mortality Bilodeau-Goeseels, S. et Kastelic, J. P. 2003. Les facteurs affectant la survie de l'embryon et les stratégies pour réduire la mortalité embryonnaire chez la vache. Can. J. Anim. Sci. 83: 659-671. Chez la vache, la mortalité embryonnaire se définie comme étant la perte de l'embryon avant le Jour 42 de la gestation. Les estimations de la mortalité embryonnaire varient grandement, allant de 10 à 40 % chez les vaches à fertilité normale jusqu'à 65 % chez les vaches à fertilité réduite. L'article que voiçi examine les causes endogènes de la mortalité embryonnaire incluant les anomalies chromosomales, le fonctionnement inadéquat du corpus luteum ainsi que l'influence du développement folliculaire sur la fertilité. Des causes externes telles que le stress thermique et la nutrition sont aussi passées en revue; ces facteurs agissent en modifiant l'environnement folliculaire ce qui conduit à une diminution de la qualité de l'ovocyte; ou en créant un environnement utérin hostile pour l'embryon. Des stratégies pour réduire la mortalité embryonnaire telles que la bonne gestion et la supplémentation avec de la progestérone ou de l'interféron-tau sont aussi discutées. Du point de vue pratique, l'augmentation des connaissances sur les causes de la mortalité embryonnaire ainsi que sur la régulation de la croissance folliculaire et du fonctionnement du corpus luteum permettra le développement de régimes hormonaux améliorés et économiques produisant des hauts niveaux de synchronization de l'estrus et/ou de l'ovulation et qui réduiront la mortalité embryonnaire, ce don't bénéficieront les industries laitières et bovines. Mots clés:Bovin, reproduction, fertilité, dévelo...

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Increasing Exogenous Progesterone during Synchronization of Estrus Decreases Endogenous 17β-Estradiol and Increases Conception in Cows1

Cited by 91 publications

References 25 publications

Effect of the ovulatory follicle diameter and progesterone concentration on the pregnancy rate of fixed-time inseminated lactating beef cows

Effect of the ovulatory follicle diameter and progesterone concentration on the pregnancy rate of fixed-time inseminated lactating beef cows

Inhibitory Effects of CIDR-based Ovulation-synchronization Protocols on Uterine PGF2.ALPHA. Secretion at the Following Luteal Phase in Early Postpartum Non-cycling Beef Cows

Factors affecting embryo survival and strategies to reduce embryonic mortality in cattle

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