Increasing incidence of primary central nervous system lymphoma but no improvement in survival in Sweden 2000‐2013

Abstract

Objectives: This study aims to characterize the epidemiology of immunocompetent Primary central nervous system lymphoma (PCNSL) diagnosed 2000-2013 in Sweden.Methods: Cases were identified in the population-based Swedish Lymphoma Register.Incidence per 100 000 person-years and 95% confidence intervals (CI) were calculated, and PCNSL-specific survival was estimated using relative survival. Tests for temporal trends were performed using Poisson regression. Population incidence of all brain tumors was retrieved for comparison.Results: With 359 identified PCNSL cases (median age 66 years), overall incidence was 0.26 (95% CI: 0.24-0.29) and the average annual increase 4% (P = .002). The increasing trend was primarily observed among elderly individuals (70+ years). Similarly, an increase in incidence of all brain tumors was noted only among the elderly. There was no significant improvement in relative survival across the study period although, among fit patients (with Eastern Cooperative Oncology Group, EGOC 0), survival plateaued 6 years after diagnosis. Conclusion:The increasing PCNSL incidence in the elderly was consistent with an increasing incidence of brain tumors of any type and may in part be attributable to improved diagnostics and reporting in this group. New treatment options have not yet translated into general survival improvements in a population-based setting, although the presence of long-term survivors among fit patients is encouraging. K E Y W O R D Scentral nervous system neoplasms, epidemiology, incidence, lymphoma, survival

Efficacy of the Nordic and the MSKCC chemotherapy protocols on the overall and progression-free survival in intracranial PCNSL

“…Therefore, this may offer a plausible explanation for why new treatments have not translated into a survival benefit in the group of PCNSL (27). Furthermore, it is likely that the different types of treatment approaches and also the presence of immunocompromised patients played a role as confounding factors in our analysis.…”

“…Despite improvements in chemotherapy protocols, patients with primary CNS lymphomas (PCNSL) still have a dismal prognosis (1,2). Standard chemotherapy protocols which are effective for systemic non-Hodgkin lymphomas, such as CHOP or CHOD have inferior effect in PCNSL, presumably reflecting the difficulty of penetration of the blood-brain barrier (BBB) by most chemotherapeutic agents (3)(4)(5).…”

Primary CNS lymphoma: latest updates and a 10-year monocenter experience

“…The authors showed the increasing PCNSL incidence rate and the possible correlation of this increase with the increasing number of immunosuppressed patients. This appealing issue was confirmed in a recently published paper that reported a current Swedish scenario in which the increasing trend was mostly observed among elderly individuals [ 2 ].…”

Primary pulmonary lymphoma from bronchus-associated lymphoid tissue (clinical observation)

“…онкологии, лучевой диагностики и терапии и радиационной медицины, ГВУЗ «Тернопольский государственный медицинский университет имени И. Я. Горбачевского МЗ Украины». Список літератури [1]…”

“…У другому десятилітті XXI ст. відзначають світову тенденцію до стрімкого підвищення рівня лімфопроліферативних захворювань, серед них усе більшої питомої ваги набувають негоджкінські лімфоми, що перебігають з екстранодальними ураженнями [1,2].…”