Increasing incidence of resistance among shigellae to trimethoprim

Harnett, N; McLeod, Sarah M.; Auyong, Y.; Krishnan, C.

doi:10.1016/0140-6736(91)91694-p

Cited by 11 publications

(10 citation statements)

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“…Entretanto, vários estudos oriundos de diversas localidades do mundo têm demonstrado alta e crescente resistência de espécies de Shigella aos antimicrobianos 2,6,7 . As drogas rotineiramente recomendadas para o tratamento -ampicilina e sulfametoxazol-trimetoprim -apresentam, no momento, altos percentuais de resistência [7][8][9] . Assim, algumas outras drogas têm sido utilizadas para o tratamento da shigelose.…”

Section: Introductionunclassified

“…Assim, algumas outras drogas têm sido utilizadas para o tratamento da shigelose. Um estudo realizado em Bangladesh, em 1985, mostrou que o ácido nalidíxico era efetivo para o tratamento 11 , porém, já tem sido relatada resistência também a essa droga 7,10 . As quinolonas fluoradas e as cefalosporinas de terceira geração (cefixime via oral, por exemplo) também têm sido eficazes 4,13 .…”

Section: Introductionunclassified

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Study of in vitro antimicrobial resistance of positive coprocultures to Shigella sp.

Ba¹,

A²,

Ar³

et al. 1997

J Pediatr (Rio J)

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ResumoIntrodução: A gastroenterite causada pela Shigella sp (shigelose) representa importante causa de morbimortalidade, especialmente em crianças abaixo de 2 anos de idade. Sabe-se que o tratamento antimicrobiano adequado pode melhorar o quadro clíni-co e diminuir a disseminação da doença. Têm sido descritos níveis crescentes de resistência aos antimicrobianos comumente usados para o tratamento, e a sensibilidade da Shigella não foi recentemente avaliada em nosso meio.Objetivo: Avaliar a resistência antimicrobiana das espécies de Shigella em nosso meio.Método: Delineou-se um estudo retrospectivo, utilizando-se 106 coproculturas de pacientes, hospitalizados ou não, que tenham procurado atendimento no HCPA ou no HPV durante o período de 1994 a 1996 com diagnóstico de shigelose firmado por coprocultura e que tenham realizado teste de sensibilidade bacteriana a pelo menos um antibiótico através da técnica de difusão de disco de Kirby-Bauer.Resultados: Das 106 coproculturas estudadas, 35 (33%) foram provenientes do HPV e 71 (67%) do HCPA. Em relação às espécies, 58,5% foram S.flexneri, 39,6% S. sonnei, 0,9% S. dysenteriae e 0,9% S. boydii. Os níveis de resistência aos antibióticos usualmente recomendados para o tratamento foram: ampicilina -57,5%, sulfametoxazol-trimetoprim -75,5% e ácido nalidíxico -7,5%.Conclusões: Esses resultados mostram significativa (p < 0,001) resistência antimicrobiana in vitro à ampicilina e ao sulfametoxazol-trimetoprim e baixa resistência ao ácido nalidíxico entre Shigella sp. Assim, o ácido nalidíxico pode ser considerado uma opção para o tratamento de infecções causadas por organismos resistentes. J. pediatr. (Rio J.). 1997; 73(6):395-400: diarréia bacteriana, shigelose, resistência antimicrobiana. AbstractBackground: The gastroenteritis caused by Shigella sp (shigellosis) represents an important cause of morbimortality, especially in children under two years old. It is well known that the proper antimicrobial therapy can improve clinical state and diminish the disease dissemination. Increasing levels of resistance to drugs commonly used in the treatment of shigellosis have been described, and its sensibility has not been recently evaluated in our setting.Objective: To evaluate the Shigella antimicrobial resistance in our setting.Methods: A retrospective study was conducted using 106 coprocultures of patients, hospitalized or not, who have been assisted at HCPA and at HPV, during the period of 1994 to 1996, with the sensibility test done through the Kirby-Bauer technique of diffusion discs.Results: Out of the 106 coprocultures studied, 35 (33%) came from HPV and 71 (67%), from HCPA. Considering the species, 58.8% were S.flexneri, 39.6%, S.sonnei, 0.9%, S.disenteriae and 0.9%, S. boydii. The resistance levels to usually indicated antibiotics were: ampicillin -57.5%, trimethropim-sulfamethoxazol -75.5%, and nalidixic acid -7.5%.Conclusions: These results show significant (p <0.001) in vitro antimicrobial resistance to ampicillin and trimethoprimsulfamethoxazol and low resistance to nalidi...

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Section: Introductionunclassified

Study of in vitro antimicrobial resistance of positive coprocultures to Shigella sp.

Ba¹,

A²,

Ar³

et al. 1997

J Pediatr (Rio J)

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“…In 1983 and 1984, about 4 to 17% of the isolates were TMP or TMP-SUL resistant (21,50,64), in 1985 7 to 21% were resistant, and later, TMP resistance even increased to 52%, depending on the Shigella sp. (11,60,64,93,168,180). Most of the isolates were multiresistant, with resistance to ampicillin, tetracycline, chloramphenicol, and streptomycin also occurring (49,59).…”

Section: Spread Of Tmp and Sul Resistancementioning

confidence: 99%

Trimethoprim and sulfonamide resistance

Huovinen¹,

Sundström²,

Swedberg³

et al. 1995

Antimicrob Agents Chemother

446

314

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“…Because of our recent observations of the high percentage of antimicrobial resistance among Shigella spp. in Ontario [8,9], the present study was undertaken to determine the incidence of resistance to TMP, cotrimoxazole and other antimicrobial agents among E. coli from urinary tract infections. This study is part of an epidemiologic 474 N. HARNETT longitudinal surveillance of E. coli isolates in Ontario to determine the incidence of antimicrobial resistance and to assess how this compares with that of Shigella spp.…”

Section: Introductionmentioning

confidence: 99%

Transferable high-level trimethoprim resistance among isolates ofEscherichia colifrom urinary tract infections in Ontario, Canada

Harnett¹

1992

Epidemiol. Infect.

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SUMMARYOf 1171 isolates of Escherichia coli isolated from urine samples at the Public Health Laboratory, Toronto, Ontario, Canada, between May 1990 and December 1991, 120 (10-3 %) were resistant to trimethoprim (TMP), cotrimoxazole (TMP/SMX), sulfamethoxazole (SMX) and other antimicrobial agents; 110 of the 120 isolates (91-7 %) were resistant to four or more agents. The majority of Nalidixic acid resistance was present among 22 (18-3 %) of the 120 resistant isolates, however, nalidixic acid resistance was not transferred to E. coli K-12.

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Increasing incidence of resistance among shigellae to trimethoprim

Cited by 11 publications

References 0 publications

Study of in vitro antimicrobial resistance of positive coprocultures to Shigella sp.

Study of in vitro antimicrobial resistance of positive coprocultures to Shigella sp.

Trimethoprim and sulfonamide resistance

Transferable high-level trimethoprim resistance among isolates ofEscherichia colifrom urinary tract infections in Ontario, Canada

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