Increasing incidence of uterine carcinosarcoma: A United States Cancer Statistics study

Liao, Cheng-I; Caesar, Michelle Ann; Lee, Danny; Chan, Ava; Darcy, Kathleen M.; Tian, Chunqiao; Kapp, Daniel S.; Chan, John K.

doi:10.1016/j.gore.2022.100936

Cited by 9 publications

(10 citation statements)

References 9 publications

(14 reference statements)

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“…The results are consistent with the findings of the extracellular and MTT treatment. A series of experiments confirmed the intracellular1 O 2 generation capacity of Fe 50 -Zn-NC 900 under near-infrared light irradiation. At the same time, Fe 50 -Zn-NC 900 (50 μg•mL −1 ) was also treated identically with HeLa cells at a different time.…”

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confidence: 69%

“…Despite ongoing efforts by scientists to improve cancer treatments, the number of people who die from cancer keeps growing each year. 1,2 Cancer treatment includes surgery, radiotherapy, chemotherapy, immunotherapy, phototherapy, and targeted therapy. Among them, phototherapy, especially photothermal therapy (PTT) and photodynamic therapy (PDT), 3,4 have been considered to be prospective cancer therapy methods owing to their minimal invasiveness 5 and high spatiotemporal precision; 6 however, the efficacy of monotherapy is limited by a sophisticated tumor microenvironment, so PTT and PDT are often combined to improve the therapeutic effect on the tumor.…”

Section: ■ Introductionmentioning

confidence: 99%

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Iron-Doped Metal–Zinc-Centered Organic Framework Mesoporous Carbon Derivatives for Single-Wavelength NIR-Activated Photothermal/Photodynamic Synergistic Therapy

Xing

et al. 2023

Langmuir

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Recently, single-wavelength synergetic photothermal/photodynamic (PTT/PDT) therapy is beginning to make its mark in cancer treatment, and the key to it is a photosensitizer. In this work, an iron-doped metal–zinc-centered organic framework mesoporous carbon derivative (denoted as Fe x -Zn-NCT) with a similar porphyrin property was successfully synthesized by a mild, simple, and green aqueous reaction. The effects of different Fe contents and pyrolysis temperatures on the morphology, structure, and PTT/PDT of Fe x -Zn-NCT were investigated. Most importantly, we found that Fe50-Zn-NC900 exhibited excellent PTT/PDT performance under single-wavelength near-infrared (808 nm) light irradiation in a hydrophilic environment. The photothermal conversion efficiency (η) was counted as ∼81.3%, and the singlet oxygen (1O2) quantum yield (Φ) was compared with indocyanine green (ICG) as ∼0.0041. Furthermore, Fe50-Zn-NC900 is provided with a clear ability for generating 1O2 in living tumor cells and inducted massive necrosis/apoptosis of tumor cells with single-wavelength near-infrared laser irradiation. All of these are clear to consider that Fe50-Zn-NC900 displays great potential as an excellent photosensitizer for single-wavelength dual-mode PTT/PDT therapy.

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confidence: 69%

Section: ■ Introductionmentioning

confidence: 99%

Iron-Doped Metal–Zinc-Centered Organic Framework Mesoporous Carbon Derivatives for Single-Wavelength NIR-Activated Photothermal/Photodynamic Synergistic Therapy

Xing

et al. 2023

Langmuir

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“…The incidence in previous literature was less than 5% of primary endometrial cancer [ 1 ] but now exceeds 5%, with a continuously increasing trend, from 1.7% to 5.6% between 1973 and 2013 [ 2 ]. An increasing annual percent change in UCS incidence from 2001–2017 was also observed in the United States [ 3 ]. UCS is notorious for a poorer prognosis than other types of endometrial carcinoma [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 95%

Management and Prognosis of Patients with Recurrent or Persistent/Progressive Uterine Carcinosarcoma

et al. 2022

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Uterine carcinosarcoma (UCS) is a highly aggressive gynecologic malignancy. Recurrent or persistent/progressive disease is usually fatal. We aimed to investigate the management and prognosis of these patients. Clinical records of UCS patients from June 1987 to April 2020 were retrospectively reviewed. The stage was re-assigned with the FIGO 2009 staging system. Univariate and multivariate analyses were used to identify the independent predictors of survival after recurrence (SAR) and cancer-specific survival (CSS). Of the 168 patients, 98 experienced treatment failure. The median time to treatment failure (TTF) was 8.1 months (range: 0.0–89.1). The median follow-up time of censored patients was 32.0 months (range: 16.8–170.7). The 5-year SAR rates of those with recurrent or persistent/progressive disease were 7.6%. On multivariate analysis, salvage therapy mainly using radiotherapy (HR 0.27, 95% CI: 0.10–0.71) or chemotherapy (HR 0.41, 95% CI: 0.24–0.72) or chemoradiotherapy (CRT) (HR 0.33, 95% CI: 0.15–0.75) were associated with improved SAR, whereas disseminated recurrence was associated with significantly worse SAR (HR 3.94, 95% CI: 1.67–9.31, p = 0.002). Salvage therapy using radiotherapy or chemotherapy or CRT significantly improved SAR. Surgery significantly improved CSS but not SAR, adjusting for confounding factors.

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“…It is a public health problem that seriously threatens human life and health [ 1 , 2 , 3 ]. According to research statistics [ 4 , 5 , 6 ], among various diseases, the mortality rate of malignant tumor is the second highest, second only to cardiovascular and cerebrovascular diseases. In the last 20 years, the incidence rate and mortality rate of cancer have been rising at a rate of 20% each year.…”

Section: Introductionmentioning

confidence: 99%

Hot Spots and Trends in the Relationship between Cancer and Obesity: A Systematic Review and Knowledge Graph Analysis

Gao

Yang

Xue

et al. 2023

Life

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Cancer is one of the most difficult medical problems in today’s world. There are many factors that induce cancer in humans, and obesity has become an important factor in inducing cancer. This study systematically and quantitatively describes the development trend, current situation and research hotspot of the relationship between cancer and obesity by using document statistics and knowledge graph visualization technology. Through the visualization technology analysis of knowledge graph in this study, the research hotspot and knowledge base source of the relationship between cancer and obesity in the last 20 years have been ascertained. Obesity-related factors, such as immunity, insulin, adiponectin, adipocytokines, nonalcoholic fatty liver and inflammatory reaction, may affect the occurrence of obesity and increase the risk of cancer. Obesity-related cancers include respiratory cancer, colorectal cancer, hepatocellular cancer, prostate cancer, gastric cancer, etc. Our research provides direction and basis for future research in this field, as well as technical and knowledge basis support for experts and researchers in related medical fields.

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Increasing incidence of uterine carcinosarcoma: A United States Cancer Statistics study

Abstract: Highlights The incidence of uterine carcinosarcoma increased over the past 17 years. Black women in the South ages 70–74 had the highest incidence. Uterine carcinosarcoma increased annually by 2.6% in Hispanic women.

Cited by 9 publications

References 9 publications

Iron-Doped Metal–Zinc-Centered Organic Framework Mesoporous Carbon Derivatives for Single-Wavelength NIR-Activated Photothermal/Photodynamic Synergistic Therapy

Iron-Doped Metal–Zinc-Centered Organic Framework Mesoporous Carbon Derivatives for Single-Wavelength NIR-Activated Photothermal/Photodynamic Synergistic Therapy

Management and Prognosis of Patients with Recurrent or Persistent/Progressive Uterine Carcinosarcoma

Hot Spots and Trends in the Relationship between Cancer and Obesity: A Systematic Review and Knowledge Graph Analysis

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