Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study

Rubatt, Jennifer M.; Darcy, Kathleen M.; Hutson, Alan D.; Bean, Sarah M.; Havrilesky, Laura J.; Grace, L.; Berchuck, Andrew; Secord, Angeles Alvarez

doi:10.1016/j.ygyno.2008.11.030

Cited by 83 publications

(58 citation statements)

References 23 publications

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“…Several reports on a variety of different cancer tissues also showed similar results among CD31-MVD, CD34-MVD and CD105-MVD. 44,46,47 Furthermore, CD105-MVD was reported to be positively correlated with the GS (P < 0.01) and the pT stage (P < 0.001) in clinically organ-confined prostate cancer patients treated by RP. 45 Interestingly, it was also found that CD105-MVD in RP specimens in the case of neo-adjuvant hormonal therapy is a significant predictive factor for biochemical recurrence, whereas CD31-MVD and CD34-MVD are not.…”

Section: Cd105mentioning

confidence: 97%

Reconsideration of the clinical and histopathological significance of angiogenesis in prostate cancer: Usefulness and limitations of microvessel density measurement

Miyata

Sakai

2015

Int J of Urology

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Angiogenesis plays important roles in tumor growth and cancer cell dissemination in almost all cancers. In prostate cancer, there is general agreement that increased angiogenesis is an important factor in determining tumor development and prognosis in these patients. Microvessel density is recognized as a useful marker for evaluating the angiogenic status of cancer tissues. Many investigators have reported that microvessel density is significantly associated with pathological features and outcomes in prostate cancer patients; however, some researchers have expressed opposing opinions. As the reason for such discrepancy, previous reports have suggested differences in the methodologies of measuring microvessel density in cancer tissues. In the present review, we focus on the variation in such methods, including the selected area and the method used for (semi)quantification. In particular, we discuss the relationship between malignancy potential, tumor progression, and survival and differences in the antibodies used for detection of endothelial cells in detail. We briefly compare the pathological significance and prognostic roles of microvessel density measured using von Willebrand factor, CD31, CD34, and CD105. Based on these analyses, the advantages and limitations of microvessel density measurements in prostate cancer tissues are clarified. Improved "real" and "specific" markers of cancerrelated angiogenesis are necessary for better predictions of prognoses and for discussion of treatment strategies for patients with prostate cancer. However, establishment of a satisfactory cancer-related endothelial marker could take a long time. Therefore, knowledge regarding the pathological significance of microvessel densitybased on understanding of the advantages and limitations of microvessel density determination methods -is important.

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Section: Cd105mentioning

confidence: 97%

Reconsideration of the clinical and histopathological significance of angiogenesis in prostate cancer: Usefulness and limitations of microvessel density measurement

Miyata

Sakai

2015

Int J of Urology

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“…Microvessel density (MVD) is the gold standard to evaluate angiogenesis in solid cancers (Goodheart et al 2005), and high MVD was recently shown to predict lower progression-free survival in women with advanced epithelial ovarian cancer (Rubatt et al 2009). The vascular endothelial growth factor (VEGF) and the VEGF receptor (VEGFR) families are key regulators of angiogenesis, and the expression of VEGF is frequently upregulated in tumor cells via a number of environmental cues (Hicklin and Ellis 2005).…”

Section: Introductionmentioning

confidence: 99%

Expression of tumor suppressor gene ING4 in ovarian carcinoma is correlated with microvessel density

Liu

Wang

et al. 2012

J Cancer Res Clin Oncol

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“…Several neoplasm have been investigated for Endoglin CD 105 expression including colorectal cancer [13]; Breast Carcinomas [14]; clear cell renal cell carcinoma [15]; endometrial carcinoma [16]; esophageal adenocarcinoma [17]; gastric carcinoma [18]; laryngeal squamous cell carcinoma [19]; advanced Epithelial Ovarian Cancer [20]; Pancreatic carcinoma [21].…”

Section: Discussionmentioning

confidence: 99%

Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma

Basnaker¹,

Bnvs²

2014

JCDR

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Objective: To assess the expression of Endoglin and Microvessel Density in clinically normal oral mucosa of non-tobacco and tobacco habituated patients & also histopathologically confirmed cases of oral squamous cell carcinoma (OSCC) patients. Materials and Methods:Twenty cases of clinically normal oral mucosa with tobacco habituation in the form of chewing or smoking, 20 histopathologically confirmed cases of OSCC and twelve normal healthy oral mucosal cases without tobacco habituation in any form, served as control group, were immunohistochemically analysed for expression of Endoglin (CD-105). Chi-square test is used to determine statistical analysis and significance. Result & Conclusion:The finding of 65% of Endoglin CD -105 positivity and microvessel density (MVD) in the mucosal specimens of tobacco users may be attributed as neoangiogenesis or angiogenic squamous dysplasia like phenomenon occurring as important pathological biomarker preceding oral cancer development, and may therefore be useful as a predictive marker of malignancy.

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Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study

Cited by 83 publications

References 23 publications

Reconsideration of the clinical and histopathological significance of angiogenesis in prostate cancer: Usefulness and limitations of microvessel density measurement

Reconsideration of the clinical and histopathological significance of angiogenesis in prostate cancer: Usefulness and limitations of microvessel density measurement

Expression of tumor suppressor gene ING4 in ovarian carcinoma is correlated with microvessel density

Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma

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