In this study, a new type of rotary dryer filled with inert alumina ceramic bead (ACB) fillers was introduced to treat the industrial wastewater, e.g., the high-salt wastewater and landfill leachate. Numerical simulations based on the Discrete Element Method (DEM) on the motion trajectory of ACB fillers in the rotary dryer were conducted, and the parameters of flight structure, rotational speed, and filling degree on the dynamic behavior of ACB fillers were optimized. Under various rotational speeds and filling degrees, the experimental results fit the numerical-simulated results very well. The optimized flight configuration was the straight flights with a length of 65 mm, and the optimized rotational speed and filling degree were 35 rpm and 15%, respectively. Under the optimized condition, both the response variables, the mass of particles in the airborne phase (MAP) and the percentage of occupied area in the airborne region (OAR), have the optimal values, in which the dryer will have a better drying performance. Besides, the lower-right area of the drum is empty which is convenient for the installation of the inlet pipe. The drying experiments of industrial wastewaters were also studied using this ACB filled rotary drum dryer under the optimized conditions. Under the optimal operational conditions, the evaporation capacities of the high-salt wastewater and landfill leachate could reach as high as 49.7 kg/h and 90 kg/h, respectively. This study highlights the integration of evaporation and drying processes of this novel ACB filled rotary dryer and provides an efficient and zero-liquid-emission strategy for the thermal treatment of industrial wastewater.