Individual differences in intracortical inhibition predict motor-inhibitory performance

He, Jason; Fuelscher, Ian; Coxon, James P.; Chowdhury, Nahian S.; Teo, Wei Peng; Barhoun, Pamela; Enticott, Peter G.; Hyde, Christian

doi:10.1007/s00221-019-05622-y

Cited by 21 publications

(22 citation statements)

References 49 publications

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“…Thus, intervention attempts designed to improve local and/or long-distance connectivity strength with the right insula may strengthen inhibition in SSD. SICI is important as it was associated with other inhibitory tasks such as Go-No-Go and Stop-Signal task performance in healthy subjects ( He et al, 2019 ), and processing speed performance in SSD ( Du et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia

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Adhikari

et al. 2021

NeuroImage: Clinical

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Highlights Exploration of neural basis of the short-interval intracortical inhibition (SICI) marker using paired-pulse TMS in individuals with schizophrenia. Use of a combination of resting fMRI methods (ReHo and rsFC) to explore connectivity patterns associated with SICI. Local insula connectivity was associated with SICI in schizophrenia. Interhemispheric insula-sensorimotor connectivity mediates association between SICI and local insula connectivity.

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Section: Discussionmentioning

confidence: 99%

Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia

Hare

Adhikari

et al. 2021

NeuroImage: Clinical

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“…In general, the relationship between ongoing corticospinal brain activity and behavioral motor functioning has been extensively investigated (Duque et al 2017). Recently, quite a few studies (Chowdhury et al 2018, 2019a, 2019b, 2020a, 2020b; He et al 2019; Hermans et al 2019) have investigated the relationship between offline TMS-derived GABAergic inhibitory biomarkers (resting-state SICI, LICI) and behavioral motor-inhibitory efficiency. In particular, in their study Chowdhury and Colleagues (2018) showed for the first time a negative correlation between individual GABA A ergic intracortical motor inhibition (measured via SICI’s amplitude) and SSRT’s length, indicating that subjects with stronger resting state SICI tend to be faster at inhibiting their responses, and so better at action stopping.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, it is still unclear whether individual differences in these neurophysiological markers of intracortical inhibition might be related to actual behavioral individual differences in inhibitory control efficiency (Chowdhury et al 2017; He et al 2019). Recently quite a few studies (Chowdhury et al 2018, 2019a, 2019b, 2020a, 2020b; He et al 2019; Hermans et al 2019) have investigated whether and to what extent individual levels of resting-state SICI and LICI measured offline might reflect individual differences in the efficiency of the inhibitory processes, indexed by the length of the SSRT. Taken together, these studies support the hypothesis that trait-like interindividual differences the neurophysiological markers of intracortical inhibition (and SICI in particular) can predict individual’s actual behavioral motor inhibition capacities (Chowdhury et al 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Overall, the ongoing modulation of corticospinal excitability and intracortical inhibition within M1 appears to be critical to the successful restraint and cancellation of actions. Nevertheless, it is still unclear whether individual differences in these neurophysiological markers of intracortical inhibition might be related to actual behavioral individual differences in inhibitory control efficiency 12,33 . Recently quite a few studies 8–13,33,34 have investigated whether and to what extent individual levels of resting-state SICI and LICI measured offline might reflect individual differences in the efficiency of the inhibitory processes, indexed by the length of the SSRT.…”

Section: Introductionmentioning

confidence: 99%

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Cortical Silent Period reflects individual differences in action stopping performance

Paci

Cosmo

Ferri

et al. 2020

Preprint

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Inhibitory control is the ability to suppress unwanted actions. At the behavioral level, this ability can be measured via the Stop-Signal Task (stop-signal reaction time, SSRT). At the neural level, Transcranial Magnetic Stimulation provides electrophysiological measures of motor inhibition within the primary motor cortex (M1), such as the Cortical Silent period (CSP), a biomarker of proactive intracortical inhibition mainly mediated by GABAB receptors. Individual differences in this biomarker might contribute to behavioral differences in inhibitory control. Hence, we explored the relationship between intracortical inhibition and behavioral inhibition. Levels of intracortical inhibition were determined by measuring the length of individuals’ CSP, while inhibitory capacities were assessed by the SSRT. We found a significant positive correlation between CSP and SSRT, namely that individuals with greater GABABergic-mediated proactive inhibition seems to perform worse in inhibiting behavioral responses. These results suggest that individual differences in intracortical inhibition are mirrored by differences in motor-inhibitory ability.

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“…The ARI task was originally developed by Slater-Hammel in 1960 17 and was later implemented by Stinear & Byblow to assess the neurophysiology of Focal Hand Dystonia 5 . ARI tasks have become increasingly popular, especially in studies where it is used concomitantly with transcranial magnetic stimulation (TMS) [19][20][21][22][23][24][25] . Unlike choice-reaction stop-signal tasks, ARI tasks do not require participants to make choice responses on go trials, but instead require them to make an anticipated response in order to stop a moving indicator (typically a vertically filling bar) at a predefined stationary target (See Fig.…”

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confidence: 99%

OSARI, an Open-Source Anticipated Response Inhibition task

He¹,

Hirst²,

Puri³

et al. 2021

Preprint

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The stop-signal paradigm has become ubiquitous in investigations of inhibitory control. Tasks inspired by the paradigm, referred to as stop-signal tasks, require participants to make responses on go trials and to inhibit those responses when presented with a stop-signal on stop trials. Currently, the most popular version of the stop-signal task is the ‘choice-reaction’ variant, where participants make choice responses, but must inhibit those responses when presented with a stop-signal. An alternative to the choice-reaction variant of the stop-signal task is the ‘anticipated response inhibition’ task. In anticipated-response inhibition tasks, participants are required to make a planned response that coincides with a predictably timed event (such as lifting a finger from a computer key to stop a filling bar at a predefined target). Anticipated-response inhibition tasks have some advantages over the more traditional choice-reaction stop-signal tasks and are becoming increasingly popular. However, currently, there are no openly available versions of the anticipated response inhibition task, limiting potential uptake. Here, we present an open-source, free, and ready-to-use version of the anticipated-response inhibition task, which we refer to as the OSARI (the Open-Source Anticipated Response Inhibition) task.

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Individual differences in intracortical inhibition predict motor-inhibitory performance

Cited by 21 publications

References 49 publications

Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia

Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia

Cortical Silent Period reflects individual differences in action stopping performance

OSARI, an Open-Source Anticipated Response Inhibition task

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