This paper investigates the gender differences in the occupants' perception on various aspects of indoor environmental quality (IEQ) by two lines of inquiry; Firstly, a comprehensive literature survey spanning the research areas of indoor air quality (IAQ), sick building syndrome (SBS), thermal comfort, lighting, and acoustics was conducted. Secondly, statistical analyses were performed on a large, predominantly North American Post-Occupancy Evaluation (POE) database (N=38,257).Statistical analyses indicated that female occupants' satisfaction levels were consistently lower than male occupants for all fifteen IEQ factors (including thermal comfort, air quality, lighting, acoustics, office layout & furnishings, and cleanliness & maintenance) addressed in POE questionnaire, and the differences were statistically significant. Logistic regression analysis identified a significant association between female gender and dissatisfaction with individual IEQ factors. Those gender differences quantified by odds ratios (OR) were most pronounced for dissatisfaction with thermal environment, IAQ, and workspace cleanliness. The analyses produced consistent results, even after potential confounding factors such as age and work characteristics were controlled.