Individual Differences in Vulnerability to Sleep Loss in the Work Environment

Dongen, Hans P A Van; Belenky, Gregory

doi:10.2486/indhealth.47.518

Cited by 98 publications

(61 citation statements)

References 46 publications

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“…In an investigation of the PVT, frontal and parietal activations were required to assure a good task performance after sleep deprivation versus baseline (33). From cognitive performance under sleepdeprivation conditions, it is known that the degree of impairment varies highly among individuals (34). Differences in caffeine effects have been linked to sleep-loss-induced performance impairments (35) and to genetic variants of the adenosinergic system (36,37).…”

Section: Discussionmentioning

confidence: 99%

Recovery sleep after extended wakefulness restores elevated A ₁ adenosine receptor availability in the human brain

Elmenhorst

Hennecke

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Adenosine and functional A 1 adenosine receptor (A 1 AR) availability are supposed to mediate sleep-wake regulation and cognitive performance. We hypothesized that cerebral A 1 AR availability after an extended wake period decreases to a well-rested state after recovery sleep. [ 18 F]CPFPX positron emission tomography was used to quantify A 1 AR availability in 15 healthy male adults after 52 h of sleep deprivation and following 14 h of recovery sleep. Data were additionally compared with A 1 AR values after 8 h of baseline sleep from an earlier dataset. Polysomnography, cognitive performance, and sleepiness were monitored. Recovery from sleep deprivation was associated with a decrease in A 1 AR availability in several brain regions, ranging from 11% (insula) to 14% (striatum). A 1 AR availabilities after recovery did not differ from baseline sleep in the control group. The degree of performance impairment, sleepiness, and homeostatic sleep-pressure response to sleep deprivation correlated negatively with the decrease in A 1 AR availability. Sleep deprivation resulted in a higher A 1 AR availability in the human brain. The increase that was observed after 52 h of wakefulness was restored to control levels during a 14-h recovery sleep episode. Individuals with a large increase in A 1 AR availability were more resilient to sleep-loss effects than those with a subtle increase. This pattern implies that differences in endogenous adenosine and A 1 AR availability might be causal for individual responses to sleep loss.S leep loss is known to impair almost every aspect of cognition, such as learning (1), long-term memory consolidation (2), attention and psychomotor vigilance (PVT) (3), and executive functions (4), including decision making (5) and emotional control (6). Sleep deprivation further typically alters the frequency distribution of the waking electroencephalogram (EEG) as an indicator of alertness corresponding to cognitive performance (7). However, large interindividual differences exist in the degree of cognitive performance decline during sleep deprivation (3). In a trait-like process, some individuals keep high-level performance during sustained wakefulness, whereas others suffer from severe performance loss (3). The neuro-molecular mechanisms in the brain responsible for these different vulnerabilities are still largely unknown. Caffeine, commonly consumed for fighting fatigue, promotes wakefulness via adenosine receptor antagonism. It seems likely that the adenosinergic system is a neurochemical link between performance and sleep (8). Adenosine is contributing to the homeostatic process of sleep-wake regulation (for review, see refs. 9-12). As has been shown in cats and rats, extracellular adenosine concentration fluctuates rhythmically in many brain regions, such as the basal forebrain, increasing during wakefulness and decreasing during sleep: it thereby induces sleep after wake extension and is in turn restored to baseline levels after recovery sleep (13). For additional information on adenosine, see...

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Section: Discussionmentioning

confidence: 99%

Recovery sleep after extended wakefulness restores elevated A ₁ adenosine receptor availability in the human brain

Elmenhorst

Hennecke

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…Tal situação pode não ser suportada por muitos indivíduos e aumentam o risco de acometimento de inú-meras patologias. 3 Por esta razão, os estudos sobre a temática se reportam aos termos tolerância ou resiliência 4 ao descreverem aqueles possíveis fatores, de ordem social e, especialmente de ordem individual, que estariam associados com menores consequências do trabalho em turnos para a saúde. Esta discussão aponta para dúvidas a respeito da real possibilidade de considerar que o ser humano possa se adaptar de forma plena a este tipo de trabalho.…”

Section: Variáveis Investigadasunclassified

Absenteísmo na Indústria está Associado com o Trabalho em Turnos e com Problemas no Sono

et al. 2017

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RESUMOIntrodução: Cada vez mais as indústrias mantêm seu volume de produção durante as 24h horas do dia. Esta reorganização temporal traz repercussões importantes para a saúde do trabalhador. O objetivo deste estudo foi analisar os fatores associados ao absenteísmo em trabalhadores de diferentes turnos de uma indústria de grande porte do sul do Brasil. Método: A amostra foi composta por 885 profissionais com média de idade de 31,1(8,5) anos de uma indústria do setor de telecomunicação. A variável dependente foi avaliada por meio de faltas ao trabalho nos últimos 12 meses por motivos de saúde. Resultados: A frequência de absenteísmo foi de 16,6%. Os fatores associados ao desfecho foram a idade avançada (OR=2,16; IC95%= 1,27-3,67), o trabalho em turnos extremos, primeiro turno (OR=1,91; IC95%= 1,08-3,36) e terceiro turno (OR=2,06; IC95%= 1,01-4,25), percepção elevada de estresse (OR=1,74; IC95%= 1,07 -2,82) e os distúrbios do sono (OR=2,03; IC95%= 1,07-3,76). Não foram identificadas associações entre absenteísmo e fatores de estilo de vida como prática de atividade física e consumo de álcool e tabaco. Conclusão: Trabalhadores com distúrbios de sono e que exercem suas funções em turnos extremos (manhã ou noite) possuíram mais chance de faltar ao trabalho por questões de saúde. ABSTRACTIntroduction: Increasingly the industry maintains its production volume during the 24 hours of the day. This time reorganization has important implications for workers' health The aim of this study was to analyze factors associated with absenteeism among workers in different shifts of a large industry in southern Brazil. Methods: The sample consisted of 885 professionals with an average age of 31.1 (8.5) years of the telecommunication sector industry. The dependent variable was assessed by absence from work in the last 12 months for health reasons. Results: The absenteeism rate was 16.6%. Factors associated with outcome were advanced age (OR = 2.16, 95% CI 1.27 to 3.67), work in extreme shifts, first round (OR = 1.91, 95% CI 1.08 3.36) and third round (OR = 2.06, 95% CI 1.01 to 4.25), high perceived stress (OR = 1.74, 95% CI 1.07 to 2.82) and sleep disorders (OR = 2.03, 95% CI 1.07 to 3.76). No associations were found between absenteeism and lifestyle factors such as physical activity and consumption of alcohol and tobacco. Conclusion: Workers with sleep disorders and perform their duties in extreme shifts (morning or night) possessed more likely to miss work for health reasons.

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“…Vulnerability to sleep loss, circadian phase position (chronotype), and flexibility of sleep timing (natural ability to sleep and work at unusual times of day) have been suggested as predictors (Iskra-Golec, 1993;Kerkhof, 1985;Lammers-van der Holst et al, 2006;Van Dongen, 2006;Van Dongen & Belenky, 2009).…”

Section: Introductionmentioning

confidence: 99%

Inter-individual differences in sleep response to shift work in novice police officers – A prospective study

Holst

Dongen

Drosopoulos

et al. 2016

Chronobiology International

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The aim of this longitudinal study on novice police officers was to investigate inter-individual differences in sleep response to shift work, and to identify potential baseline predictors thereof. A total of 42 subjects were assessed at baseline, prior to commencing shift work. They were re-assessed during three follow-up sessions within the first 2 years of shift work exposure after approximately 4, 12, and 20 months of rotating shift work. Wrist actigraphy and sleep logs were used to investigate nocturnal sleep at baseline and daytime sleep after night shifts during the follow-up sessions. Actigraphically estimated total sleep time and subjective sleep quality were analyzed as outcome variables, using mixed-effects analysis of variance. Systematic inter-individual differences were observed in the overall response of these outcome variables to shift work. In this sample, flexibility of sleeping habits and gender were found to be predictors of daytime total sleep time in the first 2 years of shift work exposure. Flexibility of sleeping habits and subjective quality of nighttime sleep prior to shift work were found to be predictors of subjective quality of daytime sleep. These results suggest that it may be possible to detect and even predict sleep deficiencies in response to shift work early on, which could be a basis for the development of individualized interventions to improve shift work tolerance.

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Individual Differences in Vulnerability to Sleep Loss in the Work Environment

Cited by 98 publications

References 46 publications

Recovery sleep after extended wakefulness restores elevated A ₁ adenosine receptor availability in the human brain

Recovery sleep after extended wakefulness restores elevated A ₁ adenosine receptor availability in the human brain

Absenteísmo na Indústria está Associado com o Trabalho em Turnos e com Problemas no Sono

Inter-individual differences in sleep response to shift work in novice police officers – A prospective study

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Individual Differences in Vulnerability to Sleep Loss in the Work Environment

Cited by 98 publications

References 46 publications

Recovery sleep after extended wakefulness restores elevated A 1 adenosine receptor availability in the human brain

Recovery sleep after extended wakefulness restores elevated A 1 adenosine receptor availability in the human brain

Absenteísmo na Indústria está Associado com o Trabalho em Turnos e com Problemas no Sono

Inter-individual differences in sleep response to shift work in novice police officers – A prospective study

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Recovery sleep after extended wakefulness restores elevated A ₁ adenosine receptor availability in the human brain

Recovery sleep after extended wakefulness restores elevated A ₁ adenosine receptor availability in the human brain