Indocyanine green elimination but not bilirubin indicates improvement of graft function during MARS therapy

Abstract

Measurement of indocyanine green plasma disappearance rate (PDR(ICG)) has been suggested as a meaningful liver function parameter. However, there are only very limited data concerning its value in the monitoring of graft dysfunction (GDF) and primary non-function (PNF) especially during molecular absorbent recirculating system (MARS) therapy. This study was therefore performed to evaluate the diagnostic accuracy to detect and monitor GDF with the measurement of the PDR(ICG) in direct comparison with conventional markers like bilirubin and prothrombin time (PT). Of the 19 liver recipients, four patients with GDF and two patients with PNF were treated with 38 MARS cycles. Only PDR(ICG) did reliably indicate liver function between patients with GDF/PNF and patients with sufficient graft function who served as controls. Moreover, receiver operating characteristic analysis showed the highest areas under the curve (AUC) for PDR(ICG) (AUC(PDRICG max): 0.840, AUC(PDRICG max): 0.822), followed by bilirubin (AUC(bilirubin): 0.528) and PT (AUC(PT): 0.546). In contrast to the decrease of the serum bilirubin concentration due to MARS, a noticeable improvement of PDR(ICG) was evident only in patients with GDF. Patients with acute fulminant failure and PNF had significantly lower PDR(ICG) values, which did not improve even during continuous MARS treatments. Conclusively, monitoring of PDR(ICG) is superior to bilirubin and PT measurements to determine the graft function especially in patients with PNF and GDF undergoing MARS therapy.

Evaluation of indocyanine green clearance and model for end‐stage liver disease for estimation of short‐term prognosis in decompensated cirrhosis

“…In this study, PDR values <16%/min were associated with a sharp increase in mortality to approximately 50%. More recently, ICG PDR was found to be superior to bilirubin or INR as an indicator of post‐operative liver failure after liver resection (25) or graft dysfunction following liver transplantation (26).…”

Current and Potential Applications for Indocyanine Green in Liver Transplantation

“…40 A number of other studies have demonstrated an association between EAD, primary nonfunction, and ICG clearance, albeit using different methods of measurement (KICG, PDR, R15), different timings of measurement (60 min to postoperative day 3), and different cutoff values (PDR <10% to <18%) (Table 1). 23,39,[49][50][51][52] Clearly, a standardized method would be useful for comparison between studies.…”