Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging

Oxygen and indocyanine green loaded phase-transition nanoparticle-mediated photo-sonodynamic cytotoxic effects on rheumatoid arthritis fibroblast-like synoviocytes

“…[29][30][31][32] Several studies have demonstrated that ICG-loaded PLGA nanoparticles (NPs) could improve the stability of ICG and act as an efficient carrier to deliver ICG to the lesion area to perform the function of therapy or imaging. [33][34][35][36] Furthermore, it has been demonstrated that liquid perfluorocarbon compounds (PFC) act as a good oxygen carrier 37 and are widely used in ultrasound imaging, and PLGA NPs entrapped with PFC droplets have been reported in several studies. [38][39][40] So far, there is no report about the establishment and application of PLGA NPs delivering ICG and oxygen simultaneously.…”

Effects of nanoencapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs

“…52,53 While these studies demonstrated the efficacy of targeted fluorescence imaging of tumors using functionalized ICGcontaining constructs, they did not isolate the effects of ICG encapsulation -and the additional PEGylation of the constructs in the absence of targeting moieties such as folic acid -in modulating the biodistribution of encapsulated ICG in a non-diseased mammalian system.…”

“…53 Although the investigators reported the utility of these structures in targeted fluorescent imaging of tumor-bearing mice, the lipid 2 kDa PEG-folic acid assembly was not covalently attached to the inner PLGA construct. Further, since PEG was simply a linker between the lipid and the folic acid, its role in suppressing nonspecific interactions is not clear.…”

Plaque-hyaluronidase-responsive high-density-lipoprotein-mimetic nanoparticles for multistage intimal-macrophage-targeted drug delivery and enhanced anti-atherosclerotic therapy

“…32 Briefly, a mixture of lipid (DPPE:PC:OL mole ratio, 2:1:0.35) and 1.2 mg/mL of TPGS was dissolved in methanol/ chloroform (1:1, v/v) and dried overnight in an egg-plant flask to form a dry film. Phosphate-buffered saline (PBS) buffer (0.01 M, pH 7.4) was then added to hydrate the dried film, and the obtained hybrid suspension was vortexed thoroughly followed by ultrasonication in an ice bath to obtain the vesicle solution.…”