Indocyanine Green-Loaded Gold Nanoflowers@Two Layers of Silica Nanocomposites for Photothermal and Photodynamic Therapy of Oral Carcinoma

Progress of Nanomaterials-Based Photothermal Therapy for Oral Squamous Cell Carcinoma

“…In other work, Song et al successfully constructed ICG-loaded gold nanocomposite for the synergistic effect of PDT and PTT in oral cancer. The nanocomposite was formed by gold nanoflower core and double-layer silica shell (AuNFs@SiO 2 @mSiO 2 -ICG) [ 107 ]. Ren et al prepared a multifunctional spherical nanoparticle (DOC-SINPs) containing docetaxel, stromal cell-derived factor 1 (SDF-1), ICG, and perfluorohexane (PFH).…”

Recent advances in nanosized metal organic frameworks for drug delivery and tumor therapy

“…The singlet oxygen combines with biological macromolecules in cells and breaks the structure of DNA, thus resulting in apoptosis. These photosensitizers include methylene blue, 135 black phosphorus, 136 ICG 137 and cyanine dye. 138 These photosensitizers are integrated into nano-MOFs is the same manner as photosensitizers in PTT.…”

ανβ3 integrin-targeted ICG-derived probes for imaging-guided surgery and photothermal therapy of oral cancer

“…24–26 ICG-loaded gold nanoparticles have been applied for photothermal therapy (PTT) of oral tumors. 27 Nevertheless, their complicated fabrication, poor tumor-targeting capability, and potential biological toxicity largely impede their extensive application in clinics. Therefore, developing novel ICG-derived tumor-targeting NIR fluorescent probes with excellent imaging characteristics and therapeutic functions is highly demanded for precise diagnosis and treatment of oral tumors.…”