Indocyanine green plasma disappearance rate as dynamic liver function test in critically ill patients

B, Halle; Poulsen, Thomas; Pedersen, Helene Pape

doi:10.1111/aas.12406

Cited by 67 publications

(69 citation statements)

References 27 publications

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“…Early (and perhaps self limiting) phases of ischemic injuries have a moderate impact on the phase Ⅱ processes, defined as "relatively robust" [7] . Among the causes of hyperbilirubinemia (generally speaking due to an increased production or a reduced clearance) relevant are hemolysis, damage of cellular components and reduced intrahepatic bile excretion.…”

Section: Static Assessment Of Liver Functionmentioning

confidence: 99%

“…Worldwide, ICG clearance is the most common and easy -to -use test for the perioperative dynamic assessment of liver function in case of major liver surgery (resective surgery and liver transplantation) and in the intensive care unit (ICU) [2,[6][7][8] . ICG is an inert, water-soluble, fluorescent tricarbocyanine, with a protein binding close to 95% (mainly, alpha1-and beta-lipoproteins and albumin).…”

Section: Assessment Of Liver Functionmentioning

confidence: 99%

“…ln modern critical care medicine, extensive and accurate liver function assessment has a relevant place while caring for high risk medical patients or candidates to major liver surgery: At the moment, static and dynamic tests are available [1][2][3][4][5][6][7] . Static tests, since long included in scores able to quantify acute and chronic (CHILD PUGH, MELD) hepatic dysfunction, assess separately the different functions of the liver and describe the size of the hepatic injury [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

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Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Gasperi

Mazza

Prosperi

2016

WJH

150

124

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Indocyanine green (ICG) kinetics (PDR/R15) used to quantitatively assess hepatic function in the perioperative period of major resective surgery and liver transplantation have been the object of an extensive, updated and critical review. New, non invasive bedside monitors (pulse dye densitometry technology) make this opportunity widely available in clinical practice. After having reviewed basic concepts of hepatic clearance, we analysed the most common indications ICG kinetic parameters have nowadays in clinical practice, focusing in particular on the diagnostic and prognostic role of PDR and R15 in the perioperative period of major liver surgery and liver transplantation. As recently pointed out, even if of extreme interest, ICG clearance parameters have still some limitations, to be considered when using these tests. Core tip: Non invasive monitors for indocyanine green (ICG) clearance (PDR and R15) are now available for a rapid assessment of liver function both in the intensive care unit and in major liver surgery. After having reviewed the basic concepts of hepatic clearance, we have analysed the most common indications of ICG kinetic parameters in clinical practice, focusing on the diagnostic and prognostic role of PDR and R15 in the perioperative period of major resective liver surgery and liver transplantation. Since ICG parameters have still some limitations, we will underline the conditions (mainly hyperbilirubinemia and severe peripheral hypoperfusion) able to alter the reliability of these tests.De Gasperi A, Mazza E, Prosperi M. Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery? World

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Section: Static Assessment Of Liver Functionmentioning

confidence: 99%

Section: Assessment Of Liver Functionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Gasperi

Mazza

Prosperi

2016

WJH

150

124

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“…Initially used in the detection of macular degeneration8, the technique of angiography using indocyanine green (ICG) has been used to identify sentinel lymph nodes9, to determine the extent of oncological resections10 and to study hepatic function11. Recent studies have also demonstrated its usefulness in evaluating the vascular blood flow of intestinal anastomoses12.…”

Section: Introductionmentioning

confidence: 99%

Parathyroid gland angiography with indocyanine green fluorescence to predict parathyroid function after thyroid surgery

Fortuny

Belfontali

Sadowski

et al. 2016

British Journal of Surgery

151

130

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BackgroundPostoperative hypoparathyroidism remains the most common complication following thyroidectomy. The aim of this pilot study was to evaluate the use of intraoperative parathyroid gland angiography in predicting normal parathyroid gland function after thyroid surgery.MethodsAngiography with the fluorescent dye indocyanine green (ICG) was performed in patients undergoing total thyroidectomy, to visualize vascularization of identified parathyroid glands.ResultsSome 36 patients underwent ICG angiography during thyroidectomy. All patients received standard calcium and vitamin D supplementation. At least one well vascularized parathyroid gland was demonstrated by ICG angiography in 30 patients. All 30 patients had parathyroid hormone (PTH) levels in the normal range on postoperative day (POD) 1 and 10, and only one patient exhibited asymptomatic hypocalcaemia on POD 1. Mean(s.d.) PTH and calcium levels in these patients were 3·3(1·4) pmol/l and 2·27(0·10) mmol/l respectively on POD 1, and 4·0(1.6) pmol/l and 2·32(0·08) mmol/l on POD 10. Two of the six patients in whom no well vascularized parathyroid gland could be demonstrated developed transient hypoparathyroidism. None of the 36 patients presented symptomatic hypocalcaemia, and none received treatment for hypoparathyroidism.Conclusion PTH levels on POD 1 were normal in all patients who had at least one well vascularized parathyroid gland demonstrated during surgery by ICG angiography, and none required treatment for hypoparathyroidism.

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“…Subsequently, ICG angiography has been used to identify sentinel lymph nodes (37), determine the extent of oncologic resections (38), and study hepatic function (39). Recent studies have also demonstrated its usefulness in evaluating the vascular blood flow of intestinal anastomoses (40) and tissue flap reconstructions (41).…”

Section: Fluorescent Techniques With Icg In Neck Surgerymentioning

confidence: 99%

A reappraisal of vascular anatomy of the parathyroid gland based on fluorescence techniques

Sadowski¹,

Fortuny²,

Triponez³

2017

Gland Surg.

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Indocyanine green plasma disappearance rate as dynamic liver function test in critically ill patients

Abstract: In conclusion, measuring ICG-PDR is a valuable method for dynamic assessment of liver function, and is found to be a valuable prognostic tool in predicting survival for septic patients, patients presenting with acute liver failure and critically ill patients.

Cited by 67 publications

References 27 publications

Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Parathyroid gland angiography with indocyanine green fluorescence to predict parathyroid function after thyroid surgery

A reappraisal of vascular anatomy of the parathyroid gland based on fluorescence techniques

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