2009
DOI: 10.1007/s00467-008-1114-5
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Indomethacin, ibuprofen and gentamicin administered during late stages of glomerulogenesis do not reduce glomerular number at 14 days of age in the neonatal rat

Abstract: Premature neonates are frequently administered indomethacin, ibuprofen and gentamicin during the period of active glomerulogenesis. These drugs are known to have nephrotoxic effects, but the morphological effect of these drugs is unknown. The purpose of this study was to determine whether administration of these drugs during the late stages of glomerulogenesis in the rat has an effect on glomerular endowment. Rat pups were given, intraperitoneally, indomethacin, ibuprofen or indomethacin and gentamicin for the… Show more

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Cited by 26 publications
(21 citation statements)
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References 44 publications
(48 reference statements)
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“…Therefore, it is possible that any adverse effect NSAID exposure has on the kidney may be short-lived and therefore would not significantly influence final nephron endowment. Indeed Kent et al (17), in a stereological assessment of nephron endowment following in vivo NSAID exposure, demonstrated in a neonatal rat model that total nephron endowment was not altered following extended postnatal exposure to NSAIDs. In that study, the NSAIDs were administered over a period equivalent to 24-to 30-wk gestation in humans (17), a much longer time period of exposure than in the current study.…”
Section: Discussionmentioning
confidence: 99%
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“…Therefore, it is possible that any adverse effect NSAID exposure has on the kidney may be short-lived and therefore would not significantly influence final nephron endowment. Indeed Kent et al (17), in a stereological assessment of nephron endowment following in vivo NSAID exposure, demonstrated in a neonatal rat model that total nephron endowment was not altered following extended postnatal exposure to NSAIDs. In that study, the NSAIDs were administered over a period equivalent to 24-to 30-wk gestation in humans (17), a much longer time period of exposure than in the current study.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed Kent et al (17), in a stereological assessment of nephron endowment following in vivo NSAID exposure, demonstrated in a neonatal rat model that total nephron endowment was not altered following extended postnatal exposure to NSAIDs. In that study, the NSAIDs were administered over a period equivalent to 24-to 30-wk gestation in humans (17), a much longer time period of exposure than in the current study. An examination of the baboon kidneys at a later postnatal time point, after the treatments and nephrogenesis have ceased, would be required to fully describe the long-term effects of NSAID exposure on renal development.…”
Section: Discussionmentioning
confidence: 99%
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“…These drugs inhibit the (renal) cyclooxygenase system, and a well known side effect of treatment in premature neonates is anuria or oliguria during the course of treatment, which occurs less often during treatment with ibuprofen (25). Because a normalfunctioning cyclooxygenase system is essential for nephrogenesis, it can be expected that these drugs not only influence short-term renal function, but also impair nephron formation (21,26,27). Indeed, harmful renal effects have been shown of acetylsalicyclic acid, another prostaglandin synthetase inhibitor (28).…”
Section: Nephrotoxic Drugsmentioning
confidence: 99%
“…Indomethacin is a tocolytic drug, which functions to reduce prostaglandin synthesis; it is thereby highly effective at prolonging pregnancy [104]. Of concern, however, in rodent studies in utero exposure to indomethacin has been reported to reduce nephron endowment and reduce glomerular filtration [105,106].…”
Section: Indomethacinmentioning
confidence: 99%