Induced Chromosomal Aberrations in Man

Genetic risks caused by occupational chemicals. Use of experimental methods and occupational risk group monitoring in the detection of environmental chemicals causing mutations, cancer and malformations.

“…The most clear-cut correlation is revealed in populations exposed to ionizing radiation, either occupationally or in other situations (12). A causal correlation between chromosomal aberrations in peripheral blood and a later increase in cancer incidence has been shown in several groups exposed to radiation, such as in patients receiving thorium dioxide for angiography (39) or patients in radiotherapy due to ankylosing spondylitis (18).…”

Chromosomal breakage in leukocytes of South American Indians

“…When needed to define the aberration more precisely, a formal karyotype was prepared. Each aberration was classified and recorded according to the definitions provided in a recent review of induced chromosomal aberrations (Bloom, 1972). For purposes of summarizing these extensive data, however, we have divided here the findings into five categories, designated A through E. The A cells were those with so-called one-hit aber rations, being largely single chromatid breaks but also including isochromatid breaks and free, acentric fragments.…”

A Raised Incidence of HL-A2 plus HL-A9 and other Anomalies of the HL-A Antigens of Patients with Leukaemia

“…What seems more probable is that the treatment received by these patients is responsible for the changes, especially as it is already well known that radiotherapy and certain drugs, including cytosine arabinoside used in leukaemia therapy, can cause chromosome aberrations [15]. The most likely alteration is the deletion of all or part of a chromosome, which would certainly explain why antigens and sometimes total antigenicity, are lost in many of the pa tients who have received radiotherapy.…”

“…A further possibility is that, though the disease itself may have no effect upon the antigenicity of the cells, the treatment these patients are receiving may result in alterations to the antigens, or to a partial or total loss in antigenicity. It is known that both radiotherapy and certain drugs including at least one, cytosine arabinoside, used in the treatment of leukaemia can cause chromosome aber rations [15] which may result in antigen changes.…”