Induction and transfer of resistance to poisoning by Amorimia pubiflora in sheep whith non-toxic dosis of the plant and ruminal content

Becker, Marciel; Carneiro, Faber Monteiro; Oliveira, Leonardo Pintar de; Silva, Mayara Inácio Vincenzi da; Riet-Correa, Franklin; Lee, Stephen Thomas; Pescador, Caroline Argenta; Nakazato, Luciano; Colodel, Edson Moleta

doi:10.1590/0103-8478cr20141484

Cited by 7 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was reported that feeding repeated low non-toxic doses of fluoroacetate containing plants to ruminants will confer resistance against fluoroacetate poisoning [ 150 ]. Furthermore, the resistance can be transferred to naïve animals through ruminal fluid transfer from experienced animals.…”

Section: Rumen Microbial Detoxification Of Plant Toxinsmentioning

confidence: 99%

“…Goats that were fed with increasing doses of fluoroacetate containing Amorimia septentrionalis in alternating periods, showed that the adapted goats possessed resistance against fluoroacetate poisoning while transfaunated goats, with adapted rumen fluid, showed clinical signs of poisoning much later compared to control goats [ 151 ]. Resistance against fluoroacetate poisoning was also observed in sheep fed with non-toxic doses of Amorimia pubiflora while transfaunated sheep, with adapted rumen fluid, showed initial clinical poisoning symptoms significantly later than the control group [ 150 ]. Although the above-mentioned studies did not report on any rumen bacteria isolations responsible for fluoroacetate degradation, it is predicted that these rumen bacteria would possess fluoroacetate dehalogenase activity capable of reductively breaking the carbon-fluorine bond in fluoroacetate [ 152 ].…”

Section: Rumen Microbial Detoxification Of Plant Toxinsmentioning

confidence: 99%

See 1 more Smart Citation

Toxin Degradation by Rumen Microorganisms: A Review

Loh

Ouwerkerk

Klieve

et al. 2020

Toxins

View full text Add to dashboard Cite

Animal feeds may contain exogenous compounds that can induce toxicity when ruminants ingest them. These toxins are secondary metabolites originating from various sources including plants, bacteria, algae and fungi. Animal feed toxins are responsible for various animal poisonings which negatively impact the livestock industry. Poisoning is more frequently reported in newly exposed, naïve ruminants while ‘experienced’ ruminants are observed to better tolerate toxin-contaminated feed. Ruminants can possess detoxification ability through rumen microorganisms with the rumen microbiome able to adapt to utilise toxic secondary metabolites. The ability of rumen microorganisms to metabolise these toxins has been used as a basis for the development of preventative probiotics to confer resistance against the poisoning to naïve ruminants. In this review, detoxification of various toxins, which include plant toxins, cyanobacteria toxins and plant-associated fungal mycotoxins, by rumen microorganisms is discussed. The review will include clinical studies of the animal poisoning caused by these toxins, the toxin mechanism of action, toxin degradation by rumen microorganisms, reported and hypothesised detoxification mechanisms and identified toxin metabolites with their toxicity compared to their parent toxin. This review highlights the commercial potential of rumen inoculum derived probiotics as viable means of improving ruminant health and production.

show abstract

Section: Rumen Microbial Detoxification Of Plant Toxinsmentioning

confidence: 99%

Section: Rumen Microbial Detoxification Of Plant Toxinsmentioning

confidence: 99%

Toxin Degradation by Rumen Microorganisms: A Review

Loh

Ouwerkerk

Klieve

et al. 2020

Toxins

View full text Add to dashboard Cite

show abstract

“…In Brazil, there are widespread reports that animals coming from areas with occurrence of MFA-containing plants are more resistant to poisoning by plants containing this compound than animals grazing on pastures of free of these plants (Silva et al 2008). It is believed that this occurs because of the time of evolutionary exposure to these pastures, by dietary preference, levels of dietary specialization, and habitat preference (Twigg & King 2000), as well as because these animals possibly have bacteria in their rumen that are capable of degrading the MFA through production of the fluoroacetate dehalogenase enzyme (Becker et al 2016).…”

Section: Administration Of Non-toxic Doses Of Mfa or Mfa-containing Plantsmentioning

confidence: 99%

Techniques for prevention and control of poisoning by sodium monofluoroacetate (MFA)-containing plants in ruminants

2019

Self Cite

View full text Add to dashboard Cite

Monofluoroacetate (MFA)-containing plants cause sudden death associated with exercise in ruminants, and are responsible for significant losses in Brazilian livestock, estimated at 500,000 bovine deaths annually. Most of the times, the control and treatment of this type of poisoning are not efficient, because disease evolution is superacute, usually causing the death of the animal. Due to the difficulty in controlling this intoxication, several studies have suggested alternatives to prevent it, mainly by making animals resistant to the MFA present in these plants or by avoiding their consumption. This literature review addresses the techniques used experimentally to control the poisoning of ruminants by plants containing MFA. The first studies carried out in Brazil demonstrated that goats and sheep that continuously receive non-toxic doses of plant containing MFA show greater resistance to poisoning than untreated animals, and that this resistance can be transmitted by ruminal fluid transfaunation, suggesting that poisoning occurs due to the presence of bacteria that hydrolyze MFA in the rumen. Based on this hypothesis, several MFA-hydrolyzing bacteria were isolated (Enterococcus faecalis, Bacillus sp., Paenibacillus sp., Burkholderia sp., Cupriavidus sp., Staphylococcus sp., Ancylobacter sp., Ralstonia sp., Stenotrophomonas sp., Pigmentiphaga kullae, and Ancylobacter dichloromethanicus). When some of these bacteria were administered intraruminally, they provided the animal with a different level of protection against poisoning. However, it was observed that protection is gradually lost when the bacterium administration is interrupted. Consequently, to obtain more efficient protection, these bacteria should be administered continuously, probably in the form of probiotics. In another assay, MFA was administered to sheep at non-toxic doses to test the hypothesis that this substance could induce the multiplication of bacteria that hydrolyze it in the rumen. There was no increase in resistance to poisoning after administration of MFA; however, no signs of poisoning were observed when animals received trifluoroacetate and no clinical signs were verified when they were challenged with toxic doses of MFA; in contrast, all control animals presented clinical signs. These results suggest that trifluoroacetate induces the proliferation of MFA-degrading bacteria, and can be used in intoxication prophylaxis. The conditioned food aversion technique, using lithium chloride, has been successfully used experimentally to prevent ruminants from ingesting plants that contain MFA. Another alternative tested was the spraying of Amorimia septentrionalis with the endophytic bacterium Herbaspirillum seropedicae, which degrades MFA, resulting in decreased concentration of this compound in the plants. In conclusion, several experimental techniques have been proved efficient in the control and prophylaxis of MFA-containing plant poisoning; however, none of these techniques are available commercially. Further experiments, mainly in the field, should be carried out to adapt some of these techniques to the conditions of extensive breeding in the numerous areas where MFA-containing plants occur.

show abstract

“…Também foi comprovado que a administração de doses não tóxicas repetidas de folhas de A. septentrionalis induz resistência à intoxicação por essa planta e que essa resistência pode ser transmitida de animais resistentes para animais susceptíveis pela transfaunação de líquido ruminal (Duarte 2012). A mesma técnica foi utilizada com sucesso contra a intoxicação por A. pubiflora (Becker et al 2016).…”

Section: Diagnóstico Tratamento E Medidas Preventivas Ou De Controleunclassified

Plantas cardiotóxicas para ruminantes no Brasil

et al. 2018

Self Cite

View full text Add to dashboard Cite

RESUMO: Esta revisão atualiza informações sobre plantas cardiotóxicas que afetam os ruminantes no Brasil. Atualmente, sabe-se que existem pelo menos 131 plantas tóxicas pertencentes a 79 gêneros. Vinte e cinco espécies afetam o funcionamento do coração. As plantas que contêm monofluoroacetato de sódio (Palicourea spp., Psychotria hoffmannseggiana, Amorimia spp., Niedenzuella spp., Tanaecium bilabiatum e Fridericia elegans) causam numerosos surtos de intoxicação, principalmente em bovinos, mas búfalos, ovinos e caprinos são ocasionalmente afetados. A intoxicação por Palicourea marcgravii continua a ser a mais importante devido à ampla distribuição desta planta no Brasil. Novas espécies do gênero Palicourea contendo monofluoracetato de sódio, como Palicourea amapaensis, Palicourea longiflora, Palicourea barraensis, Palicourea macarthurorum, Palicourea nigricans, Palicourea vacillans e Palicourea aff. juruana foram descritas na região amazônica. Na região nordeste, a planta tóxica mais importante para bovinos é Amorimia septentrionalis. No Centro-Oeste, surtos de intoxicação por Niedenzuella stannea foram relatados em bovinos na região do Araguaia e a doença precisa ser melhor investigada quanto à sua ocorrência e importância. Tetrapterys multiglandulosa e Tetrapterys acutifolia, duas plantas que causam fibrose cardíaca, também contêm monofluoracetato de sódio e foram reclassificadas para o gênero Niedenzuella. Essas duas espécies e Ateleia glazioveana, outra planta que causa fibrose cardíaca, continuam sendo importantes no Sul e Sudeste do Brasil. Outras espécies menos importantes e que ocasionamente provocam surtos acidentais de intoxicação são as plantas que contém glicosídeos cardiotóxicos, tais como Nerium oleander e Kalanchoe blossfeldiana. Recentemente, várias metodologias experimentais foram empregadas para evitar intoxicações por plantas que contêm monofluoroacetato de sódio. Estas metodologias incluem a indução de aversão condicionada utilizando cloreto de lítio, a utilização de doses repetidas não tóxicas de folhas para induzir resistência, o uso de acetamida para prevenir as intoxicações e a inoculação intraruminal de bactérias degradantes de monofluoroacetato de sódio.

show abstract

Induction and transfer of resistance to poisoning by Amorimia pubiflora in sheep whith non-toxic dosis of the plant and ruminal content

Cited by 7 publications

References 9 publications

Toxin Degradation by Rumen Microorganisms: A Review

Toxin Degradation by Rumen Microorganisms: A Review

Techniques for prevention and control of poisoning by sodium monofluoroacetate (MFA)-containing plants in ruminants

Plantas cardiotóxicas para ruminantes no Brasil

Contact Info

Product

Resources

About