Induction of activation-induced cytidine deaminase by a not-directly mutagenic carcinogen: a novel potential molecular mechanism

Tatemichi, Masayuki; Hata, Hirofumi; Nakadate, Toshio

doi:10.1007/s12199-014-0382-x

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…These genotoxic carcinogens are capable of altering the genetic makeup of target cells (19) causing multiple mutations in the critical genes in the human body which may lead to accumulation of irreversible DNA damage and ultimately cancer development (20). Apart from its genotoxic role, trace elements have also been reported as non-genotoxic carcinogens (21) that act via secondary mechanisms such as tumor promoters (22), endocrinemodifiers (23), receptor mediators (24), immunosuppressants (25), or inducers of tissue-specific toxicity and inflammatory responses (26). These non-genotoxic mechanisms vary diversely and are complex, hence they remain challenging to comprehend in terms of their full carcinogenic potential.…”

Section: Introductionmentioning

confidence: 99%

Tissue and Serum Trace Elements Concentration among Colorectal Patients: A Systematic Review of Case-Control Studies

Nawi¹,

Chin²,

Shah³

et al. 2019

ijph

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Background: Trace elements play a pivotal role in Colorectal Cancer (CRC) inhibition and development process. This systematic review provides the basic comparison of case-control studies focusing on concentration of trace elements between those with CRC and controls Methods: The systematic review searched through two databases of Medline and Cochrane up to 24th June 2017. The search strategy focused on Population, Intervention, Comparison, and Outcomes (PICO). We searched the role of trace elements in cancer and focusing on case-control studies in CRC to obtain an insight into the differences in trace element concentrations between those with and without cancer. Results: The serum concentrations of Ca, Cu, Mg, Mn, Se, Si, and Zn were lower in CRC patients but for Co and S the levels were higher in CRC patients. The concentrations of Cd, Cr, Cu, Mg, Mn, Pb, and Zn were increased in patients with metastasis, but not in Se. As for colon tissue specimens, inconsistent levels were reported between studies, notably in Cu, Se, and Zn. No changes were reported for B and Ca levels. Most of the trace elements in the tissue specimens showed higher concentrations of Cr, Fe, K, Mg, P, Rb, S, and Si compared to Br. Conclusion: With the growing interest to understand the link between trace elements in carcinogenesis and the possible interactions, multi assessment analysis of a larger cohort of samples is necessary.

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Section: Introductionmentioning

confidence: 99%

Tissue and Serum Trace Elements Concentration among Colorectal Patients: A Systematic Review of Case-Control Studies

Nawi¹,

Chin²,

Shah³

et al. 2019

ijph

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“…Significant differences in the levels of trace elements have been observed in many diseases such as breast cancer [2], acute leukemia [3], diabetes [4] and Parkinson’s disease [5]. It has been postulated that the pathological events associated to trace elements were driven by activation in pathways closely linked to genotoxicity [6], endocrine modifications [7], receptor mediation [8], immunosuppression [9], tumour promotion [10], tissue-specific toxicity and inflammatory responses [11].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous analysis of 25 trace elements in micro volume of human serum by inductively coupled plasma mass spectrometry (ICP-MS)

Nawi

Chin

Jamal

2020

Practical Laboratory Medicine

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IntroductionIn recent years, trace elements have gained importance as biomarkers in many chronic diseases. Unfortunately, the requirement for sample volume increases with the extent of investigation either for diagnosis or elucidating the mechanism of the disease. Here, we describe the method development and validation for simultaneous determination of 25 trace elements (lithium [Li], beryllium [Be], magnesium [Mg], aluminium [Al], vanadium [V], chromium [Cr], manganese [Mn], iron [Fe], cobalt [Co], nickel [Ni], copper [Cu], zinc [Zn], gallium [Ga], arsenic [As], selenium [Se], rubidium [Rb], strontium [Sr], silver [Ag], cadmium [Cd], caesium [Cs], barium [Ba], mercury [Hg], thallium [Tl], lead [Pb], uranium [U]) using only 20 μL of human serum.MethodsSerum samples were digested with nitric acid and hydrochloric acid (ratio 1:1, v/v) and analysed by inductively coupled plasma–mass spectrometry (ICP-MS). Seronorm®, a human-derived serum control material was used as quality control samples.ResultsThe coefficient of variations for both intra- and inter-day precisions were consistently <15% for all elements. The validated method was later tested on 30 human serum samples to evaluate its applicability.ConclusionWe have successfully developed and validated a precise and accurate analytical method for determining 25 trace elements requiring very low volume of human serum.

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Induction of activation-induced cytidine deaminase by a not-directly mutagenic carcinogen: a novel potential molecular mechanism

Abstract: A not-directly mutagenic carcinogen, cadmium, has the potential to induce the AID gene, suggesting that this might represent a novel molecular mechanism of carcinogenesis of cadmium.

Cited by 2 publications

References 21 publications

Tissue and Serum Trace Elements Concentration among Colorectal Patients: A Systematic Review of Case-Control Studies

Tissue and Serum Trace Elements Concentration among Colorectal Patients: A Systematic Review of Case-Control Studies

Simultaneous analysis of 25 trace elements in micro volume of human serum by inductively coupled plasma mass spectrometry (ICP-MS)

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