2010
DOI: 10.1016/j.fct.2010.06.006
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Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract

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Cited by 63 publications
(26 citation statements)
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“…These findings indicate that the citrus fruit extract exhibited antiproliferative activity in selected human cancer cell lines. As all extracts showed the antiproliferative activity, this result was in agreement with a recent investigation into in vitro antioxidant activity and prevention of cancer (Lim et al, 2009;Kim et al, 2010; Cho compound content of carotenes, phenolics, waxes, phytosterols, and sesquiterpene, and monoterpene volatiles (Ranalli et al, 2004). The presence of polymethoxy flavone, unsaturated fatty acids, phytosterols, and several terpenoids in citrus extracts are particularly important because they promote anticancer effects, which enhance the value of the product.…”
Section: Gc-ms Analysis Chromatographic Analysis Was Carried Out Usinsupporting
confidence: 77%
See 1 more Smart Citation
“…These findings indicate that the citrus fruit extract exhibited antiproliferative activity in selected human cancer cell lines. As all extracts showed the antiproliferative activity, this result was in agreement with a recent investigation into in vitro antioxidant activity and prevention of cancer (Lim et al, 2009;Kim et al, 2010; Cho compound content of carotenes, phenolics, waxes, phytosterols, and sesquiterpene, and monoterpene volatiles (Ranalli et al, 2004). The presence of polymethoxy flavone, unsaturated fatty acids, phytosterols, and several terpenoids in citrus extracts are particularly important because they promote anticancer effects, which enhance the value of the product.…”
Section: Gc-ms Analysis Chromatographic Analysis Was Carried Out Usinsupporting
confidence: 77%
“…Our group has mainly focused on identifying anticancer and antioxidant activities and characterizing citrus phytochemical profiles (Lim et al, 2006;Kim et al, 2008;Yang et al, 2008). Recent investigations from our laboratory provided evidence for the health-promoting properties of citrus in cell culture studies, such as antioxidant activity and prevention of cancer (Lim et al, 2009;Kim et al, 2010;Cho et al, 2009;Moon et al, 2009).…”
Section: Methodsmentioning
confidence: 99%
“…Tangeretin also inhibited the P-glycoprotein function and significantly influenced the cell cycle, whereas they did not induce apoptosis of MOLT4 Daunorubicin-Resistant T Lymphoblastoid Leukemia Cells (Ishii et al 2010). Chloroform fraction of Citrus grandis leaf extract that contains tangeretin induced apoptosis showed by decreasing of the protein levels of the precursors of caspase-9, -8, -3, and -7 and cleaving of PARP (Kim et al 2010). Thus tangeretin probably also induced apoptosis of MCF-7 and T47D cells.…”
Section: Discussionmentioning
confidence: 87%
“…The cells were treated with 0, 30, and 100 µM resveratrol for 48 h. Immunoblotting was performed using a slightly modified method described elsewhere [Choi et al, 2010;Kim et al, 2010]. The anticleaved caspases-3, -7 or -9 antibody (1:1000 dilution, Cell Signaling Technology, Inc., Boston, MA) was used as the primary antibody.…”
Section: Methodsmentioning
confidence: 99%