Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin

Chan, F.H.Y.; Choi, H.L.; Chen, Z.Y.; Chan, Peter S.; Huang, Yü

doi:10.1016/s0304-3835(00)00591-7

Cited by 217 publications

(121 citation statements)

References 23 publications

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“…However, the actions of flavonoids are complex and often seemingly antagonistic or paradoxical. For example, while flavonoids are described as antioxidant agents protecting against oxidative insults to cells and apoptosis [11,13,88], others have found flavonoids to be pro-oxidants and -apoptotic [33,212,221]. Thus, it becomes clear that the effects of flavonoids depend on different factors such as the specific compound used, the cell type, concentrations, experimental design, and the general context in which flavonoids are used.…”

Section: Biological and Cellular Propertiesmentioning

confidence: 99%

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter

Boyd

Spencer

et al. 2002

Neurobiology of Aging

310

178

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Oxidative and nitrosative stress is increasingly associated with the pathology of neurodegeneration and aging. The molecular mechanisms underlying oxidative/nitrosative stress-induced neuronal damage are emerging and appear to involve a mode of death in which mitogen-activated protein kinase (MAPK) signaling pathways are strongly implicated. Thus, attention is turning towards the modulation of intracellular signaling as a therapeutic approach against neurodegeneration. Both endogenous and dietary agents have been suggested as potent modulators of intracellular signal transduction, e.g. nitric oxide and flavonoids, respectively. This review addresses recent findings on the biological effects of flavonoids and nitric oxide in neurodegeneration and aims to elucidate the rationale for their prospective use as modulators of cellular signal transduction. © 2002 Elsevier Science Inc. All rights reserved.Keywords: Apoptosis; Oxidative stress; Neuron; Flavonoids; MAP kinase; JNK; ERK; Epicatechin; Nitric oxide; Mitochondria; Redox status; Polyphenols Abbreviations: AKT, serine/threonine kinase (also known as protein kinase B); AP-1, activator protein-1; Apaf-1, apoptosis protease activating factor-1; ASK1, apoptosis signal-regulating kinase-1; Bad, Bcl-2/BclX Lassociated death promoting protein; Bax, pro-apoptotic protein of the Bcl-2 family; Bcl-2, B-cell lymphoma 2: protein with anti-apoptotic properties; BclX L , long form of Bclx: anti-apoptotic protein of the Bcl-2 family; Caspase, cysteinyl aspartic acid-protease; c-Jun, mammalian equivalent of Jun: part of the AP-1 transcription complex; CREB, cAMP response element binding protein; DIABLO/smac, mitochondria-related pro-apoptotic protein: inhibits XIAP; ERK1/2, extracellular signal-related kinase; Fas, CD95: member of the TNF receptor family; GSHST, glutathione Stransferase; JNK, c-Jun amino-terminal kinase; MAPK, mitogen-activated protein kinase; MAPKK, MAPK kinase; MAPKKK, MAPKK kinase; MEK1/2, ERK1/2-specific MAPKK; MKK4/7, JNK-specific MAPKK; MSK1, mitogen-and stress-activated kinase-1; NF-B, nuclear factor of immunoglobulin k locus in B-cells; ONOO − , peroxynitrite anion; p53, pro-apoptotic tumor suppressor gene product; PI3-kinase, phosphoinositol 3-kinase; Ras, small G-protein; RNS, reactive nitrogen species; ROS, reactive oxygen species; RSK, pp90 ribosomal S6 kinase; SAPK, stressactivated protein kinase; XIAP, X-linked inhibitor of apoptosis: inhibits the activation of caspase-9

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Section: Biological and Cellular Propertiesmentioning

confidence: 99%

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter

Boyd

Spencer

et al. 2002

Neurobiology of Aging

310

178

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“…The inhibitory effects of baicalein and baicalin on expansion of human viruses (Bayer et al, 1992;Wu et al, 1995), and a protective effect of baicalin on renal cell injury (Yokozawa et al, 1999) have been reported. It was also reported that baicalein, baicalin and wogonin showed suppression activity against the production of nitric oxide/prostaglandin E 2 (Chen et al, 2001;Chi et al, 2001) and proliferation of cancer cells (Chan et al, 2000;Chen et al, 2002;Matsuzaki et al, 1996;Okita et al, 1993;Yano et al, 1994).…”

Section: Introductionmentioning

confidence: 97%

High-yield production of scutellaria radix flavonoids (baicalein, baicalin and wogonin) by liquid-culture of Scutellaria baicalensis root-derived cells

Ohtsuki

Himeji

Fukazawa

et al. 2009

Braz. arch. biol. technol.

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“…Baicalin is known to have many biological functions, including antimicrobial activities (Gao et al, 1999), antitumor effects (Chan et al, 2000;Wang et al, 2008;Li-Weber, 2009), anti-inflammatory (Lin et al, 2008), and antiviral activities (Li et al, 2000;Wang et al, 2004). However, the functional correlation between appetite inhibition and baicalin is currently unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Baicalin is known to have multiple biological functions, including antibacterial (Huang et al, 2009), anti-inflammatory (Lin et al, 2008), antiviral (Li et al, 2000; 2004), and antitumor effects (Chan et al, 2000;Wang et al, 2008;Li-Weber, 2009). However, the relationships between food intake and the anorexigenic neuropeptides have not been reported.…”

Section: Introductionmentioning

confidence: 99%

The Inhibitory Effect of Baicalin on the Short-Term Food Intake in C57BL/6J Mice

Kim¹,

Son²,

Myoung³

et al. 2010

Biomolecules and Therapeutics

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-Appetite is inhibited by the anorexigenic neuropeptides POMC (proopiomelanocortin) and CART (cocaine-amphetamine-regulated transcript) in the hypothalamus. The present study was performed to examine the inhibitory effects of baicalin against food intake and the upregulation of POMC/CART. Short-term food intake (48 h) was significantly inhibited by treatment with baicalin (10 mg/kg, p＜0.05) in C57BL/6 mice. Immunohistochemical analysis showed that baicalin upregulated POMC and CART levels in the arcuate nucleus of the hypothalamus. These effects were also examined using an in vitro system. pPOMC-Luc or pCART-Luc plasmids were transformed into mouse N29-2 neuronal and human SH-SY5Y cells, and the activities of baicalin were examined in these cells. Baicalin increased POMC and CART promoter-driven luciferase activity in a dose-dependent manner without cytotoxic effects. These results suggest that baicalin downregulates short-term food intake while upregulating POMC and CART expression.

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Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin

Cited by 217 publications

References 23 publications

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

High-yield production of scutellaria radix flavonoids (baicalein, baicalin and wogonin) by liquid-culture of Scutellaria baicalensis root-derived cells

The Inhibitory Effect of Baicalin on the Short-Term Food Intake in C57BL/6J Mice

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