Induction of High Endothelial Venule‐like Vessels Expressing GlcNAc6ST‐1‐mediated L‐selectin Ligand Carbohydrate and Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM‐1) in a Mouse Model of “<i>Candidatus</i> Helicobacter heilmannii”‐induced Gastritis and Gastric Mucosa‐associated Lymphoid Tissue (MALT) Lymphoma

Suzuki, Akira; Kobayashi, Motohiro; Matsuda, Kazuyuki; Matsumoto, Takeshi; Kawakubo, Masatomo; Kumazawa, Shigeyuki; Koide, Naoki; Miyagawa, Shinichi; Ota, Hiroyoshi

doi:10.1111/j.1523-5378.2010.00801.x

Cited by 18 publications

(10 citation statements)

References 36 publications

(63 reference statements)

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“…H. helmanii , found in both human and mice, also lead to MALT lymphoma that is preceded by inflammation and high endothelial venule-like vesicles, which are associated with lymphocyte recruitment and present in other chronic inflammatory conditions such as rheumatoid arthritis, and colitis (32). The animal models of H helmanii -induced lymphoma, however, seem to have varying results and may also involve host and bacterial factors (33).…”

Section: Microbiota and Lymphoma In Animal Modelsmentioning

confidence: 99%

Intestinal Microbiome and Lymphoma Development

Yamamoto

Schiestl²

2014

The Cancer Journal

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The intestinal microbiota and gut immune system must communicate to maintain a balance between tolerance and activation. Our immune system protects us from pathogenic microbes at the same time that our bodies are host to trillions of microbes, symbionts, mutualists, and some that are essential to human health. Since there is such a close interaction between the immune system and the intestinal microbiota, it is not surprising that some lymphomas such as mucosal-associated lymphoid tissue (MALT) lymphoma have been shown to be caused by the presence of certain bacteria. Animal models have played an important role in elucidating the causation and establishing the mechanism of bacteria-induced MALT lymphoma. In this review, we discuss different ways that animal models have been applied to investigate links between the gut microbiota and lymphoma and have helped to reveal the mechanisms of microbiota-induced lymphoma. While there is a paucity of published studies demonstrating the interplay between the microbiota and lymphoma development, we believe that the connection is real and that it can be exploited in the future to enhance our understanding of causation and to improve the prognosis and treatment of lymphoma.

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Section: Microbiota and Lymphoma In Animal Modelsmentioning

confidence: 99%

Intestinal Microbiome and Lymphoma Development

Yamamoto

Schiestl²

2014

The Cancer Journal

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“…Suzuki et al. [36] examined the expression of vascular addressins and related transcripts in H. suis ‐infected BALB/c mice. The infected mice showed chronic gastritis that increased in severity during infection.…”

Section: Pathogenesis Of and Immune Response To Non‐helicobacter Pylomentioning

confidence: 99%

The Other Helicobacters

et al. 2011

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The last year has seen an interesting and important collection of evidence presented in the field of the “other” than Helicobacter pylori Helicobacters. Associations with adult ulcerative colitis and biliary/hepatic disease have been described. New insights into the immune response and subsequent pathogenesis associated with infection have also been published. Genomic advances include description of new and unique species and the complete genome description for both Helicobacter felis and Helicobacter suis. Molecular studies have also elucidated the mechanism of action of some functional components of these organisms.

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“…develop MALT lymphoma more frequently than those with H. pylori [56] . Although in the previous studies there was not a clear identification of the bacteria at a species level, in experimentally infected animal models the administration of H. heilmannii s.s.-positive gastric biopsy homogenates to BALB/c and to C57BL/6 mice induced gastric MALT lymphoma [57][58][59] . Furthermore, infection with pure bacterial isolates of H. felis [60][61][62] and of H. suis [63] were shown to induce gastric MALT lymphoma-like lesions in the BALB/c and in the Mongolian gerbil models, respectively.…”

Section: H Heilmannii Sl-associated Diseases In Humansmentioning

confidence: 99%

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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Helicobacter heilmannii sensu lato (H. heilmannii s.l.) is a group of gastric non-Helicobacter pylori Helicobacter species that are morphologically indistinguishable from each other. H. heilmannii s.l. infect the stomach of several animals and may have zoonotic potential. Although the prevalence of these infections in humans is low, they are associated with gastric pathology, including mucosa-associated lymphoid tissue lymphoma, making them a significant health issue. Here, the taxonomy, epidemiology, microbiology, diagnosis, and treatment of these infections will be reviewed. The gastric pathology associated with H. heilmannii s.l. infections in humans will also be addressed. Finally, the features of the complete bacterial genomes available and studies on species-specific pathogenesis will be reviewed. The understanding of the mechanisms that underlie gastric disease development mediated by the different bacterial species that constitute H. heilmannii s.l. is essential for developing strategies for prevention and treatment of these infections. Core tip: Helicobacter heilmannii sensu lato is a group of non-Helicobacter pylori Helicobacter species that infect the stomach of animals and humans. In the human stomach, these infections are associated with several pathologies, but it is currently unknown whether certain species are more often associated with a certain disease outcome than others. The access to bacterial genomes together with the availability of increasing numbers of in vitro isolates will allow significant advances in the understanding of species-specific bacteria-host interactions in disease pathogenesis and will be essential for future development of strategies to prevent and treat these infections.

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Abstract: HEV-like vessels expressing GlcNAc6ST-1-mediated L-selectin ligand carbohydrate and MAdCAM-1 may play a crucial role in the pathogenesis of "Candidatus Helicobacter heilmannii"-induced chronic gastritis and MALT lymphoma.

Cited by 18 publications

References 36 publications

Intestinal Microbiome and Lymphoma Development

Intestinal Microbiome and Lymphoma Development

The Other Helicobacters

Helicobacter heilmannii sensu lato: An overview of the infection in humans

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